CLINICAL EFFICACY OF DASHMOOL KWATH NASYA IN THE MANAGEMENT OF MANYASTAMBHA WITH SPECIAL REFERENCE TO CERVICAL SPONDYLITIS

Background: Nasya is an essential therapeutic procedure as many of the courses of Ayurvedic treatment. It comes under the Panchashodhana karmas. It is necessary in all Urdhwa jathru vikaras. Nasya is effective for inducing immediate results and serves as a permanent cure. Cervical spondylotic change is frequently found in many asymptomatic adults, with 25 the age of 40, 50% of adults over the age of 40 and 85% of adults over the age of 60 showing evidence of disc degeneration. Cervical spondylosis can be compared with Manyastambha based on signs & symptoms. Nasya is the simple techniques and ingredients are readily available & economical. Also, these are indicated in the management of Manyastambha and have no proven adverse effects. This study was intended to assess the efficacy of the Dashmool Kwath Nasya in the management of this disease. Method: Randomly, 30 patients of Manyastambha were selected and paired “t” test was used. Result: Statistically significant improvement was found in this study on post-follow-up. Conclusion: Dashmool Kwath Nasya is having a prolonged action as it is having highly significant results post follow up of treatment as compared to after treatment.

Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy

Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme β-glucuronidase that causes the appearance of bladder tumors. The products demonstrated prolonged action and were stable during storage.

Results of application composite hydrogel coatings based on polyvinyl alcohol in the experiment

The results of the use in the experiment of composite hydrogel coatings of prolonged action based on polyvinyl alcohol are investigated.Objective. The aim of the study is a comparative clinical assessment of the effectiveness of the developed composite hydrogel coatings of prolonged action in an experiment in laboratory rats.Materials and research methods. After modeling alloxan diabetes mellitus and neuroischemic form of diabetic foot in laboratory white Wistar rats, the developed wound dressings were applied. A clinical analysis of their effectiveness was carried out and the optimal composition was determined. The animals were divided into three groups, 10 animals in each group, as follows: the first — control with self-healing of the wound, the second — with samples No. 1 (polyvinyl alcohol + chitosan + pectin + L-aspartic acid + gentamicin), the third — with samples No. 2 (polyvinyl alcohol + chitosan + pectin + L-aspartic acid + gentamicin + methyluracil). The first dressing change was carried out on the third day with the taking of histological material, then - every other day. When changing the dressing, such parameters as the nature and amount of wound discharge, the size of the ulcer, the presence of granulations and epithelialization were assessed. Dynamic assessment was performed on the 3rd, 7th, 14th and 21st days. The measurement of the area of the ulcer was carried out by transferring the contour of the ulcer to graph paper with manual counting.Research results. The healing rate of ulcers in the experimental groups was higher than in the control group. When comparing second and third groups, a significant increase in speed was noted by the seventh day in third group (p < 0.05), which reduced the overall healing time of ulcers by 7 days.Conclusion. The study showed that the healing time of ulcers in laboratory animals with the use of the developed wound dressings is significantly reduced in comparison with the control group. The proposed method of local treatment can be considered effective in the treatment of vascular etiology trophic ulcers against the background of diabetes mellitus.

Methodological approaches to the use of images from uavs to assess the technological stress of crops

The article is devoted to the applied aspects of UAV use, namely the monitoring of winter wheat crops in relation to the stresses caused by technological stresses. First of all, this applies to the prolonged action of herbicides left over from the predecessor crop and which cause stress in new crops. The issue has local specifics related to the inconsistency of plant cultivation technologies and to the insufficient study of the impact of the latest plant protection products in domestic soil conditions. Restoration of crop yields is possible with timely identification of the causes of stress, but decision-making time is limited, which requires the introduction of the latest monitoring technologies suitable for industrial scale. In laboratory studies using phytochambers, the presence of both spectral indicators of healthy and affected plants and the difference in their dimensions were recorded. However, such differences can be explained by other stressors, so it was not possible to establish clear criteria for spectral or spectral-spatial monitoring methods that clearly indicated the stress caused by the after-effects of herbicides. In field studies using the Slantrange complex mounted on a DJI Matrice 600 UAV as an object of study, the distribution of stress areas in the field was analyzed. It was found that, in purely spectral and spectral-spatial monitoring of winter wheat, it was not possible to reliably identify the stressful nature caused by the aftereffects of herbicides, ie ground platforms for spectral sensor equipment are ineffective. It is proved that the maps of stress indices obtained on the basis of high-resolution data from UAVs can be considered as a separate object of research on the interpretation of the causes of stress of complex biotechnical objects such as crops. Improving the reliability and reliability of monitoring data can be achieved by implementing systems of machine data processing and computer training to find correlations between the distribution of stress in plants in the field and the implementation of technological operations, terrain. Key words: UAV, stress, prolonged action of herbicides, Slantrange

