lipid composition of blood plasma high density lipoproteins as marker of metabolic reactions of urgent adaptations under acute stress

The article substantiates the mechanisms and significance of the increased contents of blood plasma cholesterol and high density lipoproteins (HDLP) under acute exposure to stress factors leading to activation of metabolism. To a great extent, these changes reflect the adaptation rearrangements in cell membranes that are predominantly haracterized by a decreased content of free cholesterol in their composition due to its efflux to HDLP particles . The changes in HDLP fatty acid composition also contribute to this process resulting in a reduction of membrane microviscosity so that to intensify the intracellular metabolism and to enhance cellular functional activity.

Molecular rotors report on changes in live cell plasma membrane microviscosity upon interaction with beta-amyloid aggregates

Viscosity-sensing fluorophores termed molecular rotors were used to investigate the microviscosity of plasma membranes of live cells upon interaction with oligomeric and fibrillar forms of beta-amyloid Aβ(1–42).