The COVID-19 Pandemic Seen from a Syndemic Perspective: The LGBTQIA2SP+ Community

An adverse condition or a disease can (either directly or indirectly) interact in a synergistic fashion with other adverse conditions or diseases/maladies, and co-cluster together with them: this fundamental observation is at the basis of the term “syndemic” (a portmanteau for “synergistic epidemic”) [...]

A Rare Case of Guillain-Barré Syndrome following COVID-19 Vaccination

Various vaccines against COVID-19 have been developed since SARS-CoV-2 emerged at the end of 2019. Their emergency administration in healthcare settings has been accompanied by numerous adverse effects. A case of Guillain-Barré syndrome following vaccination with Covishield is presented here to highlight this possible adverse condition.

Photo-thermally Switchable Peptide Nanostructures towards Modulating Catalytic Hydrolase Activity

Enzymes are the most efficient catalysts in nature that possess an impressive range of catalytic activities albeit limited by the stability in adverse condition. Functional peptides have emerged as alternative...

Statistics for Testing Under Adverse Conditions

Here, we develop a statistical basis for limited adverse testing. This type of testing simultaneously evaluates system performance against minimum requirements and minimizes costs, particularly for large-scale engineering projects. Because testing is often expensive and narrow in scope, the data obtained are relatively limited—precisely the opposite of the recent big data movement but no less compelling. Although a remarkably common approach for industrial and large-scale government projects, a statistical basis for adverse testing remains poorly explored. Here, we prove mathematically, under specific conditions, that setting each independent variable to an adverse condition leads to a similar level of adversity in the dependent variable. For example, setting all normally distributed independent variables to at least their 95th percentile values leads to a result at the 95th percentile. The analysis considers sample size estimates to clarify the value of replicates in this type of testing, determines how many of the independent variables must be set to adverse condition values, and highlights the essential assumptions, so that engineers, statisticians, and subject matter experts know when this statistical framework may be applied successfully and design testing to satisfy statistical requisites.

MENTAL STATE STUDENTS TEENAGERS: A RETROSPECTIVE ANALYSIS OF THE PREVALENCE OF BORDERLINE MENTAL PATHOLOGY

The comprehensive study included 128 adolescents aged 15-17 years, students of the pedagogical College and school sports, the obtained data compared with data from similar studies using standardized diagnostic approach, conducted in 1988 and 2003. Data on structure of boundary mental pathology and the addiсtion of disturbances, including information are provided. The conclusion about extremely adverse condition of mental health of teenagers of the surveyed contingent during 30 years and need of development and carrying out psychoprophylactic actions is drawn.