transgenic lettuce
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Author(s):  
Takashi HAMABATA ◽  
Toshio SATO ◽  
Eiji TAKITA ◽  
Takeshi MATSUI ◽  
Takahiro KAWABATA ◽  
...  

BioTechniques ◽  
2020 ◽  
Vol 68 (4) ◽  
pp. 214-218 ◽  
Author(s):  
Tayebeh Kakeshpour ◽  
Tej Man Tamang ◽  
Woojun D Park ◽  
Murli Manohar ◽  
Jian Yang ◽  
...  

Artificial miRNA technology enables the generation of siRNAs to regulate the expression of targeted genes. However, the application of siRNAs to alter gene expression is challenging due to their instability and requires a means to efficiently deliver siRNAs into the host. Here, we report that the siRNAs targeted to animal mRNAs can be heterologously expressed and stably produced in lettuce. We have modified rice miRNA precursors to produce siRNAs in lettuce with the potential to target mRNAs of mouse complement 3 ( C3) and coagulation factor 7 ( CF7). Expression of primary and mature siRNAs in the transgenic lettuce lines was confirmed via Sanger sequencing. Our study demonstrates an applicable tool to alter gene expression in the targeted host and has potential utility in siRNA-based oral therapeutics.


2019 ◽  
Vol 90 (11) ◽  
pp. 1460-1467 ◽  
Author(s):  
Takashi Hamabata ◽  
Toshio Sato ◽  
Eiji Takita ◽  
Takeshi Matsui ◽  
Taishi Imaoka ◽  
...  

2018 ◽  
Vol 283 ◽  
pp. 62-69 ◽  
Author(s):  
Flavia S. Darqui ◽  
Laura M. Radonic ◽  
Paulina M. Trotz ◽  
Nilda López ◽  
Cecilia Vázquez Rovere ◽  
...  

2017 ◽  
Vol 51 (1) ◽  
pp. 1-7
Author(s):  
I. M. Gerasymenko ◽  
V. V. Kleschevnikov ◽  
V. R. Kedlian ◽  
L. O. Sakhno ◽  
I. A. Arbuzova ◽  
...  
Keyword(s):  

2016 ◽  
Vol 36 (1) ◽  
pp. 49-60 ◽  
Author(s):  
Tomasz Pniewski ◽  
Marcin Czyż ◽  
Katarzyna Wyrwa ◽  
Piotr Bociąg ◽  
Paweł Krajewski ◽  
...  

2016 ◽  
Vol 25 (5) ◽  
pp. 711-719 ◽  
Author(s):  
Yoichi Kawazu ◽  
Ryoi Fujiyama ◽  
Shunsuke Imanishi ◽  
Hiroyuki Fukuoka ◽  
Hirotaka Yamaguchi ◽  
...  

2014 ◽  
Vol 52 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Ken-ichi OKAMURA ◽  
Yoshie MATSUDA ◽  
Kadunari IGARI ◽  
Hirokazu FUKUDA ◽  
Haruhiko MURASE

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