surgical sealants
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2020 ◽  
Vol 30 (5) ◽  
pp. 715-723
Author(s):  
Desiree Wussler ◽  
Selina Kiefer ◽  
Susanne Naumann ◽  
Danilo Hackner ◽  
Jonathan Nadjiri ◽  
...  

Abstract OBJECTIVES Existing surgical sealants fail to combine design requirements, such as sealing performance, on-demand activation and biocompatibility. The aim of this study was to compare the effectiveness and safety of the SETALIUM™ Vascular Sealant (SVS), a novel, on-demand activatable sealant, with the commercial sealant, BioGlue®, for the repair of vascular defects. METHODS In an in vivo porcine model, the use of SVS was compared with BioGlue, for sealing 2-mm defects of the carotid artery and jugular vein. Animals were followed for 7 days and 5 weeks (each time point and per experimental group, n = 4), respectively. The degree of stenosis and flow velocity was determined, and the local tissue response was evaluated. RESULTS In vivo incision closure succeeded in all cases, and SVS was superior in clinical usability, enabled by its on-demand activation. Unlike BioGlue, SVS use did not induce stenosis and was associated with physiological blood flow in all cases. Moreover, closure with SVS was associated with a low inflammatory reaction and no thrombus formation or intima proliferation, in contrast to BioGlue. CONCLUSIONS SVS demonstrated effective and rapid sealing of 2-mm vascular defects, with favourable biocompatibility compared to BioGlue. Thus, SVS seems to be an effective and safe vascular sealant.


2020 ◽  
Vol 34 (9) ◽  
pp. 1330-1340 ◽  
Author(s):  
Paul Slezak ◽  
Andrea Klang ◽  
James Ferguson ◽  
Xavier Monforte ◽  
Peter Schmidt ◽  
...  

2019 ◽  
Vol 11 (7) ◽  
pp. 2705-2714 ◽  
Author(s):  
Henri Gondé ◽  
Constance Le Gac ◽  
André Gillibert ◽  
Benjamin Bottet ◽  
Marc Laurent ◽  
...  

2019 ◽  
Vol 157 (1) ◽  
pp. 176-183 ◽  
Author(s):  
Mark H. Murdock ◽  
Jordan T. Chang ◽  
Samuel K. Luketich ◽  
Drake Pedersen ◽  
George S. Hussey ◽  
...  

2017 ◽  
Vol 9 (410) ◽  
pp. eaai7466 ◽  
Author(s):  
Nasim Annabi ◽  
Yi-Nan Zhang ◽  
Alexander Assmann ◽  
Ehsan Shirzaei Sani ◽  
George Cheng ◽  
...  

Surgical sealants have been used for sealing or reconnecting ruptured tissues but often have low adhesion, inappropriate mechanical strength, cytotoxicity concerns, and poor performance in biological environments. To address these challenges, we engineered a biocompatible and highly elastic hydrogel sealant with tunable adhesion properties by photocrosslinking the recombinant human protein tropoelastin. The subcutaneous implantation of the methacryloyl-substituted tropoelastin (MeTro) sealant in rodents demonstrated low toxicity and controlled degradation. All animals survived surgical procedures with adequate blood circulation by using MeTro in an incisional model of artery sealing in rats, and animals showed normal breathing and lung function in a model of surgically induced rat lung leakage. In vivo experiments in a porcine model demonstrated complete sealing of severely leaking lung tissue in the absence of sutures or staples, with no clinical or sonographic signs of pneumothorax during 14 days of follow-up. The engineered MeTro sealant has high potential for clinical applications because of superior adhesion and mechanical properties compared to commercially available sealants, as well as opportunity for further optimization of the degradation rate to fit desired surgical applications on different tissues.


2016 ◽  
Vol 103 (13) ◽  
pp. 1758-1767 ◽  
Author(s):  
A. C. Rogers ◽  
L. P. Turley ◽  
K. S. Cross ◽  
M. P. McMonagle

2016 ◽  
Vol 70 ◽  
pp. 81-89 ◽  
Author(s):  
Bertrand R.M. Perrin ◽  
Muriel Braccini ◽  
Cécile M. Bidan ◽  
Christophe Derail ◽  
Eric Papon ◽  
...  

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