mendelian sampling
Recently Published Documents


TOTAL DOCUMENTS

11
(FIVE YEARS 1)

H-INDEX

5
(FIVE YEARS 0)

2021 ◽  
Vol 53 (1) ◽  
Author(s):  
Hakimeh Emamgholi Begli ◽  
Lawrence R. Schaeffer ◽  
Emhimad Abdalla ◽  
Emmanuel A. Lozada-Soto ◽  
Alexandra Harlander-Matauschek ◽  
...  

Abstract Background Egg production traits are economically important in poultry breeding programs. Previous studies have shown that incorporating genomic data can increase the accuracy of genetic prediction of egg production. Our objective was to estimate the genetic and phenotypic parameters of such traits and compare the prediction accuracy of pedigree-based random regression best linear unbiased prediction (RR-PBLUP) and genomic single-step random regression BLUP (RR-ssGBLUP). Egg production was recorded on 7422 birds during 24 consecutive weeks from first egg laid. Hatch-week of birth by week of lay and week of lay by age at first egg were fitted as fixed effects and body weight as a covariate, while additive genetic and permanent environment effects were fitted as random effects, along with heterogeneous residual variances over 24 weeks of egg production. Predictions accuracies were compared based on two statistics: (1) the correlation between estimated breeding values and phenotypes divided by the square root of the trait heritability, and (2) the ratio of the variance of BLUP predictions of individual Mendelian sampling effects divided by one half of the estimate of the additive genetic variance. Results Heritability estimates along the production trajectory obtained with RR-PBLUP ranged from 0.09 to 0.22, with higher estimates for intermediate weeks. Estimates of phenotypic correlations between weekly egg production were lower than the corresponding genetic correlation estimates. Our results indicate that genetic correlations decreased over the laying period, with the highest estimate being between traits in later weeks and the lowest between early weeks and later ages. Prediction accuracies based on the correlation-based statistic ranged from 0.11 to 0.44 for RR-PBLUP and from 0.22 to 0.57 for RR-ssGBLUP using the correlation-based statistic. The ratios of the variances of BLUP predictions of Mendelian sampling effects and one half of the additive genetic variance ranged from 0.17 to 0.26 for RR-PBLUP and from 0.17 to 0.34 for RR-ssGBLUP. Although the improvement in accuracies from RR-ssGBLUP over those from RR-PBLUP was not uniform over time for either statistic, accuracies obtained with RR-ssGBLUP were generally equal to or higher than those with RR-PBLUP. Conclusions Our findings show the potential advantage of incorporating genomic data in genetic evaluation of egg production traits using random regression models, which can contribute to the genetic improvement of egg production in turkey populations.


2020 ◽  
Vol 11 ◽  
Author(s):  
Christian R. Werner ◽  
R. Chris Gaynor ◽  
Gregor Gorjanc ◽  
John M. Hickey ◽  
Tobias Kox ◽  
...  

Over the last two decades, the application of genomic selection has been extensively studied in various crop species, and it has become a common practice to report prediction accuracies using cross validation. However, genomic prediction accuracies obtained from random cross validation can be strongly inflated due to population or family structure, a characteristic shared by many breeding populations. An understanding of the effect of population and family structure on prediction accuracy is essential for the successful application of genomic selection in plant breeding programs. The objective of this study was to make this effect and its implications for practical breeding programs comprehensible for breeders and scientists with a limited background in quantitative genetics and genomic selection theory. We, therefore, compared genomic prediction accuracies obtained from different random cross validation approaches and within-family prediction in three different prediction scenarios. We used a highly structured population of 940 Brassica napus hybrids coming from 46 testcross families and two subpopulations. Our demonstrations show how genomic prediction accuracies obtained from among-family predictions in random cross validation and within-family predictions capture different measures of prediction accuracy. While among-family prediction accuracy measures prediction accuracy of both the parent average component and the Mendelian sampling term, within-family prediction only measures how accurately the Mendelian sampling term can be predicted. With this paper we aim to foster a critical approach to different measures of genomic prediction accuracy and a careful analysis of values observed in genomic selection experiments and reported in literature.


