convex curvature
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2021 ◽  
Author(s):  
Donald F. Ready ◽  
Henry C. Chang

AbstractActomyosin contraction shapes the Drosophila eye’s panoramic view. The convex curvature of the retinal epithelium, organized in ∼800 close-packed ommatidia, depends upon a fourfold condensation of the retinal floor mediated by contraction of actin stress fibers in the endfeet of interommatidial cells (IOCs). How these tensile forces are coordinated is not known. Here, we discover a novel phenomenon: Ca2+ waves regularly propagate across the IOC network in pupal and adult eyes. Genetic evidence demonstrates that IOC Ca2+ waves are independent of phototransduction, but require inositol 1,4,5-triphosphate receptor (IP3R), suggesting these waves are mediated by Ca2+ releases from ER stores. Removal of IP3R disrupts stress fibers in IOC endfeet and increases the basal retinal surface by ∼40%, linking IOC waves to facilitating stress fiber contraction and floor morphogenesis. Further, IP3R loss disrupts the organization of a collagen IV network underneath the IOC endfeet, implicating ECM and its interaction with stress fibers in eye morphogenesis. We propose that coordinated Ca2+ spikes in IOC waves promote stress fiber contractions, ensuring an organized application of the planar tensile forces that condense the retinal floor.Summary StatementCa2+ waves have an important role in generating tensile forces to shape the Drosophila eye’s convex curvature. Coordinated Ca2+ spikes facilitate actomyosin contractions at the basal endfeet of interommatidial cells.


2020 ◽  
Vol 127 (7) ◽  
pp. 579-593
Author(s):  
Anders Aamand ◽  
Mikkel Abrahamsen ◽  
Mikkel Thorup

2017 ◽  
Vol 29 (11) ◽  
pp. 116106 ◽  
Author(s):  
Qian-cheng Wang ◽  
Zhen-guo Wang ◽  
Yu-xin Zhao

Soft Matter ◽  
2015 ◽  
Vol 11 (24) ◽  
pp. 4952-4961 ◽  
Author(s):  
Jongmin Kim ◽  
Myung Seok Oh ◽  
Chang-Hyung Choi ◽  
Sung-Min Kang ◽  
Moo Jin Kwak ◽  
...  

The geometry or degree of hydrophobic interaction in Janus microcylinders affects the formation of the assembled structures.


2014 ◽  
Vol 278 ◽  
pp. 693-700 ◽  
Author(s):  
R. Brian Jackson ◽  
Brian G. Woods ◽  
W.R. Marcum

2014 ◽  
Vol 7 (5) ◽  
pp. 1091-1107 ◽  
Author(s):  
Ben Andrews ◽  
Mat Langford
Keyword(s):  

2014 ◽  
Vol 7 (2) ◽  
pp. 407-433 ◽  
Author(s):  
Ben Andrews ◽  
Mathew Langford ◽  
James McCoy
Keyword(s):  

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