scholarly journals Histological and Biochemical effects of aqueous extract of ocimum gratissimum on the liver and kidney of adult wistar rats

2014 ◽  
Vol 2 (4) ◽  
pp. 59-64 ◽  
Author(s):  
OA Ebeye ◽  
OV Ekundina ◽  
IE Wilkie
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Ocimum Gratissimum ◽  
Biochemical Effects ◽  
Liver And Kidney

Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat diet

2018 ◽  
Vol 28 (5) ◽  
pp. 1197-1203 ◽  
Author(s):  
Mohammad Mahdi Zangeneh ◽  
Saman Salmani ◽  
Akram Zangeneh ◽  
Reza Khedri ◽  
Mohammad Saeid Zarei
Keyword(s):  
Aqueous Extract ◽  
High Fat Diet ◽  
Wistar Rats ◽  
High Fat ◽  
Biochemical Effects ◽  
Tragopogon Graminifolius ◽  
Liver Tissues

scholarly journals Bougainvillea spectabilisExhibits Antihyperglycemic and Antioxidant Activities in Experimental Diabetes

2015 ◽  
Vol 21 (3) ◽  
pp. 177-185 ◽  
Author(s):  
Pratibha Chauhan ◽  
Sunil Mahajan ◽  
Archana Kulshrestha ◽  
Sadhana Shrivastava ◽  
Bechan Sharma ◽  
...  
Keyword(s):  
Dna Damage ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Glycosylated Hemoglobin ◽  
Histological Changes ◽  
Liver And Kidney ◽  
Bougainvillea Spectabilis ◽  
Streptozotocin Induced Diabetes ◽  
Kidney Functions

The study investigates the effects of aqueous extract of Bougainvillea spectabilis leaves on blood glucose, glycosylated hemoglobin, lipid profile, oxidative stress, and on DNA damage, if any, as well as on liver and kidney functions in streptozotocin-induced diabetes in Wistar rats. Daily administration of the aqueous extract of B spectabilis leaves for 28 days resulted in significant reduction in hyperglycemia and hyperlipidemia as evident from restoration of relevant biochemical markers following extract administration. The extract also exhibited significant antioxidant activity as evidenced from the enzymatic and nonenzymatic responses and DNA damage markers. The extract restored kidney and liver functions to normal and proved to be nontoxic. A marked improvement in the histological changes of tissues was also observed. The present study documented antihyperglycemic, antihyperlipidemic, and antioxidative potentials of the aqueous extract of B spectabilis leaves without any toxicity in streptozotocin-treated Wistar rats.

scholarly journals Effects of Aqueous Extract of Ocimum gratissimum Leaves and Vitamin C on Lead Acetate-induced Changes in the Thymus of Adult Wistar Rats

2019 ◽  
pp. 1-9
Author(s):  
G. N. Okechukwu ◽  
E. Ezor ◽  
E. Finbarrs-Bello ◽  
L. N. Ebube ◽  
G. C. Uzomba ◽  
...  
Keyword(s):  
Vitamin C ◽  
Aqueous Extract ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Lead Toxicity ◽  
Wistar Rat ◽  
Ocimum Gratissimum ◽  
Ameliorative Effect ◽  
Male Wistar Rats ◽  
Induced Changes

Lead is a heavy metal found in earth’s crust. It is a widespread and insidious environmental toxin known as a severe and aggressive contaminant to human and animal organisms’ health status. This work is aimed at evaluating the effect of aqueous extract of Ocimum gratissimum (OG) on lead induced changes in the thymus of adult albino wistar rats. Thirty five male Wistar rats were used in the study and were randomly divided into seven groups with five rats in each group. The rats in Group one (G1) served as the Control and received distilled water. Group 2 received 120 mg/kg body weight (bwt) of lead acetate, G3 received 375 mg/kg bwt of OG only. G4 received 120 mg/kg bwt of lead acetate and OG extract at 375 mg/kg bwt., G5 received 120 mg/kg bwt of lead and OG at 750 mg/kg bwt. G6 received 375 mg/kg bwt of OG in two weeks followed by 120 mg/kg bwt of lead acetate for one week, while G7 received 120 mg/kg bwt of lead acetate and Vitamin C at 11900 mg/kg. All the administrations were carried out orally for twenty one (21) days. At the end of the administration, the rats were fasted for 24 hours. They weighted and humanely sacrificed via cervical dislocation. The thymus were harvested in all the groups and prepared for histological studies using routine haematoxylin and eosin (H&E) staining techniques. The result of the present study shows that lead possessed a distortive effect in the histoarchitecture of thymus of the wistar rat in G2 when compared with G1. Treatment of these experimental animals with vitamin C prove to posses more ameliorative effect in restoring the histoarchitecture on lead toxicity in the thymus closed to normal than OG. Therefore, it is suggested that aqueous extract OG can act via the same pathway as vitamin C, in maintaining the normal histological structures of the thymus of adult albino wistar rat exposed to lead toxicity.

