Effect of mulmina mango as an adjunct to standard of care treatment on COVID-19 positive subjects undergoing treatment for COVID-19 in hospital quarantine (Dedicated Covid Health Centre)

There are no approved drugs to treat COVID-19, and the vaccine is likely to be ready by early 2021. Many clinical studies are ongoing around the globe to find a cure or prevention of the disease. The objective of the proposed study is to determine the efficacy and safety profile of Mulmina Mango as an adjunct to standard of care treatment on COVID-19 positive subjects undergoing treatment for COVID-19 in Hospital Quarantine. Settings and Design: The enrolled subjects were randomized into either of the two treatment arms in the ratio of 1:1. The freshly diagnosed (24-48 hrs.) COVID-19 positive Male or Female is aged 20 to 65 years (both inclusive) hospitalized patients were approached and checked for their eligibility. They were recruited after signing the written informed consent form. The number of patients included in the study is 48. In efficacy, both the treatment arms and the reduction in clinical symptom scale value and ordinal scale value are seen on day 7. On the ordinal scale, 41.7% of subjects in Treatment arm A showed a reduction of 2 points on the day, and 16.7% of subjects show 2 points reduction in Treatment arm B. In Safety results, there was no clinically significant finding in safety parameters in Treatment arm B. Mulmina Mango showed encouraging results concerning RTPCR, CRP, Dopamine, IgG, CD4, and CD8 parameters. The properties of Mulmina Mango are highlighted below, along with the parameters for each property. Mulmina Mango, COVID-19, Treatment Arm A, Treatment Arm B, MoHFW (Ministry of Health and Family Welfare)

An integrative approach to clinical recovery for COVID-19 patients using an Ayurvedic formulation: A multicentric double-blind randomized control trial.

BackgroundTraditional medicine systems such as Ayurveda contain a vast repository of naturally occurring herbs with strong antimicrobial potency. A multitude of complementary therapies have been explored for their therapeutic role to treat COVID-19 during the pandemic. There have been promising results reported from in silico, in vitro and in vivo studies that need to be further explored in humans.ObjectiveThe present randomized placebo control trial evaluates the clinical efficacy of an integrated approach including Ayurvedic polyherbal formulation, NOQ19 in the improvement of mild to moderate category of COVID-19 infected patients.Patients and methodsA multicentric, randomized, placebo control design was adopted for the study. A total of 76 patients with positive COVID-19 RT-PCR test were enrolled in the study; 39 in the NOQ19 arm and 37 in the placebo arm. Patients were randomized and blinded to their respective intervention, which was provided along with the standard of care treatment. Rate of recovery assessment was done on Day 3, 5 and 7 via RT-PCR test to measure the rate of recovery. Blood markers were analysed on Day 0 and Day 7.OutcomesThe patients were assessed for rate of recovery via RT-PCR and improvement in blood biomarkers. They were also monitored for any adverse events or side effects of the drug.ResultsThe present study demonstrated a significant early recovery in the patients who took the NOQ19 formulation. Patients who received NOQ19 with the standard care of treatment showed clinical improvement in terms of oxygen requirement, breathlessness and SpO2, though the difference was not statistically significant. Moreover, no side effects were observed with the use of NOQ19.ConclusionAn overall integrated approach of standard of care treatment with Ayurvedic formulation (NOQ19) results in early clinical outcome in the management of mild to moderate cases of COVID-19.

Ayurveda and Management of COVID-19 in Rural Indian Population: A pilot, double blind, randomized control trial

Background The SARS-CoV-2 virus responsible for the COVID-19 pandemic is a highly contagious and rapidly mutating virus. The COVID-19 pandemic has affected millions globally over the last 18 months and continues to overwhelm the healthcare system in several countries to date. The healthcare and scientific community has been vigorously searching for ways to manage the disease. Several solutions based on traditional systems of medicine like Ayurveda are also being explored for their effectiveness in managing COVID-19. The study explored the efficacy of a 19 ingredient Ayurvedic polyherbal formulation called NOQ19, on the recovery of mild, RT-PCR positive COVID-19 patients. Methods This was a prospective, double blind, randomized control trial that included 92 patients with a RT-PCR positive mild case of COVID-19. The patients were enrolled from rural areas of Karnataka, a state in India. The patients were randomized between the NF2 and placebo arms, in a 1:1 ratio, and were provided their respective intervention, along with the standard of care treatment (SOC). The trial took place at the Community Care Center, Konnanuru, Hassan, Karnataka. The study duration was around 2 months and the follow-up period for an individual patient was 14 days. RT-PCR analysis was done at baseline, Day 3, 7 and 10. Blood markers to track inflammation were assessed at baseline, Day 3 and 7. Result A statistically significant difference was observed between the two groups with regards to the percentage of population who turned RT-PCR negative on Day 3 and Day 10. On all three assessment time points (Day 3, 7 and 10), the NF2+SOC arm showed a greater percentage of population who were RT-PCR negative compared to the placebo+SOC arm: Day 3 (NF2 -19%, Placebo - 0%) ; Day 7 (NF2- 41%, Placebo - 19%) ; Day 10 (NF2-73%, Placebo 44%). No significant changes were observed in blood markers for both the groups. Conclusion NF2 administered along with standard of care treatment aided early recovery from COVID-19 as demonstrated by a higher percentage of population who were RT-PCR negative on Day 3, 7 and 10. No side effects were observed during the entire study duration. Early recovery of patients is essential for rational usage of limited healthcare resources in a pandemic.

