The use of hypothiazide in the complex treatment of hypertension

A new sulfonamide drug with an effective diuretic property - hypothiazide (hydrochlorothiazide, hydrodiuryl, dichlotride), (6 chloro-7-sulfanyl-1, 2, 4-benzodihydrothiadiazine - 1,1-dioxide) was synthesized simultaneously, but independently, Stevens and Koenig in 1958.

Laser desorption single-conformation UV and IR spectroscopy of the sulfonamide drug sulfanilamide, the sulfanilamide–water complex, and the sulfanilamide dimer

We elucidate sulfanilamide's conformational preference and the noncovalent interactions of the sulfonamide group with single-conformation IR spectroscopy.

The NMR Study and Antimicrobial Activity of Some Schiff Bases Derived From Sulphonamide Drug

Some Schiff base compounds derived from sulfonamide drug were synthesized by reaction of 4-aminobenzenesulfonamide with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and 2-hydroxy benzaldehyde) in good yields. Characterization of synthesized compound was carried by elemental analysis, IR, 1H,13C, HSQC and HMBC- NMR spectroscopy. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus, Streptococcus sp., Bacillus subtillus, Escherichia coli and Klebsiella pneumonia. Additionally, the compounds were tested for antifungicidal activity against Candida krusei, Candida tropicalis, Aspergillus fumigates and Aspergillus niger.