scholarly journals Statistics for Testing Under Adverse Conditions

Author(s):  
Leonard F. Pease ◽  
Kevin K. Anderson ◽  
Judith Ann Bamberger ◽  
Michael J. Minette

Abstract Here, we develop a statistical basis for limited adverse testing. This type of testing simultaneously evaluates system performance against minimum requirements and minimizes costs, particularly for large-scale engineering projects. Because testing is often expensive and narrow in scope, the data obtained are relatively limited—precisely the opposite of the recent big data movement but no less compelling. Although a remarkably common approach for industrial and large-scale government projects, a statistical basis for adverse testing remains poorly explored. Here, we prove mathematically, under specific conditions, that setting each independent variable to an adverse condition leads to a similar level of adversity in the dependent variable. For example, setting all normally distributed independent variables to at least their 95th percentile values leads to a result at the 95th percentile. The analysis considers sample size estimates to clarify the value of replicates in this type of testing, determines how many of the independent variables must be set to adverse condition values, and highlights the essential assumptions, so that engineers, statisticians, and subject matter experts know when this statistical framework may be applied successfully and design testing to satisfy statistical requisites.

Author(s):  
Elizabeth G. Atkinson ◽  
Adam X. Maihofer ◽  
Masahiro Kanai ◽  
Alicia R. Martin ◽  
Konrad J. Karczewski ◽  
...  

AbstractAdmixed populations are routinely excluded from medical genomic studies due to concerns over population structure. Here, we present a statistical framework and software package, Tractor, to facilitate the inclusion of admixed individuals in association studies by leveraging local ancestry. We test Tractor with simulations and empirical data focused on admixed African-European individuals. Tractor generates ancestryspecific effect size estimates, can boost GWAS power, and improves the resolution of association signals. Using a local ancestry aware regression model, we replicate known hits for blood lipids in admixed populations, discover novel hits missed by standard GWAS procedures, and localize signals closer to putative causal variants.


2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Imam Wibowo, M.Si ◽  
Rusma Patriansyah

The purpose of this research is to know the information about relationship between independent variables which are training (X1) and motivation (X2) with dependent variable which is employee performance (Y) of PT. Bakrie Pipe Industries Bekasi, both simultaneously and partially. Data collected from 78 employee of PT. Bakrie Pipe Industries Operating Division randomly using Slovin formula. Then all data was analyzed by using regression and statistical analysis using F-statistic to know the influence of independent variable simultaneously and t-statistic to know the influence of independent variable partially with using SPSS Ver. 22 software. The results of this research shown that: 1). Simultaneously, training and motivation have positive influence and significant to employee performance of PT. Bakrie Pipe Industries Bekasi. 2). Partially, training has positive influence and significant to employee performance of PT. Bakrie Pipe Industries Bekasi. 3). Partially, motivation has positive influence and significant to employee performance of PT. Bakrie Pipe Industries Bekasi.


Author(s):  
Gábor Bergmann

AbstractStudying large-scale collaborative systems engineering projects across teams with differing intellectual property clearances, or healthcare solutions where sensitive patient data needs to be partially shared, or similar multi-user information systems over databases, all boils down to a common mathematical framework. Updateable views (lenses) and more generally bidirectional transformations are abstractions to study the challenge of exchanging information between participants with different read access privileges. The view provided to each participant must be different due to access control or other limitations, yet also consistent in a certain sense, to enable collaboration towards common goals. A collaboration system must apply bidirectional synchronization to ensure that after a participant modifies their view, the views of other participants are updated so that they are consistent again. While bidirectional transformations (synchronizations) have been extensively studied, there are new challenges that are unique to the multidirectional case. If complex consistency constraints have to be maintained, synchronizations that work fine in isolation may not compose well. We demonstrate and characterize a failure mode of the emergent behaviour, where a consistency restoration mechanism undoes the work of other participants. On the other end of the spectrum, we study the case where synchronizations work especially well together: we characterize very well-behaved multidirectional transformations, a non-trivial generalization from the bidirectional case. For the former challenge, we introduce a novel concept of controllability, while for the latter one, we propose a novel formal notion of faithful decomposition. Additionally, the paper proposes several novel properties of multidirectional transformations.


