CONCEPTUAL STUDY OF PUNARNAVASHTAKA KSHEERABASTI IN GARBHINI SHOTHA (EDEMA IN PREGNANCY.)

Pregnancy is most beautiful phase of a women’s life its incredible journey that leads to great emotional fulfillment to women and Having a successful motherhood and continuation of pregnancy till term is very important. Garbhini Shotha (Edema in Gravidarum) is one of the most commonly found in Garbhini (Gravidarum) which mentioned in Garbhopadrava (Complications in pregnancy). There are 8 Upadravas (Complications) are mentioned in Harita Sanhita. On the basis of signs and symptoms Garbhini Shotha correlates with Pregnancy induced Hypertension (PIH) in Modern science. Number of causes have been Proposed but none of them has been proved It May leads to Preeclampsia which is life threatening convulsive disorder. Modern science has treatment on that, but it is not satisfactory it can lead side effects also so that I have tried to explain that Punarnavashtak Ksheerbasti this Ayur- vedic Medicine can overcome this problem by its Shothaghna (removing swelling) and anti-hypertensive Properties. This drug act with their different Properties on basis of causative factors of disease in early stages. Keywords: Garbhini Shotha, Punarnavashtak Ksheerbasti, Punarnavashtaka Kwatha, Edema in pregnancy

GM2-gangliosidosis, type I (Tay – Sachs disease) in the pediatrician practice

Background. GM2-gangliosidosis, type I (Tay-Sachs disease) is rare hereditary disease caused by mutations in the HEXA gene encoding the alpha subunit of lysosomal hexosaminidase A. It leads to accumulation of GM2-ganglioside in lysosomes and cell death. The major clinical signs of this disease are regression of motor and psychoverbal skills, progressive macrocephaly, diffuse muscle hypotension, convulsive disorder. Almost all patients with this disease have the “cherry red spot” symptom on the fundus of the eye.Clinical case description. We show clinical description of the patient with disease manifested with the lesion of visual analyzer. The child was sent for geneticist’s consultation due to revealed ophthalmic picture of the “cherry red spot” symptom on the fundus of the eye. Molecular genetic testing has revealed in the patient c.1274_1278 dupTATC (CI 880091) mutation in homozygous state in HEXA gene.Concllusion. Differential diagnosis of this disease should be performed with other diseases from the group of inherited metabolic diseases associated with early regression of psychomotor skills, progressive vision loss, “cherry red spot” symptom on the fundus of the eye and convulsive disorder

CLINICAL CASE OF WHITE SPIRIT TOXIC ACTION IN A 2-YEAR-OLD CHILD

Purpose. To describe the clinical observation of white spirit toxic effect resulting from an accidental fracture in a 2-year-old child. Materials and methods. Medical card retrospective analysis. Clinical and laboratory data were examined to estimate the functional state of a patient’s basic systems. Results and discussion. The cerebral and respiratory systems were rapidly affected in the acute period. Somatogenic stage of poisoning was complicated by the course of acute respiratory distress syndrome, toxic encephalopathy with a convulsive disorder, intestinal failure, and systemic inflammatory response syndrome. Conclusion. White spirit toxic effect in a child was manifested through long-term cerebral, respiratory and intestinal failure.

Clinical, neuroimaging and eeg correlations in epileptic syndrome in patients with a brain tumor

The results of the survey of 193 neuro-oncological patients with epileptic seizures are showed. The control group consisted of 97 patients with brain tumors without the development of epileptic seizures. It is found that in patients with the development of epileptic seizures as a first symptom of cerebral tumors predominated simple partial seizures. Early seizures occurred more frequently in lesions of the left hemisphere of the brain with the formation of focal abnormal EEG activity in the same hemisphere of the brain. Convulsive disorder prevailed in the localization of intracerebral tumors with caudal direction of its growth.

Afebrile Benign Convulsion Associated With Mild Gastroenteritis

Background: Benign convulsion with mild gastroenteritis is a new clinical entity that occurs in children who are otherwise healthy. Method: This cohort study held among patients with afebrile convulsion and accompanying gastroenteritis in a tertiary children hospital during a 2-year period. Demographic and clinical data were analyzed. Neurodevelopmental milestones were observed during a follow-up period of 12 to 24 months. Results: Twenty-five patients aged 3 to 48 months with female predominance were enrolled. Ninety-three percent of cases experienced generalized tonic-clonic seizures. One-third of seizures occurred in clusters. Primary laboratory findings and electroencephalography were normal except for 3 with few epileptic waves. During the follow-up period, no seizure recurrence happened. Long-term antiepileptic treatment was unnecessary. Conclusion: Afebrile convulsion accompanying mild gastroenteritis is a convulsive disorder with reassuring prognosis. Due to its benign course, comprehensive neurodiagnostic evaluation and long-term antiepileptic drugs are usually avoidable.