CNC Milling of Medical-Grade PMMA

This study evaluates CNC milling parameters (spindle speed, depth of cut, and feed rate) on medical-grade PMMA. A single objective analysis conducted showed that the optimal material removal rate (MRR) occurs at a spindle speed of 1250 rpm, a depth of cut of 1.2 mm, and a feed rate of 350 mm/min. The ANOVA showed that feed rate is the most significant factor towards the MRR, and spindle speed (11.83%) is the least contributing. The optimal surface roughness (Ra) occurred at spindle speed of 500 rpm, depth of cut of 1.2 mm, and feed rate of 200 mm/min. The milling factors were insignificant. A regression analysis for prediction was also conducted. Further, a multi-objective optimization was conducted using the Grey Relational Analysis. It showed that the best trade-off between the MRR and the Ra could be obtained from a combination of 1250 rpm (spindle speed), 1.2 mm (depth of cut), and 350 mm/min (feed rate). The depth of cut was the largest contributor towards the grey relational grade (54.48%), followed by the feed rate (10.36%), and finally, the spindle speed (4.28%).

Protection against the Omicron and Subsequent Coronavirus Variants: Medical-grade Masking, Third Dose Vaccination, Updating Vaccines, and Pursuing Universal Vaccine

The article's abstract is not available.

The Effect of Niobium Addition on Mechanical Properties and Corrosion Resistance of a Medical Grade SS316L

To improve mechanical properties, especially elongation, of as-cast medical grade 316L stainless steel, niobium (Nb) was introduced into the alloys, followed by solution heat treatment. Alloying was performed using a 250 kg air induction melting furnace with duplex raw materials and ferronickel. Heat treatment using a solution at 1040 oC, with a holding time of 45 minutes, and water quenching was used. The sample was tested using hardness and ultimate tensile machines. Corrosion tests with simulated body fluids were carried out using media with similar corrosion conditions to human blood. Microstructure observations were performed optically. The results show that the addition of Nb increases the hardness of medical grade 316L stainless steel by 6% compared to the unalloyed steel, both before and after heat treatment. The addition of Nb increases the tensile strength by 8% compared to non-heat treated steel and increases the elongation before and after heat treatment by 8% and 5%, respectively. However, the corrosion rate of the material with Nb is higher than without the addition of Nb. Nb as a carbide former improves the mechanical properties of medical grade 316L stainless steel but adversely affects its corrosion resistance

Is it possible to use a 100% Medical Grade Honey in the premature babies?

Le proprietà curative del miele sono sempre più affermate nella medicina moderna, soprattutto nel trattamento di lesioni cutanee di varia natura come piaghe da decubito, ustioni e stravaso di farmaci. Esistono diversi studi sull’uso del miele nei pazienti adulti ma non esistono linee guida universali nella popolazione pediatrica e soprattutto in quella neonatale. Presso l’Hevi Pediatric Teaching Hospital di Duhok, Iraq, un prematuro di peso estremamente basso alla nascita, con lesioni al piede da stravaso di farmaco, è stato trattato con il Medical Grade Honey al 100%. Dopo 28 giorni, la lesione è guarita, senza ricorrere alla rimozione chirurgica del tessuto e senza complicazioni allergiche per il paziente. L’uso del miele nei prematuri deve essere ulteriormente studiato e preso in considerazione.

Medical-Grade Honey Outperforms Conventional Treatments for Healing Cold Sores—A Clinical Study

Cold sores are nasolabial blisters caused by herpes simplex virus (HSV) infections. Novel therapies demonstrating simultaneously antiviral activity and improved wound healing are warranted. The aim of this study was to investigate the efficacy of medical-grade honey (MGH) for treating HSV-induced cold sores. A crossover trial was performed in patients with recurrent cold sores (n = 29). The majority (65.6%) of these patients experience four or more episodes per year, thus forming a valid self-control group. In this study, patients applied an MGH-based formulation (L-Mesitran Soft) on their cold sore at the onset of symptoms (62.1%) or appearing of blister (37.9%) and compared it to their conventional treatments. After complete healing, patients filled in a questionnaire evaluating healing, pain, and itching. The average absolute healing time was 72.4% slower with conventional treatment (10.0 days) compared to MGH (5.8 days). After MGH treatment, 86.2% of all patients experienced faster objective healing (6.9% similar and 6.9% slower) and the subjective healing score was higher in 79.3% of the patients (20.7% similar). If the patients normally experience pain and itching during their cold sores, these levels were lower with MGH therapy compared to conventional treatment in 72.7% and 71.4% of the patients, respectively. Moreover, 100% of the patients prefer MGH treatment over conventional treatment and will use it again on future cold sores. MGH is a promising alternative treatment for cold sores, likely by combining both increased antiviral and wound healing activities while alleviating pain and itching.