2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Daniel E. Runcie ◽  
Jiayi Qu ◽  
Hao Cheng ◽  
Lorin Crawford

AbstractLarge-scale phenotype data can enhance the power of genomic prediction in plant and animal breeding, as well as human genetics. However, the statistical foundation of multi-trait genomic prediction is based on the multivariate linear mixed effect model, a tool notorious for its fragility when applied to more than a handful of traits. We present , a statistical framework and associated software package for mixed model analyses of a virtually unlimited number of traits. Using three examples with real plant data, we show that can leverage thousands of traits at once to significantly improve genetic value prediction accuracy.


1988 ◽  
Vol 32 (17) ◽  
pp. 1179-1182 ◽  
Author(s):  
P. Jay Merkle ◽  
Douglas B. Beaudet ◽  
Robert C. Williges ◽  
David W. Herlong ◽  
Beverly H. Williges

This paper describes a systematic methodology for selecting independent variables to be considered in large-scale research problems. Five specific procedures including brainstorming, prototype interface representation, feasibility/relevance analyses, structured literature reviews, and user subjective ratings are evaluated and incorporated into an integrated strategy. This methodology is demonstrated in the context of designing the user interface for a telephone-based information inquiry system. The procedure was successful in reducing an initial set of 95 independent variables to a subset of 19 factors that warrant subsequent detailed analysis. These results are discussed in terms of a comprehensive sequential research methodology useful for investigating human factors problems.


2020 ◽  
Vol 14 (2) ◽  
pp. 215-238
Author(s):  
Stephen Nettelhorst ◽  
Laura Brannon ◽  
Angela Rose ◽  
Whitney Whitaker

Purpose The purpose of this study is to investigate online viewers’ preferences concerning the number and duration of video advertisements to watch during commercial breaks. The goal of the investigations was to assess whether online viewers preferred watching a fewer number of advertisements with longer durations or a greater number of advertisements with shorter durations. Design/methodology/approach Two studies used experimental research designs to assess viewers’ preferences regarding advertisements. These designs used two independent variables and one dependent variable. The first independent variable manipulated the type of choice options given to online viewers (e.g. one 60 s or two 30 s advertisements). The second independent variable manipulated when the choice was given to online viewers (i.e. at the beginning of the viewing experience or in the middle of the experience). The dependent variable measured viewers’ choices concerning their preferred advertisement option. Findings The results across both studies found that participants made choices that minimized total advertisement exposure time when possible. When minimizing total exposure time was not possible, participants made choices that minimized the number of exposures instead. Originality/value These investigations extend the literature on advertisement choice by examining online viewers’ preferences about the format of their advertising experience rather than the content of the persuasive messages themselves. In addition, these investigations provide value by investigating viewers’ responses to stimuli within realistic online simulations rather than abstract hypotheticals.


Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Takayuki Suzuki ◽  
Takashi Nozawa ◽  
Mitsuo Sobajima ◽  
Takashi Ohori ◽  
Akira Matsuki ◽  
...  

