Widget Transactions Dynamic Processing Architecture Development

The article is devoted to the development of a widget's dynamic transaction processing architecture. An object is a hierarchical widget in a user interface organization. The subject is the process of the dynamic processing of widget transactions. The purpose of the article is to develop a dynamic transaction processing architecture) for a hierarchical widget. The article discusses the construction of a complex structured user interface in applications that are built on the basis of event-oriented programming. The article discusses the use of hierarchical widgets in companies such as Microsoft and Google, as well as existing developments related to hierarchical widgets. The main components of the dynamic processing of widget transactions, the main objects of the dynamic model are determined. A hierarchy of objects of the dynamic model of transaction processing of the widget is proposed. To interact with the dynamic model and its graphical representation, a special graphical notation is proposed. Dynamic processing of widget transactions is a new approach that has its advantages and disadvantages, the class of tasks being solved. The proposed architecture combines both work with unstructured data and the use of a hierarchical data model.

Energy Transfer as A Driving Force in Nucleic Acid–Protein Interactions

Many nucleic acid–protein structures have been resolved, though quantitative structure-activity relationship remains unclear in many cases. Thrombin complexes with G-quadruplex aptamers are striking examples of a lack of any correlation between affinity, interface organization, and other common parameters. Here, we tested the hypothesis that affinity of the aptamer–protein complex is determined with the capacity of the interface to dissipate energy of binding. Description and detailed analysis of 63 nucleic acid–protein structures discriminated peculiarities of high-affinity nucleic acid–protein complexes. The size of the amino acid sidechain in the interface was demonstrated to be the most significant parameter that correlates with affinity of aptamers. This observation could be explained in terms of need of efficient energy transfer from interacting residues. Application of energy dissipation theory provided an illustrative tool for estimation of efficiency of aptamer–protein complexes. These results are of great importance for a design of efficient aptamers.

Databases for Specialized Audiences: An Exploration of Online Access to the Nontextual Features of Greek New Testament Manuscripts

Since the beginning of the century, the digitization of medieval manuscripts has been a major concern of institutions in the possession of such material. This has led to the massive production of digital surrogates for online display. Preservation condition and temporal and spatial limitations are no longer restrictions for accessing these objects, making them easily available to a potentially larger public than before. The databases created for hosting the surrogates are designed for different categories of audience, with various standards in mind and different levels of technical sophistication. Although primarily accessed for the texts they bear, the digital surrogates of manuscripts are also the object of study of a specialized group of users interested in their physical features. This review will discuss whether databases that comprise digital surrogates of Greek New Testament manuscripts built by different types of institutions are efficient in addressing the needs of this admittedly small audience. I examine questions of content, interface, organization, and rationales behind the choices of their creators.