deoxy sugars
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Author(s):  
Carla Marino ◽  
Andrea Verónica V. Bordoni

Deoxy sugars represent an important class of carbohydrates, present in a large number of biomolecules involved in multiple biological processes. In various antibiotics, antimicrobials, and therapeutic agents the presence of...


2019 ◽  
Author(s):  
Patrícia Calado ◽  
Catarina Dias ◽  
Ana Marta Matos ◽  
Maria Teresa Blásquez-Sanchez ◽  
Alice Martins ◽  
...  
Keyword(s):  

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1129 ◽  
Author(s):  
Ewelina Krol ◽  
Ilona Wandzik ◽  
Gabriela Brzuska ◽  
Luděk Eyer ◽  
Daniel Růžek ◽  
...  

Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system. Although effective vaccines are available on the market, they are recommended only in endemic areas. Despite many attempts, there are still no specific antiviral therapies for TBEV treatment. Previously, we synthesized a series of uridine derivatives of 2-deoxy sugars and proved that some compounds show antiviral activity against viruses from the Flaviviridae and Orthomyxoviridae families targeting the late steps of the N-glycosylation process, affecting the maturation of viral proteins. In this study, we evaluated a series of uridine derivatives of 2-deoxy sugars for their antiviral properties against two strains of the tick-borne encephalitis virus; the highly virulent TBEV strain Hypr and the less virulent strain Neudoerfl. Four compounds (2, 4, 10, and 11) showed significant anti-TBEV activity with IC50 values ranging from 1.4 to 10.2 µM and low cytotoxicity. The obtained results indicate that glycosylation inhibitors, which may interact with glycosylated membrane TBEV E and prM proteins, might be promising candidates for future antiviral therapies against TBEV.


2018 ◽  
Vol 59 (37) ◽  
pp. 3428-3431 ◽  
Author(s):  
Gefei Li ◽  
Masato Noguchi ◽  
Kensuke Nakamura ◽  
Ryohei Hayasaka ◽  
Yuuki Tanaka ◽  
...  
Keyword(s):  

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1547 ◽  
Author(s):  
Ewelina Krol ◽  
Ilona Wandzik ◽  
Gabriela Pastuch-Gawolek ◽  
Boguslaw Szewczyk

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