pyruvate kinase m2
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Boronic acid derivative activates pyruvate kinase M2 indispensable for redox metabolism in oral cancer cells

2022 ◽  
pp. 128539
Author(s):  
Mohd Rihan ◽  
Lakshmi Vineela Nalla ◽  
Anil Dharavath ◽  
Sagarkumar Patel ◽  
Amit Shard ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Pyruvate Kinase ◽  
Acid Derivative ◽  
Boronic Acid ◽  
Redox Metabolism ◽  
Pyruvate Kinase M2 ◽  
Oral Cancer Cells

A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors

2022 ◽  
pp. 119206
Author(s):  
Andrew R. Lavik ◽  
Karen S. McColl ◽  
Fernanda O. Lemos ◽  
Martijn Kerkhofs ◽  
Fei Zhong ◽  
...  
Keyword(s):  
Pyruvate Kinase ◽  
Ip3 Receptors ◽  
Pyruvate Kinase M2

scholarly journals Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer’s disease

Cell Reports ◽  
2021 ◽  
Vol 37 (10) ◽  
pp. 110102
Author(s):  
Jonghee Han ◽  
Junho Hyun ◽  
Jaesang Park ◽  
Sunmin Jung ◽  
Yoonseo Oh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pyruvate Kinase ◽  
Memory Deficits ◽  
Gamma Secretase ◽  
Pyruvate Kinase M2

Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia

2021 ◽  
Vol 140 ◽  
pp. 250-266
Author(s):  
Mengmeng Li ◽  
Hongjian Lu ◽  
Xueyan Wang ◽  
Chengwei Duan ◽  
Xiangyang Zhu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Pyruvate Kinase ◽  
Pyruvate Kinase M2 ◽  
Activating Transcription Factor

scholarly journals Novel imidazopyrimidines-based molecules induce tetramerization of tumor pyruvate kinase M2 and exhibit potent antiproliferative profile

2021 ◽  
pp. 106112
Author(s):  
Sagarkumar Patel ◽  
Christoph Globisch ◽  
Priyanka Pulugu ◽  
Prasoon Kumar ◽  
Alok Jain ◽  
...  
Keyword(s):  
Pyruvate Kinase ◽  
Pyruvate Kinase M2

A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2

2021 ◽  
Author(s):  
Sahil Arora ◽  
Gaurav Joshi ◽  
Anuhar Chaturvedi ◽  
Michael Heuser ◽  
Santoshkumar Patil ◽  
...  
Keyword(s):  
Pyruvate Kinase ◽  
Medicinal Chemistry ◽  
Pyruvate Kinase M2

A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy

2021 ◽  
Author(s):  
Guan-Jun Yang ◽  
Jia Wu ◽  
Chung-Hang Leung ◽  
Dik-Lung Ma ◽  
Jiong Chen
Keyword(s):  
Pyruvate Kinase ◽  
Pyruvate Kinase M2

scholarly journals Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2

Redox Biology ◽  
2021 ◽  
pp. 102160
Author(s):  
Cheryl van de Wetering ◽  
Allison M. Manuel ◽  
Mona Sharafi ◽  
Reem Aboushousha ◽  
Xi Qian ◽  
...  
Keyword(s):  
Pyruvate Kinase ◽  
Glutathione S Transferase ◽  
Pyruvate Kinase M2
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