The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model

2016 ◽  
Vol 158 ◽  
pp. 112-120 ◽  
Author(s):  
Jan Vevera ◽  
Karel Valeš ◽  
Zdeněk Fišar ◽  
Jana Hroudová ◽  
Namrata Singh ◽  
...  
Keyword(s):  
Animal Model ◽  
Behavioral Changes ◽  
Serotonin Uptake ◽  
Membrane Microviscosity

Effect of Serotonin-1A receptor on behavioral changes in animal model of schizophrenia-like behavior

2008 ◽  
Vol 23 ◽  
pp. S61
Author(s):  
V. Bubenikova-Valesova ◽  
M. Votava ◽  
T. Palenicek ◽  
J. Horacek ◽  
C. Hoschl
Keyword(s):  
Animal Model ◽  
Behavioral Changes ◽  
Serotonin 1A Receptor

Nigral But Not Striatal Grafts the Subthalamic Nuceus Produce Behavioral Changes in an Animal Model of Parkinson's Disease

Neurosurgery ◽  
1997 ◽  
Vol 41 (3) ◽  
pp. 723-724
Author(s):  
Craig van Horne ◽  
Servet Eken ◽  
Barry Hoffer ◽  
Anne-Charlotte Granholm
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Behavioral Changes ◽  
Striatal Grafts

scholarly journals Sertraline Induces Toxicity and Behavioral Alterations in Planarians

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Isabela Salvador Thumé ◽  
Marcos Emílio Frizzo
Keyword(s):  
Animal Model ◽  
Tissue Damage ◽  
Cell Types ◽  
Behavioral Changes ◽  
Locomotory Activity ◽  
Behavioral Alterations ◽  
Spontaneous Movement ◽  
Rapid Reduction ◽  
Different Cell Types

Toxicity attributed to sertraline has been demonstrated recently in different cell types and also in some organisms. We investigated the effect of sertraline on planarians, which are considered suitable for investigations in neurotoxicology and currently are widely used as an animal model in neuropharmacological studies. Planarians treated with 10 µM sertraline showed a rapid reduction in their spontaneous movement until they became completely motionless and then showed a series of asynchronous paroxysms (seizures) followed by progressive tissue damage, beginning 48 h after the sertraline treatment, and died approximately 72 h later. Our data showed that sertraline does not cause planarian death within the range of therapeutic concentrations; however, behavioral alterations were observed with concentrations that can be considered compatible with therapeutic ones, such as a significant reduction in planarian locomotory activity at 0.4 µM. Treatment with 4 µM sertraline had a significant effect, reducing planarian locomotory activity and increasing the number of asynchronous paroxysms; both effects were significantly maintained even 24 h after the sertraline was withdrawn. These behavioral changes observed at low micromolar concentrations suggest that sertraline might have residual biological consequences for planarians, even after it is withdrawn.

Effect of folic acid on oxidative stress and behavioral changes in the animal model of schizophrenia induced by ketamine

2016 ◽  
Vol 81 ◽  
pp. 23-35 ◽  
Author(s):  
Alexandra I. Zugno ◽  
Lara Canever ◽  
Alexandra S. Heylmann ◽  
Patrícia G. Wessler ◽  
Amanda Steckert ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Folic Acid ◽  
Behavioral Changes

Effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia

2015 ◽  
Vol 281 ◽  
pp. 78-82 ◽  
Author(s):  
Clarissa M. Comim ◽  
Napoleão C. Silva ◽  
Janini J. Patrício ◽  
Daphne Palmas ◽  
Bruna P. Mendonça ◽  
...  
Keyword(s):  
Animal Model ◽  
Behavioral Changes

Animal model of autism induced by prenatal exposure to valproate: Behavioral changes and liver parameters

2011 ◽  
Vol 1408 ◽  
pp. 8-16 ◽  
Author(s):  
Victorio Bambini-Junior ◽  
Leticia Rodrigues ◽  
Guilherme Antônio Behr ◽  
José Cláudio Fonseca Moreira ◽  
Rudimar Riesgo ◽  
...  
Keyword(s):  
Animal Model ◽  
Prenatal Exposure ◽  
Behavioral Changes ◽  
Liver Parameters

Sickness Behavior Score Is Associated with Neuroinflammation and Late Behavioral Changes in Polymicrobial Sepsis Animal Model

Inflammation ◽  
2020 ◽  
Vol 43 (3) ◽  
pp. 1019-1034 ◽  
Author(s):  
Mariana Pereira de Souza Goldim ◽  
Amanda Della Giustina ◽  
Khiany Mathias ◽  
Aloir de Oliveira Junior ◽  
Maria Eduarda Fileti ◽  
...  
Keyword(s):  
Animal Model ◽  
Sickness Behavior ◽  
Behavioral Changes ◽  
Polymicrobial Sepsis
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