scholarly journals Anemia and Cost-Effectiveness of Complete Blood Count Testing Among Pregnant Women at King Abdulaziz University Hospital: A Single Tertiary Center Experience

Cureus ◽  
2020 ◽  
Author(s):  
Anas M Fallatah ◽  
Anas E Bifari ◽  
Hisham Z Alshehri ◽  
Sahal M Wali ◽  
Saleh A Alghamdi ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Pregnant Women ◽  
Blood Count ◽  
Complete Blood Count ◽  
University Hospital ◽  
Tertiary Center ◽  
King Abdulaziz University

scholarly journals Anti-toxoplasma Antibody Prevalence and Cost-effectiveness in Pregnant Women at the King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Cureus ◽  
2020 ◽  
Author(s):  
Ashwag H Mohajab ◽  
Hisham Z Alshehri ◽  
Riyadh O Shati ◽  
Ahmed A Alshehri ◽  
Mohammed A Alafghani ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Cost Effectiveness ◽  
Pregnant Women ◽  
University Hospital ◽  
Antibody Prevalence ◽  
King Abdulaziz University

scholarly journals Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions

2021 ◽  
Author(s):  
Ümit Görkem ◽  
Özgür Kan ◽  
Mehmet Ömer Bostancı ◽  
Deniz Taşkıran ◽  
Hasan Ali İnal
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Pregnancy Outcomes ◽  
Significant Relationship ◽  
Blood Count ◽  
Complete Blood Count ◽  
First Trimester ◽  
Study Groups ◽  
Control Group ◽  
Gestational Stage

Objective: Spontaneous abortion is the most common complication of early pregnancy, affecting up to 20% of recognized pregnancies. Kisspeptin is predominantly released by placental syncytiotrophoblasts, and regulates their placental invasion into the uterine matrices. We aimed to establish an association of serum kisspeptin levels with pregnancy outcomes during the early gestational stage of the first trimester. Method: In this prospective study, 90 pregnant women in their 7 to 8 6/7 gestational weeks were classified into three groups: (i) The control group, consisting of healthy pregnant women (n=30), (ii) the threatened abortion group (n=30), and (iii) the spontaneous abortion group (n=30). The maternal serum samples were analyzed for complete blood count parameters and kisspeptin levels. Results: There was no statistical difference regarding body mass index (BMI) and gestational age (p=0.370). Regarding detailed obstetric notations, including gravida, parity, abortion, and living children, socioeconomic levels, and employment rates, all study groups were comparable (p>0.05, for all). No significant association was found regarding the biochemical parameters of complete blood count, including neutrophil, lymphocyte, and platelet concentrations, as well as neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) (p>0.05, for all). The median serum kisspeptin levels of the study groups did not differ between the groups (p=0.153). Correlation analysis revealed no significant relationship between serum kisspeptin levels and other study parameters in any study groups (p>0.05, for all) Conclusions: We found no statistically significant relationship between serum kisspeptin concentrations and pregnancy outcomes in the early gestational stage of the first trimester, and serum kisspeptin concentrations did not seem to be a reliable marker to distinguish abortion status from viable pregnancy

scholarly journals Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M'diq-Fnideq provinces)

2018 ◽  
Vol 29 ◽  
Author(s):  
Saad Bakrim ◽  
Youssef Motiaa ◽  
Ali Ouarour ◽  
Azlarab Masrar
Keyword(s):  
Pregnant Women ◽  
Reference Values ◽  
Blood Count ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Healthy Population ◽  
Corpuscular Hemoglobin ◽  
Significant Difference