Applicability of modified carbon sorbent for removing potentially toxic biologically active molecules of aromatic structure from blood plasma

The modification of the mesoporous carbon sorbent with 3-phenylpropanoic acid was carried out in order to create preparations of complex, prolonged action, exhibiting detoxifying, antibacterial, and antifungal properties due to the applied modifier, which is capable of migrating into the solution and exhibiting its own biospecific properties. A technique was developed for fixing 3-phenylpropionic acid (PhPA) on a carbon support by its adsorption from solution. Three types of sorbents with various content of the modifier (PhPA) and the sorbent without modifier were studied. The sorption activity of new sorbents was studied using liquid-liquid extraction and gas chromatography-mass spectrometry methods on model experiments with plasma and aqueous additives of hydroxylated phenyl-containing acids (PhCAs) in various concentrations. The specific surface area was significantly changed for sorbent, modified with 1 × 10−3 mol/L of PhPA solution, and was 25% less than the area of unmodified sorbent. Potentially toxic biologically active hydroxylated PhCAs were used to create model solutions. The degrees of sorption of these compounds were close to 100%, except phenyllactic acid (over 80%). The sorbent without modifier and two sorbents with the lowest content of the modifier are considered to be more effective for the purification of the plasma from the hydroxylated PhCAs than the sorbent with the highest concentration of the modifier. Simultaneous adsorption of toxic metabolites from the bloodstream and desorption of beneficial ones can be used for a more subtle correction of the patient’s condition.

TOXICOLOGICAL CHARACTERISTICS OF A VETERINARY ANTI-PARASITIC PREPARATION WITH A PROLONGED ACTION IN THE FORM OF A SOLUTION FOR INTERNAL ADMISSION

This article presents the results of studies of the toxicological characteristics of a longacting veterinary medicinal product "Neoterica Protecto Syrup" based on moxidectin in the form of an oral solution. Acute oral toxicity was studied in white mice and white rats. As a result, the LD50 of the drug was 4300 mg/kg for male and female mice, 3500 mg/kg for male rats, and 5700 mg/kg for female rats, and on the basis of which it was established that the drug belongs to the 3rd hazard class (moderately hazardous substances) according to GOST 12.1.007-76. Acute cutaneous toxicity was investigated and the irritant effect of the drug on white rats was assessed, for the drug the 4th hazard class (low-hazard substances) was established according to GOST 12.1.007-76. The subchronic toxicity of doses of 1/10, 1/20 and 1/50 of the LD50 of the drug, established in an acute experiment, with daily use for 5 days was studied in white rats. As a result, it was found that doses of 350, 175 and 70 mg/kg with daily use in white outbred rats for 5 days are inoperative.

EFFICIENCY OF THE PREPARATION OF THE PROLONGED ACTION ON THE BASIS OF MOXIDECTIN "NEOTERICA PROTECTO SYRUP" IN ECTOAND ENDOPARASITOSIS OF CARNIVORE ANIMALS

This article presents the results of studies of the therapeutic and prophylactic efficacy of the drug "Neoterica Protecto Syrup" for arachnoentomoses and nematodes of domestic carnivores. The drug contains the active ingredient moxidectin, which provides a wide range of antiparasitic action of the drug against ecto- and endoparasites. The studies were conducted from April to August 2020 in veterinary clinics in Moscow and the Moscow region on dogs and cats free from parasites and naturally infested with fleas, lice, ixodid and scabies mites, intestinal nematodes and dirofilaria larvae. The animals were administered the drug once orally individually at a therapeutic dose at the rate of 1.5 mg moxidectin per 1 kg of animal weight. The diagnosis and efficacy of the diseases were confirmed by clinical (examination of the skin and hair for the presence of ectoparasites) and laboratory (Priselkova's method for detecting acariform mites in scrapings, the "thick crushed drop method" for detecting dirofilariae, Fülleborn's method for detecting nematode eggs) studies have confirmed the therapeutic efficacy the drug, the antiparasitic activity persisted for 90 days after application, which confirms the preventive effectiveness of the drug.