Enhanced Sealing by Hydrophobic Modification of Alaska Pollock-Derived Gelatin-Based Surgical Sealants for the Treatment of Pulmonary Air Leaks

2016 ◽  
Vol 17 (4) ◽  
pp. 1600349 ◽  
Author(s):  
Ryo Mizuta ◽  
Tetsushi Taguchi
Keyword(s):  
Hydrophobic Modification ◽  
Air Leaks ◽  
Surgical Sealants

In Vitro Lung Model Assessing the Efficacy of Surgical Sealants in Treating Alveolar Air Leaks

2015 ◽  
Vol 28 (6) ◽  
pp. 323-327 ◽  
Author(s):  
Ruoyu Zhang ◽  
Maximilian Bures ◽  
Hans-Klaus Höffler ◽  
Danny Jonigk ◽  
Axel Haverich ◽  
...  
Keyword(s):  
Lung Model ◽  
Alveolar Air ◽  
Air Leaks ◽  
Surgical Sealants

scholarly journals Bio-artificial pleura using autologous dermal fibroblast sheets to mitigate air leaks during thoracoscopic lung resection

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Masato Kanzaki ◽  
Ryo Takagi ◽  
Kaoru Washio ◽  
Mami Kokubo ◽  
Shota Mitsuboshi ◽  
...  
Keyword(s):  
Dermal Fibroblast ◽  
Lung Resection ◽  
Fibroblast Cell ◽  
Patient Specific ◽  
Cell Content ◽  
Cell Monolayers ◽  
Air Leaks ◽  
Skin Biopsies ◽  
Dermal Cells ◽  
Lung Resections

AbstractLung air leaks (LALs) due to visceral pleura injury during surgery are a difficult-to-avoid complication in thoracic surgery (TS). Reliable LAL closure is an important patient management issue after TS. We demonstrated both safeties of transplantation of a cultured human autologous dermal fibroblast sheet (DFS) to LALs. From May 2016 to March 2018, five patients who underwent thoracoscopic lung resection met all the inclusion criteria. Skin biopsies were acquired from each patient to source autologous dermal cells for DFS fabrication. During the primary culture, fibroblasts migrated from the dermal tissue pieces and proliferated to form cell monolayers. These fibroblasts were subcultured to confluence. Transplantable DFSs were fabricated from these subcultured fibroblasts that were trypsinized and seeded onto temperature-responsive culture dishes. After 10 days of fabrication culture, intact patient-specific DFS were harvested. DFSs were analyzed for fibroblast cell content and tissue contaminants prior to application. For closing intraoperative LAL, mean number of transplanted autologous DFS per patient was 6 ± 2 sheets. Mean chest drainage duration was 5.0 ± 4.8 days. The two patients with major LAL had a drainage duration of more than 7 days. All patients currently have no LAL recurrence after discharge. DFSs effectively maintain LAL closure via remodeling of the deposited extracellular matrix. The use of autologous DFSs to permanently close air leaks using a patient-derived source is expected to reduce surgical complications during high-risk lung resections.

Hydrophobic modification of fir wood surface via low ppm ATRP strategy

Polymer ◽  
2021 ◽  
pp. 123942
Author(s):  
I. Zaborniak ◽  
A. Macior ◽  
P. Chmielarz ◽  
J. Smenda ◽  
K. Wolski
Keyword(s):  
Wood Surface ◽  
Hydrophobic Modification

An efficient hydrophobic modification of TS-1 and its application in the epoxidation of propylene

2019 ◽  
Vol 43 (26) ◽  
pp. 10390-10397 ◽  
Author(s):  
Baohe Wang ◽  
Huanhuan Han ◽  
Baomin Ge ◽  
Jing Ma ◽  
Jing Zhu ◽  
...  
Keyword(s):  
Hydrophobic Modification ◽  
Epoxidation Of Propylene ◽  
Product Generation ◽  
Precursor Modification

Hydrophobic TS-1 was synthesized through resole resin precursor modification. Hydrophobic TS-1 can avoid by-product generation.

Management of Persistent Air Leaks with Intrabronchial Valves

2017 ◽  
Vol 66 (07) ◽  
pp. 603-606
Author(s):  
Andreas Hecker ◽  
Konstantin Mayer ◽  
Biruta Witte ◽  
Matthias Hecker
Keyword(s):  
Thoracic Surgery ◽  
Minimal Invasive ◽  
Therapeutic Approaches ◽  
Air Leak ◽  
Frequent Complication ◽  
Less Invasive ◽  
Air Leaks ◽  
Prolonged Hospitalization ◽  
Highly Effective ◽  
Endoscopic Placement

AbstractPersistent air leaks (PALs) are regarded as a frequent complication after thoracic surgery resulting in prolonged hospitalization and increased morbidity. Several more or less invasive therapeutic approaches are available for treatment of PAL with varying degrees of success. The endoscopic placement of one-way intrabronchial valves in the segment(s) in which the air leak has been located offers a highly effective and well-tolerated minimal invasive option for patients with PAL.

Super-hydrophobic modification of porous natural polymer “luffa sponge” for oil absorption

Polymer ◽  
2017 ◽  
Vol 126 ◽  
pp. 470-476 ◽  
Author(s):  
Zhe Wang ◽  
Hongyang Ma ◽  
Benjamin Chu ◽  
Benjamin S. Hsiao
Keyword(s):  
Oil Absorption ◽  
Natural Polymer ◽  
Hydrophobic Modification ◽  
Luffa Sponge

scholarly journals Intrabronchial Valve Treatment for Prolonged Air Leak: Can We Justify the Cost?

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Eitan Podgaetz ◽  
Felix Zamora ◽  
Heidi Gibson ◽  
Rafael S. Andrade ◽  
Eric Hall ◽  
...  
Keyword(s):  
Individual Patient Data ◽  
Cost Effective ◽  
Air Leak ◽  
Levels Of Care ◽  
Air Leaks ◽  
Limited Experience ◽  
Tube Removal ◽  
Prolonged Air Leak ◽  
Chest Tube Removal ◽  
The Cost

Background.Prolonged air leak is defined as an ongoing air leak for more than 5 days. Intrabronchial valve (IBV) treatment is approved for the treatment of air leaks.Objective.To analyze our experience with IBV and valuate its cost-effectiveness.Methods.Retrospective analysis of IBV from June 2013 to October 2014. We analyzed direct costs based on hospital and operating room charges. We used average costs in US dollars for the analysis not individual patient data.Results.We treated 13 patients (9 M/4 F), median age of 60 years (38 to 90). Median time from diagnosis to IBV placement was 9.8 days, time from IBV placement to chest tube removal was 3 days, and time from IBV placement to hospital discharge was 4 days. Average room and board costs were $14,605 including all levels of care. IBV cost is $2750 per valve. The average number of valves used was 4. Total cost of procedure, valves, and hospital stay until discharge was $13,900.Conclusion.In our limited experience, the use of IBV to treat prolonged air leaks is safe and appears cost-effective. In pure financial terms, the cost seems justified for any air leak predicted to last greater than 8 days.

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