Organic fluorophore capped gold nanostars for enhanced detection of choroidal neovascularization in living rabbits using multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy

2020 ◽  
Author(s):  
Van Phuc Nguyen ◽  
Yanxiu Li ◽  
Jessica Henry ◽  
Michael Aaberg ◽  
Sydney Jones ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescence Microscopy ◽  
Choroidal Neovascularization ◽  
Optical Coherence ◽  
Photoacoustic Microscopy ◽  
Gold Nanostars ◽  
Organic Fluorophore

scholarly journals Integrating photoacoustic microscopy, optical coherence tomography, OCT angiography, and fluorescence microscopy for multimodal imaging

2020 ◽  
Vol 245 (4) ◽  
pp. 342-347 ◽  
Author(s):  
Arash Dadkhah ◽  
Shuliang Jiao
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescence Microscopy ◽  
Multimodal Imaging ◽  
Imaging System ◽  
Optical Resolution ◽  
Biological Tissues ◽  
Large Field ◽  
Optical Coherence ◽  
Photoacoustic Microscopy

We have developed a multimodal imaging system, which integrated optical resolution photoacoustic microscopy, optical coherence tomography, optical coherence tomography angiography, and confocal fluorescence microscopy in one platform. The system is able to image complementary features of a biological sample by combining different contrast mechanisms. We achieved fast imaging and large field of view by combining optical scanning with mechanical scanning, similar to our previous publication. We have demonstrated the capability of the multimodal imaging system by imaging a mouse ear in vivo. Impact statement Photoacoustic microscopy-based multimodal imaging technology can provide high-resolution complementary information for biological tissues in vivo. It will potentially bring significant impact on the research and diagnosis of diseases by providing combined structural and functional information.

Gold Nanorod Enhanced Photoacoustic Microscopy and Optical Coherence Tomography of Choroidal Neovascularization

2021 ◽  
Vol 13 (34) ◽  
pp. 40214-40228
Author(s):  
Van-Phuc Nguyen ◽  
Yanxiu Li ◽  
Jessica Henry ◽  
Wei Zhang ◽  
Xueding Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Neovascularization ◽  
Gold Nanorod ◽  
Optical Coherence ◽  
Photoacoustic Microscopy
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