Embolization of Type 2 Endoleaks in the Abdominal Aorta Using Ethylene Vinyl Alcohol Copolymer

Background Type 2 endoleaks (T2EL) are the most frequent complication following endovascular aortic repair. Multiple studies primarily deal with the technical and clinical success of the embolization of persisting T2EL, thereby revealing controversial outcomes. Current reports rarely focus on the detailed execution of such a complex interventional procedure with respect to the difficult anatomic setting. Methods The present review provides an in-depth depiction and evaluation of the interventional methodology of the embolization of T2EL in the abdominal aorta with use of ethylene vinyl alcohol copolymer (EVOH). Complicating anatomic conditions are taken into account as well as technical and clinical success rates. Results Using the transarterial approach, there are at least 4 different pathways to access the nidus of a T2EL. CT-guided direct puncture of the aneurysm sac provides an alternative method of high technical success. EVOH with its slow solidification characteristics enables good control to achieve complete filling of the T2EL. During the intervention, however, it remains difficult to meet exactly the embolization endpoint, especially in large T2ELs. Conclusion T2EL embolization using EVOH is an effective treatment with low major complication rates when conducted by skilled interventionists with detailed knowledge of diverse complex access routes. Key Points: Citation Format

Antimicrobial materials produced by incorporating copper acetate into ethylene-vinyl alcohol copolymer for its use in personal care and cosmetic packaging

Currently, there is a great demand for functional materials with effective pathogen-killing properties. In this research, we describe the use of green technology “reactive extrusion” for the synthesis of potent antimicrobial materials based on Ethylene-vinyl alcohol copolymer (EVOH). Herein, the antimicrobial agent, copper (II) acetate was used without pretreatment and introduced into the EVOH matrices at high temperatures. The thermal reaction of copper (II) acetate within the EVOH matrices and their effect on the thermal and thermomechanical properties of the polymer were investigated in regards to their concentration. The physicochemical, thermal, and rheological features, as well as, metal salt release kinetics were reported. The antimicrobial agent had significant effects on the properties of the matrix. Results showed a reduction in the glass transition temperatures and storage modulus of the materials in response to the incorporation of copper (II) acetate. Finally, the antimicrobial activity of the products was studied and demonstrated a possibility to create antimicrobial materials in a one-step, solvent-free extrusion process.