Sub-Chronic Hepatotoxicity in Adult Wistar Rats Following Administration of Ocimum gratissimum Aqueous Extract

2012 ◽  
Vol 2 (1) ◽  
pp. 19-30 ◽  
Author(s):  
A. Ajibade
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Ocimum Gratissimum

scholarly journals Effects of Aqueous Extract of Ocimum gratissimum Leaves and Vitamin C on Lead Acetate-induced Changes in the Thymus of Adult Wistar Rats

2019 ◽  
pp. 1-9
Author(s):  
G. N. Okechukwu ◽  
E. Ezor ◽  
E. Finbarrs-Bello ◽  
L. N. Ebube ◽  
G. C. Uzomba ◽  
...  
Keyword(s):  
Vitamin C ◽  
Aqueous Extract ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Lead Toxicity ◽  
Wistar Rat ◽  
Ocimum Gratissimum ◽  
Ameliorative Effect ◽  
Male Wistar Rats ◽  
Induced Changes

Lead is a heavy metal found in earth’s crust. It is a widespread and insidious environmental toxin known as a severe and aggressive contaminant to human and animal organisms’ health status. This work is aimed at evaluating the effect of aqueous extract of Ocimum gratissimum (OG) on lead induced changes in the thymus of adult albino wistar rats. Thirty five male Wistar rats were used in the study and were randomly divided into seven groups with five rats in each group. The rats in Group one (G1) served as the Control and received distilled water. Group 2 received 120 mg/kg body weight (bwt) of lead acetate, G3 received 375 mg/kg bwt of OG only. G4 received 120 mg/kg bwt of lead acetate and OG extract at 375 mg/kg bwt., G5 received 120 mg/kg bwt of lead and OG at 750 mg/kg bwt. G6 received 375 mg/kg bwt of OG in two weeks followed by 120 mg/kg bwt of lead acetate for one week, while G7 received 120 mg/kg bwt of lead acetate and Vitamin C at 11900 mg/kg. All the administrations were carried out orally for twenty one (21) days. At the end of the administration, the rats were fasted for 24 hours. They weighted and humanely sacrificed via cervical dislocation. The thymus were harvested in all the groups and prepared for histological studies using routine haematoxylin and eosin (H&E) staining techniques. The result of the present study shows that lead possessed a distortive effect in the histoarchitecture of thymus of the wistar rat in G2 when compared with G1. Treatment of these experimental animals with vitamin C prove to posses more ameliorative effect in restoring the histoarchitecture on lead toxicity in the thymus closed to normal than OG. Therefore, it is suggested that aqueous extract OG can act via the same pathway as vitamin C, in maintaining the normal histological structures of the thymus of adult albino wistar rat exposed to lead toxicity.

scholarly journals Effects of Aqueous Extracts of Nigella sativa and Ocimum gratissimum on Electrolyte, Urea, Creatinine of Wistar Rat

2019 ◽  
pp. 1-8
Author(s):  
Okoye Ngozi Franca ◽  
Benjamin Prince
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Nigella Sativa ◽  
Negative Control ◽  
Time Dependent ◽  
Dependent Manner ◽  
Aqueous Extracts ◽  
Ocimum Gratissimum ◽  
The Third ◽  
Black Seed

Aim: Effects of aqueous extracts of Nigella sativa (black seed) and Ocimum gratissimum (scent leaf) on electrolytes, urea and creatinine of Wistar rats were investigated. Materials and Method: Twenty-five Wistar rats were used for the study, the rats were arranged into five groups with five rats in each of the groups. The rats had access to their normal feed but sucrose and margarine were used to induce hyperglycemia and hyperlipidemia respectively on the rats with the exception of the rats in the positive control group. The rats in the negative control were induced using the sucrose and margarine but were not treated using the aqueous extracts. The rats in the scent leaf group were treated with 2 ml of scent leaf aqueous extract, while the rats in the black seed group were treated with 2 ml of black seed aqueous extract. The rats in the black seed and scent leaf group were treated with 2 ml of the combined aqueous extract. Results: The result showed that the extracts decreased the levels of the electrolytes in the rats in a time-dependent manner with the highest decrease obtained on the third week of treatment with the extracts. The sodium levels (mmol/ml) on the third week of treatment showed for the negative control (193.83 ± 2.96), scent leaf (125.80 ± 8.27), black seed (119.60 ± 6.24), black seed and scent leaf (110.93 ± 10.14) (p<0.05).  The decrease for potassium levels (mEql/l) on the third week of treatment, showed for the negative control (0.11 ± 0.05), scent leaf (0.09 ± 0.14), black seed (0.08 ± 0.10), black seed and scent leaf (0.06 ± 0.11). Furthermore, the extracts also had a decreasing effect on the urea and creatinine in a time-dependent manner with the highest decrease obtained on the third week of treatment (p>0.05).  The urea levels (mmol/ml)) showed for the negative control (26.64 ± 0.33), scent leaf (16.73 ± 0.88), black seed (15.86 ± 2.31) and black seed and scent leaf (12.88 ± 1.98). The decrease for creatinine levels (mmol/l) showed for negative control (662.68 ± 18.00), scent leaf (287.10 ± 12.30), black seed (192.44 ± 10.44) and black seed and scent leaf (188.66 ± 10.88. Conclusion: The extracts significantly decreased the elevated electrolytes, urea and creatinine levels and therefore scent leaf and black seed can be used to restore kidney function.

