First Record of the Asian Longhorned Tick Haemaphysalis longicornis in Missouri

ABSTRACT The Asian longhorned tick, Haemaphysalis longicornis, is an invasive species, originally from eastern Asia, and was first reported in the USA in New Jersey. It is now reported in several eastern states. In 2018, researchers reported H. longicornis in northwest Arkansas (Benton County). This tick species is a proven vector of livestock and human diseases, which prompted the current survey of ticks in southwest Missouri. A tick drag in Greene County, Missouri, produced 2 H. longicornis nymphs on June 9, 2021. This is the first report of this species for both the state and county.

The Value of Fathering for Incarcerated Offenders: Implementing the “Parents as Teachers” Curriculum in Greene County, Missouri

Research literature demonstrates the positive contributions of a nurturing father in the lives of young people as well as the reduction of recidivism for active fathers. The current study provides support for this model by highlighting the need for programming that enhances the relationship between incarcerated fathers and their children during their period of absence and while transitioning back into society and their family roles. The authors observed a parenting education program for incarcerated fathers twice weekly for a period of twelve weeks. The research noted three promising themes in the programming which could be expanded and implemented in other facilities. Fathers sought to improve their capacity to engage in “intentional conversations,” where they learned about modeling desirable behavior, being honest, and avoiding giving children mixed messages. Fathers also began the uncomfortable process of unpacking their own childhoods and overcoming poor parental models as they realized that “parenting makes a difference.” Through the program, fathers were encouraged to develop a “toolkit” of more positive parenting responsibilities and responses. Finally, fathers were introduced to the idea of “healthy relationships,” including creating strong boundaries and new types of relationship knowledge.

The Private School Pivot: The Shrouded Persistence of Massive Resistance in the Black Belt and Beyond

In 1969, four years after passage of the Voting Rights Act, African Americans in Greene County, Alabama, reclaimed control of local government, becoming the first community in the South to do so since Reconstruction. A half century later, however, Greene County remains an impoverished and largely segregated area with poor educational outcomes, especially for Black children. This essay explores the history of Greene County from 1954 to the recent past, with a particular focus on Warrior Academy, a segregated private school (“segregation academy”) founded by Whites in 1965. As a case study of “school choice” in the context of the “long civil rights movement,” it complicates scholarly definitions of “massive resistance.” Furthermore, it demonstrates the ways in which an emerging “color-blind” conservatism premised on White concerns about “educational quality” thwarted Black efforts to achieve educational equality, even in places where African Americans achieved significant political victories.

Potential Docking Affinity of Three Approved Drugs Against SARS-CoV-2 for COVID-19 Treatment

<p>Potential Docking Affinity of three Approved Drugs against </p> <p>SARS-CoV-2 for COVID-19 treatment.</p> <p> </p> <p>Venkata Sambasiva Rao Rachakulla¹, Hemanjali Devi Rachakulla²</p> <p>¹Department of Math, Greene County High School, Greensboro, GA, 30642 USA.</p> <p>²Department of Science, Jonesboro High School, Jonesboro, GA, 30236, USA.</p> <p>¹Author for correspondence email: <a href="mailto:[email protected]">[email protected]</a></p> <p>²Author email: <a href="mailto:[email protected]">[email protected]</a></p> <p><b>Abstract</b><b></b></p> <p><b>Objectives</b>: The availability of a safe and effective drug for COVID-19 is well-recognized as an additional tool to contribute to the control of the pandemic. At the same time, the challenges and efforts needed to rapidly develop, evaluate, and produce this at scale are enormous. It is vital that we evaluate as many vaccines as possible as we cannot predict how many will turn out to be viable.</p> <p><b>Methods</b>: In this study, we have measured the virtual interaction of crystal data structures of protein downloaded from protein data bank <a>(PDB ID 7BRP)</a> with corticosteroid drug candidates approved by FDA for other medical purposes which have less side effects. The results are analyzed in contrast some drugs candidates currently using for the treatment of COVID-19.</p> <p><b>Results</b>: The binding energies in kilocalories/mole obtained from the docking of 7BRP protease with ligands under investigation Betamethasone Phosphate (-6.9), Fluticasone (-6.1) and Dexamethasone (-5.9) and also with currently using drug candidates Remdesivir(-6.5), Lopinavir (-6.0), Baceprivir(-5.7), Rabavirin(-6), Ritinovir(-5.3), Hydroxyquinoline(-5.0), Chloroquine (-4.7), Oseltamivir(-4.6), Favipiravir(-3.9). </p> <p><b>Discussion:</b> The docking results suggest a higher binding affinity of the drug molecules under investigation against SARS-CoV-2 in contrast with other drug candidates currently being used for the treatment of COVID-19. We have analyzed bond interactions of protein-ligand from images in 10 modes of investigated drugs in contrast with Remdesivir and also discussed the advantages of inhalation methods of drug fluticasone. </p> <p>Conclusion: From this study, it can be suggested that these drugs are promising candidates for antiviral treatment with high potential to fight against SARS-CoV-2 strain keeping in view various ways of administration of drugs currently practicing.</p>

Potential Docking Affinity of Three Approved Drugs Against SARS-CoV-2 for COVID-19 Treatment

<p>Potential Docking Affinity of three Approved Drugs against </p> <p>SARS-CoV-2 for COVID-19 treatment.</p> <p> </p> <p>Venkata Sambasiva Rao Rachakulla¹, Hemanjali Devi Rachakulla²</p> <p>¹Department of Math, Greene County High School, Greensboro, GA, 30642 USA.</p> <p>²Department of Science, Jonesboro High School, Jonesboro, GA, 30236, USA.</p> <p>¹Author for correspondence email: <a href="mailto:[email protected]">[email protected]</a></p> <p>²Author email: <a href="mailto:[email protected]">[email protected]</a></p> <p><b>Abstract</b><b></b></p> <p><b>Objectives</b>: The availability of a safe and effective drug for COVID-19 is well-recognized as an additional tool to contribute to the control of the pandemic. At the same time, the challenges and efforts needed to rapidly develop, evaluate, and produce this at scale are enormous. It is vital that we evaluate as many vaccines as possible as we cannot predict how many will turn out to be viable.</p> <p><b>Methods</b>: In this study, we have measured the virtual interaction of crystal data structures of protein downloaded from protein data bank <a>(PDB ID 7BRP)</a> with corticosteroid drug candidates approved by FDA for other medical purposes which have less side effects. The results are analyzed in contrast some drugs candidates currently using for the treatment of COVID-19.</p> <p><b>Results</b>: The binding energies in kilocalories/mole obtained from the docking of 7BRP protease with ligands under investigation Betamethasone Phosphate (-6.9), Fluticasone (-6.1) and Dexamethasone (-5.9) and also with currently using drug candidates Remdesivir(-6.5), Lopinavir (-6.0), Baceprivir(-5.7), Rabavirin(-6), Ritinovir(-5.3), Hydroxyquinoline(-5.0), Chloroquine (-4.7), Oseltamivir(-4.6), Favipiravir(-3.9). </p> <p><b>Discussion:</b> The docking results suggest a higher binding affinity of the drug molecules under investigation against SARS-CoV-2 in contrast with other drug candidates currently being used for the treatment of COVID-19. We have analyzed bond interactions of protein-ligand from images in 10 modes of investigated drugs in contrast with Remdesivir and also discussed the advantages of inhalation methods of drug fluticasone. </p> <p>Conclusion: From this study, it can be suggested that these drugs are promising candidates for antiviral treatment with high potential to fight against SARS-CoV-2 strain keeping in view various ways of administration of drugs currently practicing.</p>