Intercellular Interactions in Peripheral Venous Blood in Practically Healthy Residents of High Latitudes

The paper presents the results of studying the immunological parameters of 369 people who were practically healthy at the time of the survey, 298 women and 71 men, of which 216 people are living in the European North of the Russian Federation (173 women and 43 men) and 153 are residents of the Arctic (125 women and 28 men). The study was carried out in the morning (08:00–10:00 am). The study included the determination of the aggregation of erythrocytes, platelets, neutrophilic granulocytes, lymphocytes, hemogram study, hematological analysis, enzyme immunoassay, and flow cytometry. Statistical processing of the obtained data was carried out using the Statistica 7.0 software package (StatSoft, USA). It was found that the activity of aggregation of cells of peripheral venous blood in Arctic residents is 1.5–1.7 times higher than that in people living in more favourable climatic conditions. The frequency of registration of aggregation of erythrocytes and platelets is actually 2 times higher than the aggregation of leukocytes. Aggregation of erythrocytes is associated with an increase in the concentrations of transferrin and receptors for this transport protein. The frequency of detection of platelet aggregation is accompanied by an increase in transferrin concentrations; in cases of aggregation of nonnuclear blood cells, the content of NO2 in the blood serum is increased. Aggregation of neutrophilic granulocytes and lymphocytes is associated with an increase in the content of free adhesion molecules. Aggregation of erythrocytes and platelets is in evidence when it is necessary to trigger reactions of changes in the hemodynamics of microcirculation to increase the efficiency of oxygen and trophic supply of tissues. The adhesion of leukocytes to the endothelium determines the secretion of biologically active substances that contribute to a change in microcirculation and an increase in the migration of leukocytes into tissues for the implementation of phagocytic and cytolytic functions.

MACRO-AND MICROSCOPIC CHANGES KIDNEY DISEASE IN CORONAVIRUS INFECTION COVID-19

В настоящее время глубоко изучается морфо и патогенез - короновирусной инфекции, представители мировой медицины отмечают, что вирус SARS-Cov-2 очень быстро распространяется от человека к человеку. В связи с этим ВОЗ объявила вспышку COVID-19 пандемией. Некоторые ученые разработали концепцию, согласно которой изменение функциональной функции почек,изменение цвета мочи от нормального состояния, увеличение концентрации альбумина происходят от проникновения специфического SARS-CoV-2 в клетку через рецепторы АСЕ2.Доказано, что при цитологическом исследовании почек у человека в тяжелом состоянии COVID-19 происходит агрегация эритроцитов, разрушение эпителия и подоцитов. Лицам, страдающим хроническими заболеваниями почек, необходимо применять безопасные и действенные - методические подходы в профилактике короновирусной инфекции. At present, the pathogenesis and morphogenesis of coronavirus infections are being studied in-depth, and the SARS-Cov-2 virus is spreading rapidly from person to person, according to world medicine. In this regard, the WHO declared the COVID-19 epidemic a pandemic. Some scientists have suggested that changes in renal function, abnormal urine colour, and increased albumin concentrations are caused by the entry of specific SARS-CoV-2 into the cell through ACE2 receptors. Cytological examination of the kidneys has shown that a person with severe COVID-19 has aggregation of erythrocytes, destruction of epithelium and podocytes. People with chronic kidney disease should use safe and effective innovative methods in the prevention of coronavirus infection.