scholarly journals Effect of aqueous extract of Ocimum gratissimum on acetaminophen induced renal toxicity in male wistar rats

2018 ◽  
Vol 12 (28) ◽  
pp. 522-527
Author(s):  
Linda Okerulu ◽  
Ani Celestine ◽  
Nworgu Choice ◽  
Uzoma Igwe ◽  
Emeka Ugwuishi ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Renal Toxicity ◽  
Ocimum Gratissimum ◽  
Male Wistar Rats

scholarly journals Effects of aqueous extract of Ocimum gratissimum on haematological parameters of Wistar rats

Biokemistri ◽  
2010 ◽  
Vol 20 (1) ◽  
Author(s):  
OR Jimoh ◽  
J Olaore ◽  
LA Olayaki ◽  
A Olawepo ◽  
SA Biliaminu
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Haematological Parameters ◽  
Ocimum Gratissimum

Biochemical and Haemopoietic Effects of Aqueous Extract of Gnetum Africanum (Ukazi) on Male and Female Albino Wistar Rats

2018 ◽  
Vol 8 (4) ◽  
pp. 061-065
Author(s):  
F.N OGUWIKE ◽  
◽  
I.C IFEDI ◽  
C.N DIM ◽  
C.P IGWEDIBIA ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Male And Female

scholarly journals Antioxidant Evaluation of the Aqueous Extract of Hulls of Campsiandra laurifolia in Colitis Induced by Acetic Acid in Wistar Rats

2021 ◽  
Vol 41 (02) ◽  
pp. 138-144
Author(s):  
Lucas Petitemberte de Souza ◽  
Henrique Sarubbi Fillmann ◽  
Sandielly Rebeca Benitez da Fonseca ◽  
Marilda da Silva Brasil ◽  
Norma Anair Possa Marroni ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Phenolic Compounds ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Experimental Colitis ◽  
Anal Pressure ◽  
Antioxidant Power ◽  
Significance Level ◽  
Sphincter Anal

AbstractDue to the ethnopharmacological use of Campsiandra laurifolia (Fabaceae), popularly known as Acapurana, to treat wounds and ulcers, associated with the lack of alternative treatments for intestinal inflammations such as ulcerative colitis (UC), the present work sought to characterize its phytochemical and antioxidant activities, and to evaluate remedial action in experimental colitis with acetic acid. Phytochemical analyzes were performed through qualitative and quantitative colorimetric tests of the main secondary metabolites. In the colitis model, 24 male Wistar rats aged ± 60 days old were used, divided into 4 groups: Control (CO) control + aqueous extract of C. laurifolia 50 mg/kg (CO + A50); Colitis (CL); and Colitis + aqueous extract of C. laurifolia 50 mg/kg (CL + A50). Measurement of sphincter anal pressure and histological tests of the large intestine, lipoperoxidation (LPO), enzyme activity of superoxide dismutase (SOD), and levels of glutathione (GSH) were performed. For statistical analysis, the oxidative stress (OS) results were expressed as means ± standard error, adopting a significance level of p < 0.05. The screening indicated the presence of flavonoids, saponins and tannins in the extract, with high levels of phenolic compounds and tannins, and was related to high antioxidant capacity. In the histological analysis, the CL group presented loss of the crypts, edema and inflammatory infiltrate. The use of C. laurifolia extract restructured the crypts, decreased edema and increased sphincter anal pressure, with a decrease in LPO, SOD, and an increase in GSH. It is suggested that the use of C. laurifolia extract reduces OS due to its antioxidant power conferred by the phenolic compounds present in the extract.

Ocimum gratissimum enhances insulin sensitivity in male Wistar rats with dexamethasone-induced insulin resistance

2021 ◽  
Author(s):  
Shehu-Tijani Toyin Shittu ◽  
Taye Jemilat Lasisi ◽  
Seyid Alli-Sisse Shittu ◽  
Adeyinka Adeyemi ◽  
Tolulope James Adeoye ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Wistar Rats ◽  
Ocimum Gratissimum ◽  
Male Wistar Rats
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