Hepatic Metastases from the Spindle Cell Variant of Medullary Thyroid Carcinoma

2001 ◽  
Vol 45 (6) ◽  
pp. 1022-1026 ◽  
Author(s):  
Carolina Ibarrola de Andrés ◽  
Victor Manuel Castellano Megías ◽  
Claudio Ballestin Carcavilla ◽  
Nuria Alberti Masgrau ◽  
Andrés Perez Barrios ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Spindle Cell ◽  
Hepatic Metastases ◽  
Medullary Thyroid ◽  
Cell Variant

scholarly journals Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yan Xia Wang ◽  
Shou Jing Yang
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Spindle Cell ◽  
Regional Lymph Node ◽  
Medullary Thyroid ◽  
Fibrous Stroma ◽  
Immunohistochemical Markers ◽  
Clinicopathologic Study ◽  
Regional Lymph Node Dissection ◽  
Cell Variant

Abstract Background Medullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Among them, spindle cell variant is extremely rare. Case presentation Here we describe 4 cases of spindle cell variant of MTC collected from 2012 to 2019. Ultrasound showed solid and hypoechoic nodules. Three patients underwent total thyroidectomy and regional lymph node dissection, and 1 patient underwent thyroid mass resection. Histologically, the tumors showed spindle shaped cells in bundles or interlaced arrangement, separated by hyalinised fibrous stroma that contained amyloid deposits. Immunohistochemistry showed that the tumor cells were positive for calcitonin, chromogranin A, synaptophysin, CD56, and TTF-1, but negative for other lineage-specific markers. Conclusions We report 4 rare cases of spindle cell variant of MTC. Due to its rarity and special morphology, the diagnosis of spindle cell variant MTC relies on its morphology and immunohistochemical markers to avoid misdiagnosis.

scholarly journals The role of hepatic trans-arterial chemoembolization in metastatic medullary thyroid carcinoma: a specialist center experience and review of the literature

2017 ◽  
Vol 176 (4) ◽  
pp. 463-470 ◽  
Author(s):  
S Grozinsky-Glasberg ◽  
A I Bloom ◽  
N Lev-Cohain ◽  
A Klimov ◽  
H Besiso ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Liver Metastases ◽  
Medullary Thyroid Carcinoma ◽  
Clinical Improvement ◽  
Tumor Response ◽  
Liver Volume ◽  
Hepatic Metastases ◽  
Case Series ◽  
Medullary Thyroid ◽  
Arterial Chemoembolization

BackgroundLiver metastases are relatively common in patients with metastatic medullary thyroid carcinoma (MTC), carrying a negative impact on disease prognosis. The options for selective therapy of liver metastases in MTC patients are limited to catheter-guided procedures such as trans-arterial chemoembolization (TACE). Data regarding the effectiveness and safety of this procedure in MTC are limited.AimTo explore the clinical outcome, survival and safety profile of TACE for liver metastases in a group of MTC patients.MethodsRetrospective case series of patients treated at a single tertiary University Medical Center from 2005 to 2015.ResultsSeven consecutive patients (mean age 64.5 ± 10.9 years, 5 females) with histologically confirmed MTC with liver metastases were included. Metastatic involvement of the liver was less than 50% of the liver volume in all patients. The median size of the largest liver lesion was 40 ± 6.9 mm. The patients underwent in total 20 sessions of TACE. Clinical improvement as well as tumor response (PR) were observed in all patients. The median time to tumor progression was 38 months (range 8–126). Three patients were still alive at the end of the follow-up period (a median overall survival rate of 57 ± 44 months).ConclusionTACE in MTC patients with hepatic metastases is usually well tolerated and induces both clinical improvement and tumor response for prolonged periods of time in the majority of patients. This therapeutic option should always be considered, irrespective of the presence of extrahepatic metastasis.

Visualization of Lymph Nodal and Hepatic Metastases of Medullary Thyroid Carcinoma on 18F-Fluoride PET/CT

2015 ◽  
Vol 40 (11) ◽  
pp. 895-896 ◽  
Author(s):  
Rômulo Hermeto Bueno do Vale ◽  
José Flávio Gomes Marin ◽  
Paulo Schiavom Duarte ◽  
Marcelo Tatit Sapienza ◽  
Carlos Alberto Buchpiguel
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Hepatic Metastases ◽  
Medullary Thyroid ◽  
Pet Ct ◽  
18F Fluoride

Selective arterial chemoembolization for hepatic metastases from medullary thyroid carcinoma

Surgery ◽  
2005 ◽  
Vol 138 (6) ◽  
pp. 986-993 ◽  
Author(s):  
Kerstin Lorenz ◽  
Michael Brauckhoff ◽  
Curd Behrmann ◽  
Carsten Sekulla ◽  
Jörg Ukkat ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Hepatic Metastases ◽  
Medullary Thyroid ◽  
Arterial Chemoembolization
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