Introduction: numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy. The aim of this study is to look for the reference values for healthy pregnant women of the Northwest region of Morocco, to compare them to those of non-pregnant women (control) and to those of the literature. Methods: blood samples were taken voluntarily from 3898 healthy pregnant women from 18 to 46 years old who presented themselves at the center of health Kalaa and at the service of gynecology obstetrics of the Provincial Hospital Center of M'diq (Morocco), for prenatal care. To establish the reference intervals of the CBC for non-pregnant women, a control group was constituted by 7035 healthy women from 18 to 50 years old selected according to the Moroccan law of blood donation. The CBC was measured on a Sysmex KX21N® analyzer. For each sample a systematic blood smear was done to determine the leukocyte differential. Results: a statistically significant difference between the pregnant women and control group was noted (p < 0.05) for all the hematological parameters: red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, basophils, eosinophils, lymphocytes, monocytes, platelets and mean platelet volume. So, the comparison of the averages established between the first, second and third trimester of pregnancy showed the existence of a significant variation with regard to all the parameters of the CBC test looked for (p < 0.001). Conclusion: the present study provides additional baseline data for basic hematological parameters in healthy pregnant Moroccan women and concluded that pregnancy in women has the tendency to alter some hematological indices. For these reasons, there is an interest to take these modifications into account for optimal maternal and fetal medical care.

Interest of the XN-10® Analyzer to Screen for Myelodysplastic Syndromes on Complete Blood Count (CBC) Especially with Hemoglobin Levels and Neut-WX

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5518-5518
Author(s):  
Robin Boutault ◽  
Sebastien Tremblais ◽  
Mathilde De Oliveira Lopes ◽  
Pierre Peterlin ◽  
Yannick Le Bris ◽  
...  
Keyword(s):  
Myelodysplastic Syndromes ◽  
Blood Count ◽  
Complete Blood Count ◽  
Conflicts Of Interest ◽  
Normal Karyotype ◽  
University Hospital ◽  
Multilineage Dysplasia ◽  
End Point ◽  
Group 2 ◽  
A Prospective Study

Abstract A prospective study was performed over one year at Nantes University Hospital in France, in order to investigate whether suspected myelodysplastic syndromes (MDS) could be detected on a complete blood count (CBC), the most rapid laboratory investigation. Indeed, the recently developed XN-10® (Sysmex, Kobe, Japan), provides novel CBC parameters witch could be useful to discriminate such patients from normal samples or from cytopenia of other etiology. Seventy-nine patients were enrolled in the study, for whom a diagnosis of MDS was concluded based on CBC, bone marrow smears examination and karyotype. All patients were free of treatment, including transfusions, at inclusion. They were 40 men and 39 women with a median age of 77,9 years (range 36,4-92,4). CBC were performed on a Sysmex analyzer XN-10®, including investigation of reticulocytes and fluorimetric analysis of platelets. For comparison with normal values, results from 776 healthy samples, for which CBC were performed on the same analyzer and generated no flag, were used. All had parameters within the normal range according to age. The classical parameters of hemoglobin level, Mean Corpuscular Volume (MCV), reticulocytes, platelets and neutrophil counts were recorded. In addition, the extra-parameters, immature reticulocytes fraction (IRF%), platelets by fluorescence (PLT-F) and immature platelets fraction (IPF%), were taken into account. The neutrophils median position on the three axes as well as their dispersion (Neut-WX) were also measured by the analyser. The primary end-point was to discriminate between MDS and healthy patients and the secondary end-point was to distinguish MDS with excess blasts, MDS with multilineage dysplasia and MDS with single lineage dysplasia within the MDS group and by comparison with controls. According to the WHO 2016 classification, 27 patients in the cohort had MDS with excess blasts, 26 MDS with multilineage dysplasia (among whom 7 had ring sideroblasts [RS], group 2), 16 MDS-RS and single lineage dysplasia, 7 MDS with single lineage dysplasia and 3 MDS with isolated del(5q). Forty-four patients had a normal karyotype and 28 displayed anomalies classically reported in MDS, including 5 complex karyotypes. Among the latter, 4 were associated with MDS with excess blasts. Both classical and extra parameters indeed showed significant differences between the subgroups tested. Among the whole group of MDS patients, a number of parameters of all lineages were statistically different from the healthy cohort. The median level of hemoglobin was 9,8 g/dL (range 4,7-14,9), (p<0,0001), the median MCV 104,3 fL (range 75,4-123,9; p<0,0001), reticulocyte counts 44,3x109/L (range 8-165,9; p=0,041) and IRF% 16,7% (range 2,4-50,9; p<0,0001). An hemoglobin value below 11,5 g/dL was strongly suggestive of MDS with a sensitivity of 81% and specificity of 100%. The median platelet count was 164x109/L (range 8-505; p<0,0001) and median IPF% 8,8% (1,2-42; p<0,0001). Among leukocyte parameters, the MDS median neutrophil count was significantly lower at 2,15x109/L (range 0,17-13,67; p<0,001) and the Neut-WX value increased above 350. The latter, by itself, allowed to make a diagnosis of MDS with a sensitivity of 73,1% and a specificity of 96,9%. When considering the three MDS subgroups of MDS with excess blasts, multilineage or single lineage dysplasia, although each of them was significantly different from controls for hemoglobin levels, MCV, IRF% and neutrophil counts (p<0,0001), they could not be discriminated by these parameters. In the subgroup of MDS with single lineage dysplasia, platelet counts were similar to those of controls, yet significantly higher than for MDS with excess blast or with multilineage dysplasia (p=0,004 and p=0,029 respectively). Taken together, this study demonstrates that a simple CBC allows to screen for MDS using thresholds of 11,5 g/dL for hemoglobin and of 350 for Neut-WX. Blood smear examination should be performed in this situation even if the XN-10® analyzer does not raise an alarm, especially in unknown older patients. Disclosures No relevant conflicts of interest to declare.

