dna analogs
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2017 ◽  
Vol 53 (73) ◽  
pp. 10156-10159 ◽  
Author(s):  
Zhenzhen Liu ◽  
Benjamin Fairbanks ◽  
Liangcan He ◽  
Tao Liu ◽  
Parag Shah ◽  
...  

Water-soluble single stranded DNA analogs are generated via thiol–ene photo-oligomerization.


2015 ◽  
Vol 21 (5) ◽  
pp. 303-314 ◽  
Author(s):  
Barbara Nawrot ◽  
Olga Michalak ◽  
Barbara Mikołajczyk ◽  
Wojciech J. Stec

AbstractTris-(hydroxymethyl)phosphine oxide (THPO) to a certain extent resembles a part of 2′-deoxyribofuranose, although it exists in an acyclic form only and the oxygen atom at the THPO phosphorus center provides additional hydration site or acceptor of hydrogen bonds. After proper protection of hydroxyl groups, THPO was functionalized with nucleobases and converted into phosphoramidite monomers suitable for incorporation into growing oligonucleotide chains within the solid phase synthesis protocol. The resultant THPO-DNA analogs show reduced affinity to complementary DNA strands, and are resistant towards snake venom and calf spleen exonucleases.


2015 ◽  
Vol 43 (14) ◽  
pp. 6994-7004 ◽  
Author(s):  
Shristi Pandey ◽  
Anna M. Ogloblina ◽  
Boris P. Belotserkovskii ◽  
Nina G. Dolinnaya ◽  
Marianna G. Yakubovskaya ◽  
...  

2012 ◽  
Vol 7 (3) ◽  
pp. 1934578X1200700
Author(s):  
Eri Noguchi ◽  
Narumi Shigi ◽  
Makoto Komiyama

Peptide nucleic acid (PNA) is one of the most useful DNA analogs in a wide variety of gene analysis in human cells. In order to exhibit its maximal functions, PNA must be localized to a desired place (e.g., nucleus, cytoplasm and other organelles). Here, we introduced PNAs into HeLa cells by electroporation and examined their localization at various time points. The PNA which binds to the mitochondrial COII gene was initially accumulated in the nucleus, and thereafter mostly transferred to cytoplasm. This time-dependent intracellular localization of PNA is ascribed to the breakdown of the nuclear envelope in the cell division. On the other hand, another PNA that binds to telomere repeat sequence mostly remained in the nucleus, even after the cell division occurred. The retention of this PNA in the nucleus was further enhanced when it was conjugated with Cy3.


Biopolymers ◽  
2010 ◽  
Vol 93 (10) ◽  
pp. 880-886 ◽  
Author(s):  
Janos Sagi ◽  
Daniel Renčiuk ◽  
Martin Tomaško ◽  
Michaela Vorlíčková
Keyword(s):  

Science ◽  
2009 ◽  
Vol 325 (5936) ◽  
pp. 9.1-9
Keyword(s):  

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