oxidized hdl
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2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Takahiro Kameda ◽  
Yuna Horiuchi ◽  
Shitsuko Shimano ◽  
Kouji Yano ◽  
Shao-Jui Lai ◽  
...  

Abstract Endothelial cell (EC) migration is essential for healing vascular injuries. Previous studies suggest that high-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), the major protein constituent of HDL, have endothelial healing functions. In cardiovascular disease, HDL is modified by myeloperoxidase (MPO) and N-homocysteine, resulting in apoA-I/apoA-II heterodimer and N-homocysteinylated (N-Hcy) apoA-I formation. This study investigated whether these modifications attenuate HDL-mediated endothelial healing. Wound healing assays were performed to analyze the effect of MPO-oxidized HDL and N-Hcy HDL in vitro. HDL obtained from patients with varying troponin I levels were also examined. MPO-oxidized HDL reduces EC migration compared to normal HDL in vitro, and N-Hcy HDL showed a decreasing trend toward EC migration. EC migration after treatment with HDL from patients was decreased compared to HDL isolated from healthy controls. Increased apoA-I/apoA-II heterodimer and N-Hcy apoA-I levels were also detected in HDL from patients. Wound healing cell migration was significantly negatively correlated with the ratio of apoA-I/apoA-II heterodimer to total apoA-II and N-Hcy apoA-I to total apoA-I. MPO-oxidized HDL containing apoA-I/apoA-II heterodimers had a weaker endothelial healing function than did normal HDL. These results indicate that MPO-oxidized HDL and N-Hcy HDL play a key role in the pathogenesis of cardiovascular disease.


Obesity ◽  
2018 ◽  
Vol 27 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Stephen J. Peterson ◽  
Joseph I. Shapiro ◽  
Ellen Thompson ◽  
Shailendra Singh ◽  
Lu Liu ◽  
...  

Biochimie ◽  
2018 ◽  
Vol 153 ◽  
pp. 232-237 ◽  
Author(s):  
Yinan Chen ◽  
Maud Arnal-Levron ◽  
Françoise Hullin-Matsuda ◽  
Carole Knibbe ◽  
Philippe Moulin ◽  
...  

Redox Biology ◽  
2018 ◽  
Vol 15 ◽  
pp. 228-242 ◽  
Author(s):  
Dan He ◽  
Mingming Zhao ◽  
Congying Wu ◽  
Wenjing Zhang ◽  
Chenguang Niu ◽  
...  

2017 ◽  
Vol 45 (2) ◽  
pp. 200-205 ◽  
Author(s):  
Shigeyuki Ebara ◽  
Mikio Marumo ◽  
Jun Mukai ◽  
Makoto Ohki ◽  
Kagehiro Uchida ◽  
...  

2017 ◽  
Vol 155 ◽  
pp. 12-15 ◽  
Author(s):  
Shigeyuki Ebara ◽  
Mikio Marumo ◽  
Chika Yamabata ◽  
Ikumi Nishibe ◽  
Jun-ichi Soneda ◽  
...  

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