Does visual saliency affect decision-making?

In the present study, we explore potential effects of visual saliency on decision quality in context of multi-criteria decision-making (MCDM). We compare two visualization techniques: parallel coordinates (PC) and scatterplot matrices (SPM). We investigate the impact of saliency facilitated by means of either color or size. The saliency and visualization techniques were factors in our analysis, and effects were evaluated in terms of decision quality, attention, time on task, and confidence. Results show that the quality of choice and attention were comparable for all saliency conditions when SPM was used. For PC, we found a positive effect of color saliency both on the quality of choice and on attention. Different forms of saliency led to varying times on task in both PC and SPM; however, those variations were not significant. A comparison of PC and SPM shows, users spent less time on the task, obtained better decision quality, and were more confident with their decision when using PC. To summarize, our findings suggest that saliency can increase attention and decision quality in MCDM for certain visualization techniques and forms of saliency. Another contribution of this work is the novel suggestion of the method to elicit of users’ preferences; its potential benefits are discussed in the end of the paper. Graphic abstract

The selective estrogen receptor modulator tamoxifen protects against subtle cognitive decline and early markers of injury twenty-four hours after hippocampal silent infarct

Silent infarcts (SI) are subcortical cerebral infarcts that occur in the absence of typical symptoms associated with ischemia but are linked to cognitive decline and the development of dementia. There are no approved treatments for SI, but one potential treatment is tamoxifen, a selective estrogen receptor modulator. While SI can have long-term consequences, it is critical to establish whether treatments are able to selectively target its early consequences, to avoid progression to complete injury. We induced SI in the dorsal hippocampal CA1 of rats and assessed whether tamoxifen is protective 24 hours later against cognitive deficits and injury responses to SI including gliosis, apoptosis, inflammation and changes in estrogen receptors (ERs). Hippocampal SI led to subtle cognitive impairment on the object place recognition task, an effect ameliorated by tamoxifen administration. SI did not lead to detectable hippocampal cell loss but did increase apoptosis, astrogliosis, microgliosis and inflammation. Tamoxifen protected against the effects of SI on all measures except microgliosis. SI also increased ERα and decreased ERβ in the hippocampus, which was again mitigated by tamoxifen. Exploratory data analyses using scatterplot matrices and principal component analysis indicated that the SI rats given tamoxifen were indistinguishable from sham controls. Further, SI rats were significantly different from all other groups, an effect produced by low levels of ERα and increased apoptosis, gliosis, inflammation, ERβ, and time spent with the unmoved object. The results demonstrate that tamoxifen is protective against the early cellular and cognitive consequences of hippocampal SI as early as 24 hours after injury. This effect is driven by mitigation of apoptosis, gliosis, and inflammation and normalization of ER levels in the CA1, leading to improved cognitive outcomes after hippocampal SI.