scholarly journals Small Intestinal Adenocarcinoma in a Patient With Celiac Disease

Cureus ◽  
2021 ◽  
Author(s):  
Mohammad Abudalou ◽  
Ali F Al Sbihi ◽  
Aleksandr Perepletchikov ◽  
Christopher Stallwood
Keyword(s):  
Celiac Disease ◽  
Small Intestinal ◽  
Small Intestinal Adenocarcinoma

scholarly journals Occult Celiac Disease in an Octogenarian Presenting with a Small Intestinal Adenocarcinoma

1994 ◽  
Vol 8 (6) ◽  
pp. 354-357 ◽  
Author(s):  
Hugh James Freeman
Keyword(s):  
Elderly Patient ◽  
Celiac Disease ◽  
Gastrointestinal Tract ◽  
Gluten Free ◽  
Duodenal Adenocarcinoma ◽  
Histological Studies ◽  
Small Bowel Carcinoma ◽  
Small Intestinal ◽  
Upper Gastrointestinal ◽  
Small Intestinal Adenocarcinoma

An 85-year-old male initially presented with an obstructed upper gastrointestinal tract associated with a duodenal adenocarcinoma. Subsequent histological studies revealed occult celiac disease, an associated condition that otherwise would not have been recognized in this elderly patient. The celiac disease responded to a gluten-free diet, even in the presence of an intestinal adenocarcinoma. This report suggests that celiac disease and small bowel carcinoma may coexist more frequently than is appreciated.

scholarly journals Neoplastic Disorders in 100 Patients with Adult Celiac Disease

1996 ◽  
Vol 10 (3) ◽  
pp. 163-166 ◽  
Author(s):  
HUGH J Freeman
Keyword(s):  
Celiac Disease ◽  
Malignant Lymphoma ◽  
Biliary Tract ◽  
Autoimmune Thyroiditis ◽  
Dermatitis Herpetiformis ◽  
Immune Mediated ◽  
Adult Celiac Disease ◽  
Neoplastic Disorders ◽  
Small Intestinal ◽  
Small Intestinal Adenocarcinoma

Previous reports have suggested that the incidence of some neoplastic disorders, particularly malignant lymphoma, is increased in patients with celiac disease. In this study, the type and number of neoplastic disorders detected in 100 consecutive celiac disease patients were explored. Sixty-five patients were initially diagnosed with celiac disease before, and 35 after, age 60 years. Ten elderly celiac patients had lymphoma or small intestinal adenocarcinoma. Although the overall incidence of malignant lymphoma was 8%, similar to that in other centres, the incidence in elderly celiac patients was 23% in this study. Celiac disease was detected before or after the diagnosis of lymphoma or small intestinal adenocarcinoma. In some patients, epithelial lymphocytosis was evident in the gastric, colonic or biliary tract epithelium. In addition, other immune-mediated disorders, dermatitis herpetiformis and autoimmune thyroiditis, were common. Finally, other malignant disorders of the esophagus, stomach and colon were not detected.

SMALL INTESTINAL ADENOCARCINOMA IN CELIAC DISEASE

2004 ◽  
Vol 99 ◽  
pp. S198-S199
Author(s):  
Chad E. Potteiger ◽  
James Brady ◽  
Diane Leonard ◽  
Donald Schneider
Keyword(s):  
Celiac Disease ◽  
Small Intestinal ◽  
Small Intestinal Adenocarcinoma

scholarly journals Contribution of Infectious Agents to the Development of Celiac Disease

2021 ◽  
Vol 9 (3) ◽  
pp. 547
Author(s):  
Daniel Sánchez ◽  
Iva Hoffmanová ◽  
Adéla Szczepanková ◽  
Věra Hábová ◽  
Helena Tlaskalová-Hogenová
Keyword(s):  
Celiac Disease ◽  
Intestinal Mucosa ◽  
Wheat Gluten ◽  
Small Intestinal Mucosa ◽  
Beneficial Effects ◽  
Immune Mediated ◽  
Healthy State ◽  
Food Antigens ◽  
Small Intestinal ◽  
And Function

The ingestion of wheat gliadin (alcohol-soluble proteins, an integral part of wheat gluten) and related proteins induce, in genetically predisposed individuals, celiac disease (CD), which is characterized by immune-mediated impairment of the small intestinal mucosa. The lifelong omission of gluten and related grain proteins, i.e., a gluten-free diet (GFD), is at present the only therapy for CD. Although a GFD usually reduces CD symptoms, it does not entirely restore the small intestinal mucosa to a fully healthy state. Recently, the participation of microbial components in pathogenetic mechanisms of celiac disease was suggested. The present review provides information on infectious diseases associated with CD and the putative role of infections in CD development. Moreover, the involvement of the microbiota as a factor contributing to pathological changes in the intestine is discussed. Attention is paid to the mechanisms by which microbes and their components affect mucosal immunity, including tolerance to food antigens. Modulation of microbiota composition and function and the potential beneficial effects of probiotics in celiac disease are discussed.

Collagenous Sprue: A Rare, Severe Small-Bowel Malabsorptive Disorder

2011 ◽  
Vol 135 (6) ◽  
pp. 803-809
Author(s):  
Xiangrong Zhao ◽  
Rebecca L. Johnson
Keyword(s):  
Celiac Disease ◽  
Medical Literature ◽  
Case Reports ◽  
Disease Entity ◽  
Review Of The Literature ◽  
Molecular Features ◽  
Refractory Sprue ◽  
Exact Etiology ◽  
Sporadic Cases ◽  
Small Intestinal

Abstract Collagenous sprue is a severe malabsorptive disorder, histologically characterized by small intestinal villous and crypt atrophy, and a subepithelial collagen deposit, thicker than 12 µm, that entraps lamina propria cellular elements. Collagenous sprue is a rare disease entity, with only about 60 sporadic cases reported worldwide since it was first described in 1947. Its exact etiology is still under investigation, and its relationship with classic celiac disease and other refractory, spruelike intestinal disorders remains controversial. Two larger-scale studies, in 2009, brought new insights into this elusive, yet emerging, topic. Here, we present a review of the literature on the possible etiology of collagenous sprue, its proposed links to classic celiac disease and to refractory sprue, and its clinical, biochemical, histologic, and molecular features. To our knowledge, all case reports on collagenous sprue in the medical literature to date are summarized.

M2026 Small Intestinal Release Mesalamine for Treatment of Refractory Celiac Disease

2009 ◽  
Vol 136 (5) ◽  
pp. A-469
Author(s):  
Shailaja Jamma ◽  
Daniel A. Leffler ◽  
Melinda Dennis ◽  
Bakht Roshan ◽  
Ciaran P. Kelly
Keyword(s):  
Celiac Disease ◽  
Refractory Celiac Disease ◽  
Small Intestinal
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