Aqueous extract of Senecio candicans DC induce liver and kidney damage in a sub-chronic oral toxicity study in Wistar rats

2016 ◽  
Vol 79 ◽  
pp. 25-34 ◽  
Author(s):  
Hariprasath Lakshmanan ◽  
Jegadeesh Raman ◽  
Arjun Pandian ◽  
Kumaresan Kuppamuthu ◽  
Raaman Nanjian ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Kidney Damage ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Liver And Kidney ◽  
Liver And Kidney Damage

scholarly journals Protective effect of aqueous extract of Lophira lanceolata leaf against cisplatin-induced hepatorenal injuries and dyslipidemia in Wistar rats

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Raphael John Ogbe ◽  
Samuel Peter Agbese ◽  
Adakole Hyacinth Abu
Keyword(s):  
Protective Effect ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Ldl Cholesterol ◽  
Control Group ◽  
Group I ◽  
Medicinal Plant Extracts ◽  
Liver And Kidney ◽  
Lophira Lanceolata ◽  
Group Ii

Abstract Background Hepatorenal injuries and dyslipidemia are common global health challenges but medicinal plant extracts may have potential to prevent them. Thus, this study evaluated the protective effect of aqueous extract of Lophira lanceolata leaf (LLE) against cisplatin-induced hepatorenal injuries and dyslipidemia in albino Wistar rats. Methods Thirty rats were randomly divided into 6 groups of 5 rats each. Group I rats received distilled water and served as control, group II rats were given 5 mg/kg cisplatin (CIS) intraperitoneally, groups III and IV rats were treated with 200 and 400 mg/kg LLE respectively for 26 days by oral gavages while groups V and VI rats were treated with 200 and 400 mg/kg LLE respectively, followed by CIS on the 21st day as in group II. About 24 h after treatment, blood was collected from the rats; then serum was separated and used for estimations of biochemical parameters. The kidney and liver of rats were removed, rinsed in normal saline, stored in 10% formalin and used for histological analyses. Results The biomarkers of hepatic (Aminotransferases, Alkaline phosphatase and Bilirubin) and renal (urea and creatinine) injuries, and dyslipidemia (Total cholesterol, triglycerides and LDL-cholesterol) significantly (p < 0.05) increased in the rats exclusively exposed to cisplatin when compared with normal control. However, treatment of cisplatin-exposed rats with 200 and 400 mg/kg LLE significantly (p < 0.05) reduced the levels of these biomarkers of hepatorenal injuries and dyslipidemia when compared with cisplatin control. Photomicrographs showed pathological signs in the liver and kidney of rats exclusively exposed to cisplatin, but there was moderate protection of these tissues in the rats treated with LLE and cisplatin. Conclusion The current findings have shown that Lophira lanceolata leaf extract may provide moderate protection against cisplatin-induced hepatorenal injuries and dyslipidemia in albino Wistar rats.

scholarly journals Acute and Subacute Oral Toxicity Studies of the Aqueous Extract from the Stem Bark of Ricinodendron Rautanenii Schinz (Euphorbiaceae) in Wistar Rats

2020 ◽  
Vol 5 (08) ◽  
pp. 301-308
Author(s):  
Jacquy Joyce Wanche Kojom ◽  
Edwige Laure Nguemfo ◽  
Marie-Claire Tchamadeu ◽  
Calvin Bogning Zangueu ◽  
Edwige Laure Lappa ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Hematological Parameters ◽  
Stem Bark ◽  
Female Rats ◽  
Histopathological Analysis ◽  
Toxicity Assay ◽  
Subacute Toxicity ◽  
Male And Female Rats ◽  
Liver And Kidney