Evaluation of an Ayurvedic formulation in clinical recovery of COVID-19 patients: A placebo controlled pilot study among moderate-severe patients

Introduction: The COVID-19 pandemic is a global health crisis that has affected millions of people worldwide. Apart from measures taken to reduce the transmission of virus and provide symptomatic relief to patients, a potent drug targeted against the virus is required to manage the disease. Traditional medicines with an array of phytochemicals and potent anti-viral properties, can provide alternate solution in the therapeutic cure of COVID-19.Objective: The present study investigates the efficacy of an Ayurvedic formulation, NOQ19, on the rate of recovery and clinical improvement among moderate-severe COVID-19 infected patients who were not on a ventilator or in intensive care unit.Methods: A placebo controlled randomized study design, with 1:1 ratio between the intervention and placebo arms was adopted. The participants were provided their respective intervention along with the standard of care treatment. A follow up was conducted on Day 7 and Day 10 to assess the rate of recovery and clinical improvement. Rate of recovery was the primary outcome measured and was determined by a negative result on the RT-PCR test. The secondary outcomes included clinical improvement among patients and were measured using blood biomarkers.Results: The NOQ19 arm had a higher percentage of population who turned RT-PCR negative on Day 7 (23%) when compared to the placebo arm (11%). Further subgroup analysis demonstrated that for both moderate and severe patients, there were a greater percentage of population who were RT-PCR negative in the NOQ19 arm compared to the placebo arm at Day 7: (NOQ-19: 22.22%, Placebo: 14.29% for moderate patients), (NOQ19: 23.08% Placebo: 0% for severe patients). By Day 10, both populations depicted an almost similar percentage of the population who were RT- PCR negative. Both the groups demonstrated an improvement in blood biomarkers, although the improvement was greater in the NOQ19 arm. None of the patients in the intervention arm reported any adverse events.Conclusion: The results of this pilot RCT indicates that NOQ19 along with standard of care treatment can be considered as an effective therapy for COVID-19 and aid early recovery from the disease.

PELATIHAN CARA PERAWATAN PAYUDARA PADA IBU HAMIL TRIMESTER III DI DESA BANTARJAYA KECAMATAN PEBAYURAN KABUPATEN BEKASI TAHUN 2021

