CLINICAL-MORPHOLOGICAL CLASSIFICATION OF ACUTE THROMBOSIS OF THE EXTERNAL HEMORRHOID NODE IN RELATION TO A DIFFERENTIATED APPROACH IN ITS TREATMENT

Acute thrombosis of the external hemorrhoid node is one of the common manifestations of hemorrhoids and a frequent reason for seeking specialized medical care. Despite existing prospective studies proving the effectiveness of operative treatment, there is no clear position in determining the indications, timing and methods of surgery, nor the combination of the latter with conservative therapy.The article formulated and described the original clinical-morphological classification of acute thrombosis of the external hemorrhoid node based on the data of its ultrasound examination (ultrasound). Effectiveness of various methods of treating acute thrombobosis of external hemorrhoid node, carried out on the basis of proposed classification, is evaluated.Purpose of the study. Improving treatment outcomes for patients with acute thrombosis of the external hemorrhoid node.Results. Ultrasound types of thrombosis of external hemorrhoidal node are revealed:– mononuclear (in ultrasound, it is a single thrombus or a dense, intimately soldered group of thrombotic masses of an an- or isoechogenic structure with untested swelling of the skin and subcutaneous fat (PWD), from 10 mm or more in size);– polynuclear (clusters of thrombotic masses of an- or isoechogenic structure up to 10 mm in size, located at a short distance from each other, with moderate swelling of the skin and subcutaneous fat);– edema (during sonography, multiple small, up to 2–3 mm, anechogenic thrombotic masses are visualized against the background of pronounced edema of subcutaneous fat fiber and skin).Effectiveness of various methods of treating patients with acute thrombosis of external hemorrhoid node in groups formed on the basis of proposed classification is evaluated. It has been found that in patients with edematous sonographic type of thrombosis, it is more advisable to apply only conservative therapy or carry out surgical treatment after completion of taking diosmin-containing preparations. Such tactics reduced the duration of treatment and reduced pain syndrome. In patients with a mononuclear type of thrombosis of the external hemorrhoidal node, a similar result was noted during surgery and the beginning of conservative therapy on the day of circulation.Conclusion. Application of ultrasound diagnostics allows establishing the type of hemorrhoid node thrombosis and using the obtained data when choosing treatment tactics. A differentiated approach to treating this category of patients, based on the proposed classification, allows improving the treatment results of patients with acute thrombosis of the external hemorrhoid node.

The first amino acid bound manganese–calcium clusters: a {[MnIII3Ca]2} methylalanine complex, and a [MnIII6Ca] trigonal prism

The use of methylalanine in manganese/calcium chemistry has led to the synthesis and characterization of the first manganese/calcium amino acid containing polynuclear clusters.

Constructing [CoII6] hexagon-centered heterometallic {Ln6Co6} (Ln = Y, Eu and Dy) clusters with a calix[8]arene ligand

Three isostructural 3d–4f polynuclear clusters {(LnIII6CoII6)(C8A)3} (Ln = Y, Eu, Dy; C8A = p-tert-butylcalix[8]arene) feature some tripod-like entities in which three Ln2-C8A SBUs bolster a [Co6] hexagon.

Various Structural Types of Cyanide-Bridged FeIII–MnIII Bimetallic Coordination Polymers (CPs) and Polynuclear Clusters Based-on A New mer-Tricyanoiron(III)Building Block: Synthesis, Crystal Structures, and Magnetic Properties

Four cyanide-bridged FeIII–MnIII complexes {[Fe(qxcq)(CN)3][Mn(L1)(H2O)]}[Mn(L1)(H2O)(CH3OH)](ClO4)·1.5MeOH·0.5H2O (L1 = N,N′-bis(3-methoxy-5-bromosalicylideneiminate) (2), {[Fe(qxcq)(CN)3][Mn(L2)]}2·0.5H2O (L2 = N,N′-ethylene-bis(3-ethoxysalicylideneiminate)) (3), [Fe(qxcq)(CN)3][Mn(L3)] (L3 = bis(acetylacetonato)ethylenediimine) (4), [Fe(qxcq)(CN)3][Mn(L4)]·1.5MeOH·0.5CH3CN·0.25H2O (L4 = N,N′-(1,1,2,2-tetramethylethylene)bis(salicylideneiminate)) (5), were prepared by assembling a new structurally characterized mer-tricyanoiron(III) molecular precursor (Ph4P)[Fe(qxcq)(CN)3]·0.5H2O (qxcq− = 8-(2-quinoxaline-2-carboxamido)quinoline anion) (1) and the corresponding manganese(III) Schiff base compound. Complexes 2and 3containa cyanide-bridged heterobimetallic dinuclear entity, which can be further dimerized by self-complementary H-bond interactions through the coordinated water molecule from one complex and the free O4unit from the adjacent complex. Complexes 4 and 5 area one-dimensional coordination polymer (CP) comprised of the repeated [Mn(Schiffbase)-Fe(qxcq)(CN)3] units. Complex 4 shows a linear-chain conformation with two trans-located cyano groups bridgingthe neighboring Mn units, while complex 5 is a zigzag-like 1D CP, where the two cyano groups in cis configurationfunction as bridges. In bothcomplexes 4 and 5, the inter-chain π–πstack interactions within the aromaticrings of cyanide precursor extend the 1D chain into the supermolecular 2D networks. The magnetic property has been experimentally studied and theoretically fitted over the four Fe(III)-Mn(III) complexes, revealing the antiferromagnetic interaction in complexes 2 and 4 and the unusual ferromagnetic coupling in complexes 3 and 5 between the Fe(III) ion and the Mn(III) ion bridged by the cyano group. Furthermore, the different magnetic coupling nature has been analyzed on the basis of the magneto-structure correlation of the mer-tricyanometallate-based Fe(III)-Mn(III) magnetic system.

Thermo-sensitive luminescence of lanthanide complexes, clusters, coordination polymers and metal–organic frameworks with organic photosensitizers

Historical and recent advances of lanthanide mononuclear complexes, polynuclear clusters, coordination polymers (CPs) and metal–organic frameworks (MOFs) with temperature-dependent luminescence are reviewed for future thermo-sensitive paints.

Pre-programmed self-assembly of polynuclear clusters

This perspective reviews our recent efforts towards the self-assembly of polynuclear clusters with ditopic and tritopic multidentate ligands HL1 (2-phenyl-4,5-bis{6-(3,5-dimethylpyrazol-1-yl)pyrid-2-yl}-1H-imidazole) and H2L2 (2,6-bis-[5-(2-pyridinyl)-1H-pyrazole-3-yl]pyridine), both of which are planar and rigid molecules.