scholarly journals Pyruvate kinase M2 (PKM2) improve symptoms of post‐ischemic stroke depression by activating VEGF to mediate the MAPK/ERK pathway

2021 ◽  
Author(s):  
Yun Feng ◽  
Xuebin Li ◽  
Jie Wang ◽  
Xiaohua Huang ◽  
Lanqing Meng ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Pyruvate Kinase ◽  
Erk Pathway ◽  
Pyruvate Kinase M2

Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing

2021 ◽  
pp. 128062
Author(s):  
Rajkumar Patle ◽  
Shital Shinde ◽  
Sagarkumar Patel ◽  
Rahul Maheshwari ◽  
Heena Jariyal ◽  
...  
Keyword(s):  
Pyruvate Kinase ◽  
Boronic Acid ◽  
Oral Dosing ◽  
Pyruvate Kinase M2

scholarly journals Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect

2021 ◽  
Vol 30 ◽  
pp. 096368972110275
Author(s):  
Zhen Li ◽  
Lina Yang ◽  
Shuai Zhang ◽  
Jiaqi Song ◽  
Huanran Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Valproic Acid ◽  
Cancer Therapy ◽  
Pyruvate Kinase ◽  
Histone Deacetylases ◽  
Warburg Effect ◽  
Broad Class ◽  
Pyruvate Kinase M2 ◽  
Breast Cancer Cell Growth ◽  
The Warburg Effect

Energy metabolism programming is a hallmark of cancer, and serves as a potent target of cancer therapy. Valproic acid (VPA), a broad Class I histone deacetylases (HDACs) inhibitor, has been used as a therapeutic agent for cancer. However, the detail mechanism about the potential role of VPA on the Warburg effect in breast cancer remains unclear. In this study, we highlight that VPA significantly attenuates the Warburg effect by decreasing the expression of pyruvate kinase M2 isoform (PKM2), leading to inhibited cell proliferation and reduced colony formation in breast cancer MCF-7 and MDA-MB-231 cells. Mechanistically, Warburg effect suppression triggered by VPA was mediated by inactivation of ERK1/2 phosphorylation through reduced HDAC1 expression, resulting in suppressing breast cancer growth. In summary, we uncover a novel mechanism of VPA in regulating the Warburg effect which is essential for developing the effective approach in breast cancer therapy.

scholarly journals Parkin Regulates the Activity of Pyruvate Kinase M2

2016 ◽  
Vol 291 (19) ◽  
pp. 10307-10317 ◽  
Author(s):  
Kun Liu ◽  
Fanzhou Li ◽  
Haichao Han ◽  
Yue Chen ◽  
Zebin Mao ◽  
...  
Keyword(s):  
Pyruvate Kinase ◽  
Pyruvate Kinase M2
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