Adaptable DNA Analogs

Science ◽  
2009 ◽  
Vol 325 (5936) ◽  
pp. 9.1-9
Keyword(s):  
Dna Analogs

Quadruplexes of human telomere DNA analogs designed to contain G:A:G:A, G:G:A:A, and A:A:A:A tetrads

Biopolymers ◽  
2010 ◽  
Vol 93 (10) ◽  
pp. 880-886 ◽  
Author(s):  
Janos Sagi ◽  
Daniel Renčiuk ◽  
Martin Tomaško ◽  
Michaela Vorlíčková
Keyword(s):  
Dna Analogs ◽  
Human Telomere

scholarly journals Inhibition of the multiple antibiotic resistance (mar) operon in Escherichia coli by antisense DNA analogs.

1997 ◽  
Vol 41 (12) ◽  
pp. 2699-2704 ◽  
Author(s):  
D G White ◽  
K Maneewannakul ◽  
E von Hofe ◽  
M Zillman ◽  
W Eisenberg ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Antisense Oligonucleotides ◽  
Multiple Antibiotic Resistance ◽  
Wild Type ◽  
Lacz Expression ◽  
E Coli ◽  
Plasmid Construct ◽  
Dna Analogs ◽  
Susceptibility And Resistance

The multiple antibiotic resistance operon (marORAB) in Escherichia coli controls intrinsic susceptibility and resistance to multiple, structurally different antibiotics and other noxious agents. A plasmid construct with marA cloned in the antisense direction reduced LacZ expression from a constitutively expressed marA::lacZ translational fusion and inhibited the induced expression of LacZ in cells bearing the wild-type repressed fusion. The marA antisense construction also decreased the multiple antibiotic resistance of a Mar mutant. Two antisense phosphorothioate oligonucleotides, one targeted to marO and the other targeted to marA of the mar operon, introduced by heat shock or electroporation reduced LacZ expression in the strain having the marA::lacZ fusion. One antisense oligonucleotide, tested against a Mar mutant of E. coli ML308-225, increased the bactericidal activity of norfloxacin. These studies demonstrate the efficacy of exogenously delivered antisense oligonucleotides targeted to the marRAB operon in inhibiting expression of this chromosomal regulatory locus.

Structural RNA Mimetics:  N3‘ → P5‘ Phosphoramidate DNA Analogs of HIV-1 RRE and TAR RNA Form A-Type Helices That Bind Specifically to Rev and Tat-Related Peptides†

Biochemistry ◽  
1997 ◽  
Vol 36 (3) ◽  
pp. 650-659 ◽  
Author(s):  
C. Ted Rigl ◽  
David H. Lloyd ◽  
Dean S. Tsou ◽  
Sergei M. Gryaznov ◽  
W. David Wilson
Keyword(s):  
Dna Analogs ◽  
Tar Rna ◽  
Hiv 1

scholarly journals Transcription blockage by stable H-DNA analogs in vitro

2015 ◽  
Vol 43 (14) ◽  
pp. 6994-7004 ◽  
Author(s):  
Shristi Pandey ◽  
Anna M. Ogloblina ◽  
Boris P. Belotserkovskii ◽  
Nina G. Dolinnaya ◽  
Marianna G. Yakubovskaya ◽  
...  
Keyword(s):  
Dna Analogs ◽  
Transcription Blockage

Analysis of Oligonucleotides and Antisense DNA Analogs

1997 ◽  
pp. 177-194
Author(s):  
Aran Paulus ◽  
Gerard J. M. Bruin ◽  
Iris Barmé ◽  
Angelika Muscate ◽  
Markus Ehrat
Keyword(s):  
Dna Analogs ◽  
Antisense Dna

A Novel Class of DNA Analogs Bearing 5′-C-Phosphonothymidine Units: Synthesis and Physicochemical and Biochemical Properties

2006 ◽  
Vol 16 (1) ◽  
pp. 68-82 ◽  
Author(s):  
Barbara Nawrot ◽  
Milena Sobczak ◽  
Marzena Wójcik ◽  
Magdalena Janicka ◽  
Marian Nowak ◽  
...  
Keyword(s):  
Biochemical Properties ◽  
Dna Analogs

scholarly journals Toward replicatable, multifunctional, nanoscaffolded machines. A chemical manifesto

2003 ◽  
Vol 75 (5) ◽  
pp. 609-619 ◽  
Author(s):  
G. von Kiedrowski ◽  
L.-H. Eckardt ◽  
K. Naumann ◽  
W. M. Pankau ◽  
M. Reimold ◽  
...  
Keyword(s):  
Microelectrode Array ◽  
Gold Cluster ◽  
Building Blocks ◽  
Gold Clusters ◽  
Inductive Heating ◽  
Dna Nanostructures ◽  
Modular Functions ◽  
Polymeric Networks ◽  
Dna Analogs ◽  
Implementation Scheme

Self-replicating nanorobots were foreseen in technological dreams and visions whose scientific ground found solid criticism from chemical and physical reasoning. If one, however, views such constructs as three-dimensionally defined noncovalent nanoscaffolding of a multitude of modular functions whose array is replicatable in a nonautonomous way, many pieces of technology needed for their implementation became recently available. Gold cluster-labeled molecules were remotely controlled by GHz radio frequency causing local and selective inductive heating, and monoconjugable thermostable gold clusters will become commercially available soon. Charged molecules were electrophoretically steered and manipulated on the surface of microelectrode array chips. Surface-promoted replication and exponential amplification of DNA analogs (SPREAD) may find particular applications for the cloning and copying of informational nanostructures on the surface of such chips. Synthetic trisoligonucleotidyl junctions were reported as covalent building blocks for noncovalent DNA nanostructures, and it was shown that kinetic control during noncovalent synthesis favors small and defined nanostructures instead of polymeric networks. Very recently, it was demonstrated that functionalized DNA nanoscaffolds with stiff tensegrity such as tetrahedra self-assemble from maximally instructed sets of 3- or [3+1]-arm junctions, and that the connectivity information in such nanoscaffolds can be copied. The implications of these developments are discussed with respect to a possible implementation scheme for the issue of the title.

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