Pseudoangiosarcomatous features in medullary thyroid carcinoma spindle-cell variant. Report of a case studied by FNA and immunohistochemistry

2007 ◽  
Vol 35 (7) ◽  
pp. 424-428 ◽  
Author(s):  
Juan B. Laforga ◽  
F. Ignacio Aranda
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Spindle Cell ◽  
Medullary Thyroid ◽  
Cell Variant

Hepatic Metastases from the Spindle Cell Variant of Medullary Thyroid Carcinoma

2001 ◽  
Vol 45 (6) ◽  
pp. 1022-1026 ◽  
Author(s):  
Carolina Ibarrola de Andrés ◽  
Victor Manuel Castellano Megías ◽  
Claudio Ballestin Carcavilla ◽  
Nuria Alberti Masgrau ◽  
Andrés Perez Barrios ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Spindle Cell ◽  
Hepatic Metastases ◽  
Medullary Thyroid ◽  
Cell Variant

scholarly journals Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yan Xia Wang ◽  
Shou Jing Yang
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Spindle Cell ◽  
Regional Lymph Node ◽  
Medullary Thyroid ◽  
Fibrous Stroma ◽  
Immunohistochemical Markers ◽  
Clinicopathologic Study ◽  
Regional Lymph Node Dissection ◽  
Cell Variant

Abstract Background Medullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Among them, spindle cell variant is extremely rare. Case presentation Here we describe 4 cases of spindle cell variant of MTC collected from 2012 to 2019. Ultrasound showed solid and hypoechoic nodules. Three patients underwent total thyroidectomy and regional lymph node dissection, and 1 patient underwent thyroid mass resection. Histologically, the tumors showed spindle shaped cells in bundles or interlaced arrangement, separated by hyalinised fibrous stroma that contained amyloid deposits. Immunohistochemistry showed that the tumor cells were positive for calcitonin, chromogranin A, synaptophysin, CD56, and TTF-1, but negative for other lineage-specific markers. Conclusions We report 4 rare cases of spindle cell variant of MTC. Due to its rarity and special morphology, the diagnosis of spindle cell variant MTC relies on its morphology and immunohistochemical markers to avoid misdiagnosis.

scholarly journals Small Cell Variant of Medullary Thyroid Carcinoma: A Possible Treatment

Cureus ◽  
2020 ◽  
Author(s):  
John Sherret ◽  
Mohammad Alomari ◽  
Joshua Coleman ◽  
Agnes Hamati
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Small Cell ◽  
Medullary Thyroid ◽  
Small Cell Variant ◽  
Cell Variant

Abstract #832: Metastatic Medullary Thyroid Carcinoma Presenting as Ectopic Cushing Syndrome

2017 ◽  
Vol 23 ◽  
pp. 179
Author(s):  
Sandeep Donagaon ◽  
Pramila Kalra ◽  
Anil Kumar ◽  
K. Harish ◽  
Shamim Sheik ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Cushing Syndrome ◽  
Medullary Thyroid
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