Regulation of Conjugate Rigid Plane Structure to Achieving Transformation of Fluorescent Recognition Properties

Bisbenzimidazole is an important class of fluorescence molecular probe materials with environmental, clinical and biological systems. Meanwhile, different bisbenzimidazole derivatives due to excellent coordination property and various fluorescence characteristic, were...

Organoboron Compounds: Effective Antibacterial and Antiparasitic Agents

The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences. The use of boron-containing compounds as pharmaceutical agents has a long history, and recent developments have produced encouraging strides. Boron agents have been used for both radiotherapy and chemotherapy. In radiotherapy, boron neutron capture therapy (BNCT) has been investigated to treat various types of tumors, such as glioblastoma multiforme (GBM) of brain, head and neck tumors, etc. Boron agents playing essential roles in such treatments and other well-established areas have been discussed elsewhere. Organoboron compounds used to treat various diseases besides tumor treatments through BNCT technology have also marked an important milestone. Following the clinical introduction of bortezomib as an anti-cancer agent, benzoxaborole drugs, tavaborole and crisaborole, have been approved for clinical use in the treatments of onychomycosis and atopic dermatitis. Some heterocyclic organoboron compounds represent potentially promising candidates for anti-infective drugs. This review highlights the clinical applications and perspectives of organoboron compounds with the natural boron atoms in disease treatments without neutron irradiation. The main topic focuses on the therapeutic applications of organoboron compounds in the diseases of tuberculosis and antifungal activity, malaria, neglected tropical diseases and cryptosporidiosis and toxoplasmosis.

Monochromophoric iridium(iii) pyridyl–tetrazine complexes as a unique design strategy for bioorthogonal probes with luminogenic behavior

This is the first reported use of the metal-coordination property of tetrazine in the construction of luminogenic bioorthogonal probes and modulation of the inverse electron-demand Diels–Alder reaction kinetics.

Structures of protonated hydrogen sulfide clusters, H+(H2S)n, highlighting the nature of sulfur-centered intermolecular interactions

Though H2S has the same hydrogen bond coordination property as H2O, intermolecular structures of H+(H2S)n are very different from those of H+(H2O)n, indicating the competition among hydrogen bond and other intermolecular interactions.

ANTI-COORDINATION GAMES AND DYNAMIC STABILITY

We introduce the class of anti-coordination games. A symmetric two-player game is said to have the anti-coordination property if, for any mixed strategy, any worst response to the mixed strategy is in the support of the mixed strategy. Every anti-coordination game has a unique symmetric Nash equilibrium, which lies in the interior of the set of mixed strategies. We investigate the dynamic stability of the equilibrium in a one-population setting. Specifically we focus on the best response dynamic (BRD), where agents in a large population take myopic best responses, and the perfect foresight dynamic (PFD), where agents maximize total discounted payoffs from the present to the future. For any anti-coordination game we show (i) that, for any initial distribution, BRD has a unique solution, which reaches the equilibrium in a finite time, (ii) that the same path is one of the solutions to PFD, and (iii) that no path escapes from the equilibrium in PFD once the path reaches the equilibrium. Moreover we show (iv) that, in some subclasses of anti-coordination games, for any initial state, any solution to PFD converges to the equilibrium. All the results for PFD hold for any discount rate.

Molecular Design, Synthesis and Luminescent Properties of Erbium(III)-Cored Supramolecular Complexes Based on Metalloporphyrins for Optical Amplification

We have investigated the development of erbium(III)-cored supramolecular complexes containing metalloporphyrins to circumvent the solubility problem and improve the optical amplification property. The new synthetic methodology was accomplished through the ligand-exchange model reaction using ErCl3 to optimize its synthetic condition We have designed and synthesized the model complexes to investigate coordination property between the ligand and the erbium ion. Highly coordinated erbium(III)-cored model complexes (at least 8 to 10 coordination) showed the strong near infrared(IR) emission at 1520 nm, corresponding to the 4I13/2 → 4I15/2 transition. Also, with these synthetic results, erbium(III)-cored supramolecular complexes based on metalloporphyrins were synthesized and characterized. They also showed the infrared emission of the 4I13/2 → 4I15/2 transition at 1520 nm.