Age-related susceptibility to muscle damage following mechanotherapy in rats recovering from disuse atrophy

The inability to fully recover lost muscle mass following periods of disuse atrophy predisposes older adults to lost independence and poor quality of life. We have previously shown that mechanotherapy at a moderate load (4.5 N) enhances muscle mass recovery following atrophy in adult, but not older adult rats. We propose that elevated transverse stiffness in aged muscle inhibits the growth response to mechanotherapy and hypothesize that a higher load (7.6 N) will overcome this resistance to mechanical stimuli. F344/BN adult and older adult male rats underwent 14-days of hindlimb suspension, followed by 7-days of recovery with (RE+M) or without (RE) mechanotherapy at 7.6 N on gastrocnemius muscle. The 7.6 N load was determined by measuring transverse passive stiffness and linearly scaling up from 4.5 N. No differences in protein turnover or mean fiber cross sectional area were observed between RE and RE+M for older adult rats or adult rats at 7.6 N. However, there was a higher number of small muscle fibers present in older adult, but not adult rats, which was explained by a 16-fold increase in the frequency of small fibers expressing embryonic myosin heavy chain. Elevated central nucleation, satellite cell abundance, and dystrophin -/laminin + fibers were present in older adult rats only following 7.6 N, while 4.5 N did not induce damage at either age. We conclude that age is an important variable when considering load used during mechanotherapy and age-related transverse stiffness may predispose older adults to damage during the recovery period following disuse atrophy.

Contribution to the analysis of the frame stiffness of the cranes with loading-unloading trolley

The paper analyzes the dependence of the stiffness of the support frames of the cranes with loading-unloading trolley on the change of geometrical parameters of the frames. The calculation model of the frames with transverse stiffness was formed because it additionally stiffens the supporting surface of the frames for connection with the axial-radial bearing. The relations of characteristic geometrical sizes of longitudinal and transverse elements were established, at which the necessary stiffness of the frames of loading-unloading trolley was achieved. Also, the variables and constants of geometric size were introduced, as well as the constant values of appropriate coefficients, the variation of which provides the possibility to form the optimal structure of the frames of loading-unloading trolley.

Structural Behavior of Digitally Fabricated Thin-Walled Timber Columns

This paper aims to investigate the structural behavior of digitally fabricated thin-walled timber sections with edge connectivity provided by integral mechanical press-fit joints. Experimental, numerical, and analytical investigations have been developed to accurately characterize the press-fit section behavior and their failure modes. Plywood fiber orientation, material thickness, and connection tightness are considered as potential factors that may affect the performance of the press-fit jointing system. Experimental testing of square hollow sections (SHSs) under uniaxial compressive loading showed failure of sections through both conventional crushing and novel pop-off bifurcation failures. Pop-off buckling behaviors were shown to be governed by the integral joint transverse stiffness and its magnitude relative to a critical edge stiffness value. Columns with joint transverse stiffness value less than the critical edge stiffness value exhibited pop-off failures. These joint stiffness values were obtained from testing of unloaded joints and were used to obtain accurate predictions of column failure modes. Joint stiffness values for loaded joints were then predicted with an interpolation model mapping axial strain to a tighter connection tolerance and these were used to obtain accurate estimations for column failure load in most of the tested column types. Comparative investigations showed thin-walled sections with integral joints only to be capable of matching the compressive capacities of glued sections, for instances where crushing governed. Similarly, the weight-specific compressive capacity of timber sections was found to be comparable to thin-walled steel sections when crushing governs.

Influence of fasteners and connections flexibility on deflections of steel building including the stressed skin effect

The paper presents the analysis of the influence of fasteners and connections flexibility on displacements of symmetrical single-bay pitched-roof steel building, including trapezoidal cladding acting as a diaphragm. The purpose of the article was to compare numerical models with and without taking into consideration fasteners and connections flexibility in order to observe the differences in transverse stiffness of the building during modifying model from the simple one to more complex and precise. The analyses were carried out for the 3D structure. Fasteners and connections were substituted by equivalent beam finite elements. Corrugated sheets were replaced by three types of equivalent orthotropic shell models and the influence of the choice of the model on the stiffness of the building was observed. The results showed that in the analysed structure the flexibility of fasteners and connections has negligible effect on transverse displacements of the building in the case of four sides fastening of the sheeting, however in the case of two sides fastening the influence significantly increases.