Background: Population-based studies have shown good correlation between severity of atherosclerotic disease in one arterial bed and involvement of other vessels. However, in patients with coronary artery disease (CAD), it remains unclear whether atherosclerotic plaque in an artery might regress or progress in parallel with other vessels. Accordingly, the present study was performed in patients with CAD to compare changes in plaque volume (PV) between the left main (LMT) and right coronary arteries (RCA), thoracic descending aorta (TDA) and common carotid artery (CCA), and to clarify clinical factors and biomarkers which might affect changes in PV in each artery. Methods: Using 64-multislice computed tomography, PVs in each artery were determined before and after 2.0-year follow-up period in 52 patients with CAD (67.4±9.9yo). Based on our previous study using ultrasound, CCA-PV was determined at windows of 90–240HU and TDA-PV determined manually. Coronary soft plaque was determined at windows of 0–75HU. Plasma levels of hsCRP, matrix metalloproteinase (MMP)-9 and urinary 8-iso-prostaglandin F2 α (PGF) were determined at baseline. Results: At baseline, PVs of TDA were correlated with CCA-PV (r=0.38, p<0.02), but PVs of other arteries did not correlate to each other. Two-year later, PVs of LMT, RCA, TDA, and CCA were reduced in 41, 62, 27, and 39% of patients, respectively. Changes in LMT-PV were weakly related with those of TDA-PV (r=0.37, p=0.02) and RCA-PV (r=0.31, p=0.08), but there were no relation between other arteries. The multivariate analysis revealed that treatment with statin and low LDL-cholesterol (C, <100mg/dl) were independent variables regarding a reduction in DTA-PV, but, in LMT, only low LDL-C was independent variable. However, there were no independent variables in RCA or CCA. The ratio of soft PV to total PV was similar between LMT (45.2±7.1%) and RCA (45.7±4.9%) at baseline and was unchanged in the follow-up study. None of hsCRP, MMP-9 or PGF levels was related with PVs of any arteries at baseline and with changes in PVs. Conclusions: Regression of PV in one arterial bed dose not necessarily allow us to predict atherosclerotic changes in the other vessels. Major factors which affect changes in PV may not be homogeneous between arteries.


2018 ◽  
Vol 90 (3) ◽  
pp. 313-319 ◽  
Author(s):  
Charlotte Rosso ◽  
Raphael Blanc ◽  
Julien Ly ◽  
Yves Samson ◽  
Stéphane Lehéricy ◽  
...  

ObjectivesThe relationship between stroke topography (ie, the regions damaged by the infarct) and functional outcome can aid clinicians in their decision-making at the acute and later stages. However, the side (left or right) of the stroke may also influence the identification of clinically relevant regions. We sought to determine which brain regions are associated with good functional outcome at 3 months in patients with left-sided and right-sided stroke treated by endovascular treatment using the diffusion-weighted imaging-Alberta Stroke Program Early CT Score (DWI-ASPECTS).MethodsPatients with ischaemic stroke (n = 405) were included from the ASTER trial and Pitié-Salpêtrière registry. Blinded readers rated ASPECTS on day 1 DWI. Stepwise logistic regression analyses were performed to identify the regions related to 3-month outcome in left (n = 190) and right (n = 215) sided strokes with the modified Rankin scale (0–2) as a binary independent variable and with the 10 regions-of-interest of the DWI-ASPECTS as independent variables.ResultsMedian National Institute of Health Stroke Scale (NIHSS) at baseline was 17 (IQR: 12–20), median age was 70 years (IQR: 58–80) and median day-one NIHSS 9 (IQR: 4–18). Not all brain regions have the same weight in predicting good outcome at 3 months; moreover, these regions depend on the affected hemisphere. In left-sided strokes, the multivariate analysis revealed that preservation of the caudate nucleus, the internal capsule and the cortical M5 region were independent predictors of good outcome. In right-sided strokes, the cortical M3 and M6 regions were found to be clinically relevant.ConclusionCortical non-motors areas related to outcome differed between left-sided and right-sided strokes. This difference might reflect the specialisation of the dominant and non-dominant hemispheres for language and attention, respectively. These results may influence decision-making at the acute and later stages.Trial registration numberNCT02523261.


1981 ◽  
Vol 61 (1) ◽  
pp. 91-96 ◽  
Author(s):  
ESSI EVANS

Data were accumulated from published sources and were combined in order to estimate the effects of level of feed intake, dietary energy concentration, energy intake level and dietary forage percentage on rumen liquid turnover rates in sheep and cattle. The effects of the dietary parameters on liquid turnover rates were estimated by regression analysis, where all possible combinations of independent variables were considered. It was found that rumen liquid turnover rates increased (P < 0.05) as feed intake increased with both sheep (r = 0.610) and cattle (r = 0.715). From multiple regression analyses it was learned that the inclusion of independent variables that were related to the physical composition of the diet along with variables for intake improved the estimation of liquid turnover rates, although the independent variable related to ration composition differed between sheep and cattle. With data from sheep experiments, elevations in the digestible energy content of the diet depressed (P < 0.05) liquid turnover rate. Based upon data from cattle, decreases in the forage portion of the diet had a similar depressing (P < 0.05) effect.


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