scholarly journals Small Cell Variant of Medullary Thyroid Carcinoma: A Possible Treatment

Cureus ◽  
2020 ◽  
Author(s):  
John Sherret ◽  
Mohammad Alomari ◽  
Joshua Coleman ◽  
Agnes Hamati
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Small Cell ◽  
Medullary Thyroid ◽  
Small Cell Variant ◽  
Cell Variant

scholarly journals Small cell medullary thyroid carcinoma: A diagnostic dilemma

2017 ◽  
Vol 60 (4) ◽  
pp. 562 ◽  
Author(s):  
Shubhada Kane ◽  
Anuj Verma ◽  
Sushant Vinarkar ◽  
AnilK D'Cruz
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Small Cell ◽  
Diagnostic Dilemma ◽  
Medullary Thyroid

Hepatic Metastases from the Spindle Cell Variant of Medullary Thyroid Carcinoma

2001 ◽  
Vol 45 (6) ◽  
pp. 1022-1026 ◽  
Author(s):  
Carolina Ibarrola de Andrés ◽  
Victor Manuel Castellano Megías ◽  
Claudio Ballestin Carcavilla ◽  
Nuria Alberti Masgrau ◽  
Andrés Perez Barrios ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Spindle Cell ◽  
Hepatic Metastases ◽  
Medullary Thyroid ◽  
Cell Variant

Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma

1990 ◽  
Vol 10 (4) ◽  
pp. 1773-1778
Author(s):  
A de Bustros ◽  
R Y Lee ◽  
D Compton ◽  
T Y Tsong ◽  
S B Baylin ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Lung Carcinoma ◽  
Dna Sequences ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Medullary Thyroid ◽  
Calcitonin Gene

Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5' DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.

scholarly journals Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma.

1990 ◽  
Vol 10 (4) ◽  
pp. 1773-1778 ◽  
Author(s):  
A de Bustros ◽  
R Y Lee ◽  
D Compton ◽  
T Y Tsong ◽  
S B Baylin ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Lung Carcinoma ◽  
Dna Sequences ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Medullary Thyroid ◽  
Calcitonin Gene

Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5' DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.

scholarly journals Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yan Xia Wang ◽  
Shou Jing Yang
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Spindle Cell ◽  
Regional Lymph Node ◽  
Medullary Thyroid ◽  
Fibrous Stroma ◽  
Immunohistochemical Markers ◽  
Clinicopathologic Study ◽  
Regional Lymph Node Dissection ◽  
Cell Variant

Abstract Background Medullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Among them, spindle cell variant is extremely rare. Case presentation Here we describe 4 cases of spindle cell variant of MTC collected from 2012 to 2019. Ultrasound showed solid and hypoechoic nodules. Three patients underwent total thyroidectomy and regional lymph node dissection, and 1 patient underwent thyroid mass resection. Histologically, the tumors showed spindle shaped cells in bundles or interlaced arrangement, separated by hyalinised fibrous stroma that contained amyloid deposits. Immunohistochemistry showed that the tumor cells were positive for calcitonin, chromogranin A, synaptophysin, CD56, and TTF-1, but negative for other lineage-specific markers. Conclusions We report 4 rare cases of spindle cell variant of MTC. Due to its rarity and special morphology, the diagnosis of spindle cell variant MTC relies on its morphology and immunohistochemical markers to avoid misdiagnosis.

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