Ricinodendron rautanenii is a plant, used in traditional medecine to treat fever, eczema, back pain, cancer and stomacal disorders. This work was carried out to evaluate the safety of the aqueous extract from the stem bark of Ricinodendron rautanenii by determining its potential toxicity after acute and subacute administration in Wistar rats. In Acute toxicity assay, the animals received the extract at the single dose of 5000 mg/Kg and were observed during 48h for mortality and any toxicity manifestations. General behavior, adverse effects and mortality were determined for up to 14 days post treatment. In subacute toxicity assay, extract was given orally to rats at doses of 6, 20, 40 and 80 mg/kg/day for 28 days respectively. Animal body weight, water and food intake, biochemical and hematological parameters were determined. Liver and kidney were examined histologically for any signs of organ damage. No behavioral changes or mortality were recorded in the treated groups. No significant hematological changes were observed in the both sex. The biochemical analysis indicated a significant increase of high density lipoprotein levels in both male and female rats. Histopathological analysis of the liver and kidney did not show any observable cellular damages. The overall finding of this study suggest that, extract of Ricinodendron rautanenii did not cause any death up to a dose of 5000 mg/kg and can be considered non-toxic. Biochemical and histological studies of the extract did not revealed major signs in subacute toxicity.

scholarly journals Effects of Aqueous Extracts of Nigella sativa and Ocimum gratissimum on Electrolyte, Urea, Creatinine of Wistar Rat

2019 ◽  
pp. 1-8
Author(s):  
Okoye Ngozi Franca ◽  
Benjamin Prince
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Nigella Sativa ◽  
Negative Control ◽  
Time Dependent ◽  
Dependent Manner ◽  
Aqueous Extracts ◽  
Ocimum Gratissimum ◽  
The Third ◽  
Black Seed

Aim: Effects of aqueous extracts of Nigella sativa (black seed) and Ocimum gratissimum (scent leaf) on electrolytes, urea and creatinine of Wistar rats were investigated. Materials and Method: Twenty-five Wistar rats were used for the study, the rats were arranged into five groups with five rats in each of the groups. The rats had access to their normal feed but sucrose and margarine were used to induce hyperglycemia and hyperlipidemia respectively on the rats with the exception of the rats in the positive control group. The rats in the negative control were induced using the sucrose and margarine but were not treated using the aqueous extracts. The rats in the scent leaf group were treated with 2 ml of scent leaf aqueous extract, while the rats in the black seed group were treated with 2 ml of black seed aqueous extract. The rats in the black seed and scent leaf group were treated with 2 ml of the combined aqueous extract. Results: The result showed that the extracts decreased the levels of the electrolytes in the rats in a time-dependent manner with the highest decrease obtained on the third week of treatment with the extracts. The sodium levels (mmol/ml) on the third week of treatment showed for the negative control (193.83 ± 2.96), scent leaf (125.80 ± 8.27), black seed (119.60 ± 6.24), black seed and scent leaf (110.93 ± 10.14) (p<0.05).  The decrease for potassium levels (mEql/l) on the third week of treatment, showed for the negative control (0.11 ± 0.05), scent leaf (0.09 ± 0.14), black seed (0.08 ± 0.10), black seed and scent leaf (0.06 ± 0.11). Furthermore, the extracts also had a decreasing effect on the urea and creatinine in a time-dependent manner with the highest decrease obtained on the third week of treatment (p>0.05).  The urea levels (mmol/ml)) showed for the negative control (26.64 ± 0.33), scent leaf (16.73 ± 0.88), black seed (15.86 ± 2.31) and black seed and scent leaf (12.88 ± 1.98). The decrease for creatinine levels (mmol/l) showed for negative control (662.68 ± 18.00), scent leaf (287.10 ± 12.30), black seed (192.44 ± 10.44) and black seed and scent leaf (188.66 ± 10.88. Conclusion: The extracts significantly decreased the elevated electrolytes, urea and creatinine levels and therefore scent leaf and black seed can be used to restore kidney function.

scholarly journals Effect of aqueous extract of Ocimum gratissimum on acetaminophen induced renal toxicity in male wistar rats

2018 ◽  
Vol 12 (28) ◽  
pp. 522-527
Author(s):  
Linda Okerulu ◽  
Ani Celestine ◽  
Nworgu Choice ◽  
Uzoma Igwe ◽  
Emeka Ugwuishi ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Renal Toxicity ◽  
Ocimum Gratissimum ◽  
Male Wistar Rats
Sign in / Sign up

Export Citation Format

Share Document