This study aims to develop practical worksheets and find out the feasibility of PBL lab workshaps with chemical material in life for student of 10th MIA Grade High School. This research is classified as a development research subjects from Public Senior High School 2 Maumere and St. Gabriel Maumere High School. Data collection techniques through interviews, observation and questionnaire with instruments in the form of interview sheets, validation data analysis using Aiken Formula, while the feasibility analysis is based on the feasibility category which refers to a scale of 5. The result showed that PBL based lab worksheet were developed by modifying the 4-D model, namely define, design dan develop. Based on the calculation of a practicum Student Worksheet valid with a value of 0,93. Student Worksheet practicum is suitable for use based on the assessment of students and teachers. Assessment of students on an individual scale, small group and field respectively 82,60, 83,60 dan 83,43. Teacher ratings at individual, small group and field scale were 138,00, 139,00 and 139,50 respectively.