2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 51-52
Author(s):  
Ashley Ling ◽  
Samuel E Aggrey ◽  
Romdhane Rekaya

Abstract Superiority of genomic selection (GS) is argued to be due to better modeling of the Mendelian sampling (MS) and tracking of QTL similarities between individuals. It is not clear that a better genome-wide modeling of MS contributes to the increased accuracy. In fact, it might be that modeling of MS outside areas of the genome under selection pressure is detrimental to the accuracy of GS. If true, this hypothesis will provide a better framework to understand the complex relationships between MS, QTL similarity and accuracy. Increases in marker density and the need for marker prioritization makes this hypothesis even more practically important. Answering this question could have a significant impact on accuracy and the computational costs of GS implementation. A 30-chromosome genome with 50K SNPs was simulated. 200 QTL were simulated on two chromosomes for a trait with heritability of 0.4. Genomic relationships were calculated based on all 50K SNPs (G30), 3,333 SNPs on the two chromosomes carrying QTL (G2), and 46,667 SNPs on chromosomes without QTL (G28). Table 1 shows accuracies after 3 and 10 generations of (G)EBV-based selection (M1) and random selection (M2). BLUP accuracies are consistently higher (11.5 to 43.8%) than G28, showing that expected relationships better model QTL similarities than a dense panel of markers that lie outside QTL regions. Inclusion of markers that lie outside QTL regions with markers inside QTL regions reduces accuracies, as shown by the inferior (20.2 to 22.8%) performance of G30 compared to G2. Coefficients of variation were higher for low than high additive relationships suggesting that errors made in estimating QTL similarities for lowly related animals may have the most detrimental impact. Furthermore, while G28 markers capture more variation than pedigree, the superiority of BLUP indicates that variation captured by G28 is not consistent with true variation in QTL inheritance.


2018 ◽  
Vol 101 (3) ◽  
pp. 2187-2198 ◽  
Author(s):  
A.-M. Tyrisevä ◽  
W.F. Fikse ◽  
E.A. Mäntysaari ◽  
J. Jakobsen ◽  
G.P. Aamand ◽  
...  

2016 ◽  
Vol 48 (1) ◽  
Author(s):  
Sarah Bonk ◽  
Manuela Reichelt ◽  
Friedrich Teuscher ◽  
Dierck Segelke ◽  
Norbert Reinsch
Keyword(s):  

2011 ◽  
Vol 93 (1) ◽  
pp. 47-64 ◽  
Author(s):  
W.G. HILL ◽  
B.S. WEIR

SummaryAlthough the expected relationship or proportion of genome shared by pairs of relatives can be obtained from their pedigrees, the actual quantities deviate as a consequence of Mendelian sampling and depend on the number of chromosomes and map length. Formulae have been published previously for the variance of actual relationship for a number of specific types of relatives but no general formula for non-inbred individuals is available. We provide here a unified framework that enables the variances for distant relatives to be easily computed, showing, for example, how the variance of sharing for great grandparent–great grandchild, great uncle–great nephew, half uncle–nephew and first cousins differ, even though they have the same expected relationship. Results are extended in order to include differences in map length between sexes, no recombination in males and sex linkage. We derive the magnitude of skew in the proportion shared, showing the skew becomes increasingly large the more distant the relationship. The results obtained for variation in actual relationship apply directly to the variation in actual inbreeding as both are functions of genomic coancestry, and we show how to partition the variation in actual inbreeding between and within families. Although the variance of actual relationship falls as individuals become more distant, its coefficient of variation rises, and so, exacerbated by the skewness, it becomes increasingly difficult to distinguish different pedigree relationships from the actual fraction of the genome shared.


2005 ◽  
Vol 122 (5) ◽  
pp. 302-308 ◽  
Author(s):  
S. Avendano ◽  
J.A. Woolliams ◽  
B. Villanueva
Keyword(s):  

2004 ◽  
Vol 83 (1) ◽  
pp. 55-64 ◽  
Author(s):  
S. AVENDAÑO ◽  
J. A. WOOLLIAMS ◽  
B. VILLANUEVA

Quadratic indices are a general approach for the joint management of genetic gain and inbreeding in artificial selection programmes. They provide the optimal contributions that selection candidates should have to obtain the maximum gain when the rate of inbreeding is constrained to a predefined value. This study shows that, when using quadratic indices, the selective advantage is a function of the Mendelian sampling terms. That is, at all times, contributions of selected candidates are allocated according to the best available information about their Mendelian sampling terms (i.e. about their superiority over their parental average) and not on their breeding values. By contrast, under standard truncation selection, both estimated breeding values and Mendelian sampling terms play a major role in determining contributions. A measure of the effectiveness of using genetic variation to achieve genetic gain is presented and benchmark values of 0·92 for quadratic optimisation and 0·5 for truncation selection are found for a rate of inbreeding of 0·01 and a heritability of 0·25.


Sign in / Sign up

Export Citation Format

Share Document