Combined effect of dose gradient and rotational error on prescribed dose coverage for single isocenter multiple brain metastases in frameless stereotactic radiotherapy

Background To evaluate the combined effect of rotational error and dose gradient on target dose coverage in frameless stereotactic radiotherapy. Methods Three spherical targets of different diameters (1, 1.5, and 2 cm) were drawn and placed equidistantly on the same axial brain computed tomography (CT) images. To test the different isocenter-target distances, 2.5- and 5-cm configurations were prepared. Volumetric modulated arc therapy plans were created for different dose gradients from the target, in which the dose gradients were modified using the maximum dose inside the target. To simulate the rotational error, CT images and targets were rotated in two ways by 0.5°, 1°, and 2°, in which one rotation was in the axial plane and the other was in three dimensions. The initial optimized plan parameters were copied to the rotated CT sets, and the doses were recalculated. The coverage degradation after rotation was analyzed according to the target dislocation and 12-Gy volume. Results A shallower dose gradient reduced the loss of target coverage under target dislocation, and the effect was clearer for small targets. For example, the coverage of the 1-cm target under 1-mm dislocation increased from 93 to 95% by increasing the Paddick gradient index from 5.0 to 7.9. At the same time, the widely accepted necrosis indicator, the 12-Gy volume, increased from 1.2 to 3.5 cm3, which remained in the tolerable range. From the differential dose volume histogram (DVH) analysis, the shallower dose gradient ensured that the dose-deficient under-covered target volume received a higher dose similar to that in the prescription. Conclusions For frameless stereotactic brain radiotherapy, the gradient, alongside the margin addition, can be adjusted as an ancillary parameter for small targets to increase target coverage or at least limit coverage reduction in conditions with probable positioning error.

CycleGAN for interpretable online EMT compensation

Purpose Electromagnetic tracking (EMT) can partially replace X-ray guidance in minimally invasive procedures, reducing radiation in the OR. However, in this hybrid setting, EMT is disturbed by metallic distortion caused by the X-ray device. We plan to make hybrid navigation clinical reality to reduce radiation exposure for patients and surgeons, by compensating EMT error. Methods Our online compensation strategy exploits cycle-consistent generative adversarial neural networks (CycleGAN). Positions are translated from various bedside environments to their bench equivalents, by adjusting their z-component. Domain-translated points are fine-tuned on the x–y plane to reduce error in the bench domain. We evaluate our compensation approach in a phantom experiment. Results Since the domain-translation approach maps distorted points to their laboratory equivalents, predictions are consistent among different C-arm environments. Error is successfully reduced in all evaluation environments. Our qualitative phantom experiment demonstrates that our approach generalizes well to an unseen C-arm environment. Conclusion Adversarial, cycle-consistent training is an explicable, consistent and thus interpretable approach for online error compensation. Qualitative assessment of EMT error compensation gives a glimpse to the potential of our method for rotational error compensation.

Investigation on Modeling and Formation Mechanism of Dynamic Rotational Error for Spindle-Rolling Bearing System

In the field of precision machining, the spindle-rolling bearing (SRB) system is widely used on the machine tool as one of the most fundamental and important components. The rotational error motions of the SRB system have significant effects on the machining accuracy (contour accuracy and surface roughness). Over the past decades, much work has been focused on the measurement of spindle balancing and rotational error motions, the vibrations response induced by the nonlinear stiffness and surface waviness of the bearing. However, the formative mechanism of the rotational error motions for the SRB system is not well understood. In this paper, the dynamic model of the SRB system considering the bearing nonlinearity is established. Seeking to reveal the effects of surface waviness of the bearing raceway, unbalance mass and disturbance force on the dynamic rotational error, the modeling method and formative mechanism of the dynamic rotational error for the SRB system is explored both theoretically and experimentally. Then, numerical simulation is performed to analyze the influence of the bearing raceway waviness, unbalance mass and disturbance force on the dynamic rotational error. An experimental setup is established based on a typical SRB system and a series of experiments are carried out. The experimental results are in good agreement with the theoretical and simulation results, which can demonstrate the feasibility and validity of the modeling method. Furthermore, this method can be effectively applied to the design and development phases of an SRB system to improve dynamic rotational accuracy.

Evaluation of the effect of random setup errors on dose delivery in Intensity Modulated Radiotherapy

Aim: To conduct a study on the effect of random setup errors inpatient for dose delivery in Intensity Modulated Radiotherapy plans using Octavius 4D phantom.Materials and methods: 11 patients with cancer of H&N were selected for this study. An IMRT plan was created for each patient. The IMRT quality assurance plans were transferred to Mosaiq workstation in a linear accelerator. These plans were delivered at the reference treatment position. Subsequently, the QA plans were delivered on the Octavius 4D phantom after introducing errors in various translational and rotational directions. The setup inaccuracies introduced varied from 1 mm to 5 mm along X, Y. These setup uncertainties were then introduced along X and Y direction simultaneously in equal measures. Similarly, IMRT plans were delivered also after introducing roll and yaw rotation of 1, 2 and 3 degrees in phantom. The deviation of gamma indices at all these positions was analyzed with respect to the reference setup position.Results: The percentage of points passing the gamma acceptance criterion decrease as we increase the setup error. The change is found to be very insignificant with setup error up to 2 mm along X, Y or XY direction. Similarly, the rotational error of up to 3 degrees is found to be acceptable.Conclusions: Small setup (< 2 mm) correction in patients may not adversely affect the dose delivery. But an error of similar magnitude in 2 directions simultaneously has a much greater impact on IMRT dose delivery.