end group functionalization
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Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2720
Author(s):  
Anca-Dana Bendrea ◽  
Luminita Cianga ◽  
Gabriela-Liliana Ailiesei ◽  
Elena-Laura Ursu ◽  
Demet Göen Göen Colak ◽  
...  

End-group functionalization of homopolymers is a valuable way to produce high-fidelity nanostructured and functional soft materials when the structures obtained have the capacity for self-assembly (SA) encoded in their structural details. Herein, an end-functionalized PCL with a π-conjugated EDOT moiety, (EDOT-PCL), designed exclusively from hydrophobic domains, as a functional “hydrophobic amphiphile”, was synthesized in the bulk ROP of ε-caprolactone. The experimental results obtained by spectroscopic methods, including NMR, UV-vis, and fluorescence, using DLS and by AFM, confirm that in solvents with extremely different polarities (chloroform and acetonitrile), EDOT-PCL presents an interaction- and structure-based bias, which is strong and selective enough to exert control over supramolecular packing, both in dispersions and in the film state. This leads to the diversity of SA structures, including spheroidal, straight, and helical rods, as well as orthorhombic single crystals, with solvent-dependent shapes and sizes, confirming that EDOT-PCL behaves as a “block-molecule”. According to the results from AFM imaging, an unexpected transformation of micelle-type nanostructures into single 2D lamellar crystals, through breakout crystallization, took place by simple acetonitrile evaporation during the formation of the film on the mica support at room temperature. Moreover, EDOT-PCL’s propensity for spontaneous oxidant-free oligomerization in acidic media was proposed as a presumptive answer for the unexpected appearance of blue color during its dissolution in CDCl3 at a high concentration. FT-IR, UV-vis, and fluorescence techniques were used to support this claim. Besides being intriguing and unforeseen, the experimental findings concerning EDOT-PCL have raised new and interesting questions that deserve to be addressed in future research.


2020 ◽  
Vol 44 (43) ◽  
pp. 18813-18822
Author(s):  
Marie-Hélène Tremblay ◽  
Abdel Al Ahmad ◽  
W. G. Skene

A conjugated azomethine end-capped with phenyl-ureas was prepared by a convergent approach. Hydrogen bonding with the ureas was confirmed and the spectroscopic properties could be enhanced with the supramolecular bonds.


2019 ◽  
Vol 120 ◽  
pp. 109273 ◽  
Author(s):  
Annelore Podevyn ◽  
Koen Arys ◽  
Victor R. de la Rosa ◽  
Mathias Glassner ◽  
Richard Hoogenboom

2018 ◽  
Vol 7 (7) ◽  
pp. 795-800 ◽  
Author(s):  
Jacob A. Hill ◽  
Kevin J. Endres ◽  
John Meyerhofer ◽  
Qiming He ◽  
Chrys Wesdemiotis ◽  
...  

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18628-18638 ◽  
Author(s):  
V. D. Pickenhahn ◽  
M. Grange ◽  
G. De Crescenzo ◽  
M. Lavertu ◽  
M. D. Buschmann

Non-reactive chitosan extremities are regioselectively activated with a trivalent linker, called triskelion, allowing subsequent end-group functionalization with any thiol-reactive species.


MRS Advances ◽  
2017 ◽  
Vol 2 (47) ◽  
pp. 2571-2579 ◽  
Author(s):  
Zewang You ◽  
Marc Behl ◽  
Candy Löwenberg ◽  
Andreas Lendlein

ABSTRACTN-terminal methacrylation of peptide MAX1, which is capable of conformational changes by variation of the pH, results in a peptide, named VK20. Increasing the reactivity of this terminal group enables further coupling reactions or chemical modifications of the peptide. However, this end group functionalization may influence the ability of conformational changes of VK20, as well as its properties. In this paper, the influence of pH on the transition between random coil and ß-sheet conformation of VK20, including the transition kinetics, were investigated. At pH values of 9 and higher, the kinetics of ß-sheet formation increased for VK20, compared to MAX1. The self-assembly into ß-sheets recognized by the formation of a physically crosslinked gel was furthermore indicated by a significant increase of G’. An increase in pH (from 9 to 9.5) led to a faster gelation of the peptide VK20. Simultaneously, G’ was increased from 460 ± 70 Pa (at pH 9) to 1520 ± 180 Pa (at pH 9.5). At the nanoscale, the gel showed a highly interconnected fibrillary network structure with uniform fibril widths of approximately 3.4 ± 0.5 nm (N=30). The recovery of the peptide conformation back to random coil resulted in the dissolution of the gel, whereby the kinetics of the recovery depended on the pH. Conclusively, the ability of MAX1 to undergo conformational changes was not affected by N-terminal methacrylation whereas the kinetics of pH-sensitive ß-sheet formations has been increased.


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