ABSTRAKData Survei Demografi dan Kesehatan Indonesia tahun 2015 menyebutkan bahwa terdapat ibu nifas yang mengalami Bendungan ASI sebanyak 35.985 atau (15,60 %) ibu nifas (Meihartati, 2017). Hasil studi pendahuluan di Desa Bantarjaya tahun 2021 dengan wawancara dari 10 ibu menyusui, 7 ibu menyusui yang mengalami bendungan ASI dan penyebabnya pada saat hamil dan nifas tidak melakukan perawatan payudara. Perawatan payudara seharusnya dilakukan saat kehamila secara teratur agar produksi ASI saat menyusui cukup. Tujuan kegiatan ini adalah agar ibu hamil bisa melakukan perawatan payudara secara rutin untuk persiapan ibu saat menyusui karena pentingnya ASI maka dilakukan Pelatihan Perawatan Payudara Pada Ibu Hamil Trimester III Di Desa Bantarjaya Kecamatan Pebayuran Kabupaten Bekasi Tahun 2021.Kegiatan dilaksanakan pada hari Jumat 21 Mei 2021, bertempat di Balai Desa Bantar Jaya Kecamatan Pebayuran. Sasaran kegiatan ini adalah ibu hamil trimester III yang bertempat tinggal di Desa Bantar Jaya sebanyak 43 orang. Metode kegiatan yang digunakan dalam pengabdian ini ada berupa pelatihan cara perawatan payudara pada ibu hamil trimester III di Desa Bantarjaya Kecamatan Pebayuran Kabupaten Bekasi tahun 2021. Alat yang digunakan berupa alat peraga (phantom), video cara perawatan payudara, leafleat dan poster yang terkait materi yang akan disampaikan dalam pelatihan tersebut.Hasil nilai pretest dan posttest dari 43 responden memiliki pengetahuan sedang tentang cara perawatan payudara yaitu nilai rata-rata sebesar 75,96%, setelah penyuluhan nilai rata-rata menjadi 90,4% (Pengetahuan Baik). Berdasarkan nilai pretes dan posttest tersebut ada peningkatan pengetahuan dari responden (14,34%). Hasil nilai praktik menunjukkan sebelun dilakukan pelatihan, dari 43 responden memiliki keterampilan yang cukup dalam melakukan perawatan payudara (nilai rata-rata 75,2%), setelah evaluasi nilai rata-rata menjadi 97,7% (Keterampilan Baik). Ada peningkatan keterampilan dari responden setelah evaluasi (22,5%).Kegiatan pelatihan payudara pada ibu hamil trimester III untuk mempersiapkan ibu hamil dalam pemberian ASI Eksklusif pada masa nifas. Dalam kegiatan ini masih kurangnya pengetahuan dan kemampuan ibu hamil melakukan perawatan payudara. Dengan diadakannya pelatihan cara perawatan payudara bagi ibu hamil trimester III, dapat meningkatkan pengetahuan dan kemampuan ibu hamil dalam melakukan cara perawatan payudara. Kata Kunci : pelatihan; cara perawatan payudara; ibu hamil trimester III ABSTRACTAccording to the demography survey and Indonesian health in 2015, it stated that there were 35.985 or (15,60%) of the postpartum mothers encountered the dam breast milk (Meihartati, 2017). The preliminary study result in Bantar Jaya village, 2021 said that there were 7out 10 of Breast feeding mothers by interview had the dam breast milk. It was all because when they were pregnant and after the postpartum, they did not do the breast care treatment. In fact, the breast care treatment should be done regularly during the pregnancy in order to produce the enough breast milk. This activity aimed to encourage and support the pregnant women to do the breast care treatment regularly during the pregnancy. It was because breast milk was the important thing after the birth, so it required the training of breast care treatment to the third trimester of pregnant women in Bantar Jaya village Pabayuran district Bekasi regency 2021.The activity was conducted on Friday, 21st 2021 in village hall of Bantar Jaya, Pabayuran District. The target activity was 43 of third trimester of pregnant women who lived in Bantar Jaya Village. the method activity of this dedication applied the breast care training to the third trimester of pregnant women in Bantar Jaya Village, Pabayuran district, Bekasi Regency in 2021. The activity instruments were phantom, breast care treatment video, leaflet and poster which were filled by the training materials.The pretest and posttest result score stated that there 43 respondents which had the moderate knowledge of breast care, and it was 75, 96%. After the counseling, the 43 respondents’ knowledge increased to 90,4% (good knowledge). Based on the pretest and posttest, there was some enhancement of respondents’ knowledge to 14, 34%. The practical score showed that before having the counseling, the respondents only got the enough skill to do the breast care (the average score was 75,2%). However, after evaluating, the 43 respondents’ knowledge increased to 97, 7% (good skill). Furthermore, there was some skill enhancement of 43 respondents after having the evaluation (22, 5%).The breast care training activity to third trimester of pregnant women aimed to those pregnant women to get well prepared during pregnancy to do the exclusive breast feeding after the birth. In this activity, previously, they were still lack of breast care knowledge. By having this activity, there was enhancement of knowledge and capability of pregnant women in doing the breast care treatmentKeywords: counseling; breast care treatment; third trimester of pregnant women

Selected factors determining the choice of cosmetic masks by cosmetologists

A very important issue in the practice of cosmetologists is the selection of an appropriate cosmetic mask at the end of each care treatment. Due to their effects, cosmetic masks can contain various active substances in different concentrations that are tailored to the needs of a given skin type. The aim of the study was to investigate what are the guidelines of cosmetologists while choosing cosmetic masks in a beauty salon and home care.

Death Be Not Proud: A Commentary on Muslim Acceptance of Death in the Intensive Care Unit

Technologies used in medicine have meant that treatments can keep people biologically alive but often fail to provide meaningful recovery and quality of life. Many of those from the Islamic faith have relied on these technologies for recovery on religious grounds, even when it may be against clinical advice. This commentary seeks to challenge this notion among many Muslims and suggests there is a psycho-spiritual motivation within the Islamic tradition in not pursuing intensive care treatment that is deemed futile by clinicians. A wish to embrace death in these situations should be expressed to loved ones, and the dying person’s loved ones should be encouraged to embrace death, in order to minimise harm from disagreements between clinical staff and family.