scholarly journals Alterations in Marginal Zone Macrophages and Marginal Zone B Cells in Old Mice

2011 ◽  
Vol 186 (6) ◽  
pp. 3441-3451 ◽  
Author(s):  
Shirin Z. Birjandi ◽  
Jill A. Ippolito ◽  
Anand K. Ramadorai ◽  
Pamela L. Witte
Keyword(s):  
B Cells ◽  
Marginal Zone ◽  
Marginal Zone B Cells ◽  
Old Mice ◽  
Marginal Zone Macrophages

Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae

2008 ◽  
Vol 45 (10) ◽  
pp. 2881-2887 ◽  
Author(s):  
Estella A. Koppel ◽  
Manja Litjens ◽  
Venice C. van den Berg ◽  
Yvette van Kooyk ◽  
Teunis B.H. Geijtenbeek
Keyword(s):  
Streptococcus Pneumoniae ◽  
B Cells ◽  
Marginal Zone ◽  
Marginal Zone B Cells ◽  
Marginal Zone Macrophages

scholarly journals Marginal Zone B Cells Regulate Antigen Capture by Marginal Zone Macrophages

2011 ◽  
Vol 186 (4) ◽  
pp. 2172-2181 ◽  
Author(s):  
Yuying You ◽  
Riley C. Myers ◽  
Larry Freeberg ◽  
Jeremy Foote ◽  
John F. Kearney ◽  
...  
Keyword(s):  
B Cells ◽  
Marginal Zone ◽  
Marginal Zone B Cells ◽  
Antigen Capture ◽  
Marginal Zone Macrophages

Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells

2009 ◽  
Vol 417 (3) ◽  
pp. 673-683 ◽  
Author(s):  
Munetoyo Toda ◽  
Risa Hisano ◽  
Hajime Yurugi ◽  
Kaoru Akita ◽  
Kouji Maruyama ◽  
...  
Keyword(s):  
Sialic Acid ◽  
B Cells ◽  
B Cell ◽  
Marginal Zone ◽  
Cell Signalling ◽  
Negative Regulator ◽  
Mammary Adenocarcinoma ◽  
Marginal Zone B Cells ◽  
Tumour Bearing

CD22 [Siglec-2 (sialic acid-binding, immunoglobulin-like lectin-2)], a negative regulator of B-cell signalling, binds to α2,6- sialic acid-linked glycoconjugates, including a sialyl-Tn antigen that is one of the typical tumour-associated carbohydrate antigens expressed on various mucins. Many epithelial tumours secrete mucins into tissues and/or the bloodstream. Mouse mammary adenocarcinoma cells, TA3-Ha, produce a mucin named epiglycanin, but a subline of them, TA3-St, does not. Epiglycanin binds to CD22 and inhibits B-cell signalling in vitro. The in vivo effect of mucins in the tumour-bearing state was investigated using these cell lines. It should be noted that splenic MZ (marginal zone) B-cells were dramatically reduced in the mice bearing TA3-Ha cells but not in those bearing TA3-St cells, this being consistent with the finding that the thymus-independent response was reduced in these mice. When the mucins were administered to normal mice, a portion of them was detected in the splenic MZ associated with the MZ B-cells. Furthermore, administration of mucins to normal mice clearly reduced the splenic MZ B-cells, similar to tumour-bearing mice. These results indicate that mucins in the bloodstream interacted with CD22, which led to impairment of the splenic MZ B-cells in the tumour-bearing state.

scholarly journals Marginal zone B cells: From housekeeping function to autoimmunity?

2021 ◽  
Vol 119 ◽  
pp. 102627
Author(s):  
Anna-Karin E. Palm ◽  
Sandra Kleinau
Keyword(s):  
B Cells ◽  
Marginal Zone ◽  
Marginal Zone B Cells

scholarly journals Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Maria Cristina de Vera Mudry ◽  
Franziska Regenass-Lechner ◽  
Laurence Ozmen ◽  
Bernd Altmann ◽  
Matthias Festag ◽  
...  
Keyword(s):  
Immune Response ◽  
B Cells ◽  
B Cell ◽  
Marginal Zone ◽  
Nuclear Translocation ◽  
Recovery Period ◽  
Functional Characterization ◽  
Notch Receptor ◽  
Marginal Zone B Cells ◽  
Cell Fate Decisions

Theγ-secretase complex is a promising target in Alzheimer’s disease because of its role in the amyloidogenic processing ofβ-amyloid precursor protein. This enzyme also catalyzes the cleavage of Notch receptor, resulting in the nuclear translocation of intracellular Notch where it modulates gene transcription. Notch signaling is essential in cell fate decisions during embryogenesis, neuronal differentiation, hematopoiesis, and development of T and B cells, including splenic marginal zone (MZ) B cells. This B cell compartment participates in the early phases of the immune response to blood-borne bacteria and viruses. Chronic treatment with the oralγ-secretase inhibitor RO4929097 resulted in dose-dependent decreased cellularity (atrophy) of the MZ of rats and mice. Significant decreases in relative MZ B-cell numbers of RO4929097-treated animals were confirmed by flow cytometry. Numbers of MZ B cells reverted to normal after a sufficient RO4929097-free recovery period. Functional characterization of the immune response in relation to RO4929097-related MZ B cell decrease was assessed in mice vaccinated with inactivated vesicular stomatitis virus (VSV). Compared with the immunosuppressant cyclosporin A, RO4929097 caused only mild and reversible delayed early neutralizing IgM and IgG responses to VSV. Thus, the functional consequence of MZ B cell decrease on host defense is comparatively mild.

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