Lectins ofMycobacterium tuberculosis– rarely studied proteins

The importance of bacterial lectins for adhesion, pathogenicity, and biofilm formation is well established for many Gram-positive and Gram-negative bacteria. However, there is very little information available about lectins of the tuberculosis-causing bacterium,Mycobacterium tuberculosis(Mtb). In this paper we review previous studies on the carbohydrate-binding characteristics of mycobacteria and relatedMtbproteins, discussing their potential relevance toMtbinfection and pathogenesis.

Design, synthesis, andin vitrobiological evaluation of novel benzimidazole tethered allylidenehydrazinylmethylthiazole derivatives as potent inhibitors ofMycobacterium tuberculosis

Development of novel chemical probe for antitubercular lead optimization.

A combination of docking and cheminformatics approaches for the identification of inhibitors against 4′ phosphopantetheinyl transferase ofMycobacterium tuberculosis

We integrated virtual screening,in vitroandex vivoapproaches to identify numerous potent inhibitory scaffolds againstM. tbPptT.