scholarly journals Vaginal Colonization by Escherichia coli in Pregnant Women at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

2017 ◽  
Vol 24 (3) ◽  
pp. 39-49
Author(s):  
Taghreed J. Jamal ◽  
Hassan El-Banna A. Younus ◽  
Hassan S. Abduljabbar ◽  
Asif A. Jiman-Fatani ◽  
Amal F. Makled
Keyword(s):  
Escherichia Coli ◽  
Saudi Arabia ◽  
Pregnant Women ◽  
Antimicrobial Agents ◽  
University Hospital ◽  
Vaginal Colonization ◽  
Antimicrobial Susceptibility Tests ◽  
Automated Technology ◽  
King Abdulaziz University ◽  
Susceptibility Tests

Maternal and neonatal infections by Escherichia coli remain a challenging problem for obstetricians and pediatricians. This study aims to determine the prevalence of vaginal colonization by Escherichia coli among pregnant women attending the Antenatal Clinics at King Abdulaziz University Hospital in Jeddah- Saudi Arabia, and to investigate the susceptibility of isolated Escherichia coli to the most commonly used antimicrobials. In this study, 100 pregnant women in the last trimester and 25 non-pregnant women were screened for vaginal colonization of Escherichia coli. The suspected colonies were identified by conventional methods and were confirmed by automated technology "Vitek 2 System". Also, antimicrobial susceptibility tests were done by the same methods". Escherichia coli isolates were serotyped to detect the presence of K1 antigen. Out of 100 pregnant women in the last trimester; twenty-one (21%) were Escherichia coli positive. Also, out of 25 non-pregnant women; four (16%) were Escherichia coli-positive. All of the isolated Escherichia coli were susceptible to most antimicrobial agents. The percentage of vaginal Escherichia coli resistance to trimethoprim/sulfamethoxazole, ampicillin and piperacillin ranged from 38.1% to 42.9%. The virulence factor K1 antigen was demonstrated in 42.9% of Escherichia coli -positive pregnant women.

scholarly journals COVID-19 related complete blood count changes among asymptomatic pregnant women

2021 ◽  
Vol 10 (2) ◽  
Author(s):  
Waleed F Gharib ◽  
Hesham Nasser ◽  
Ahmed M.A. Sobh ◽  
Rasha E Khamees
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Eosinophil Count ◽  
Blood Count ◽  
Complete Blood Count ◽  
Confirmatory Test ◽  
Nasopharyngeal Swab ◽  
Care Clinic ◽  
Entire Study ◽  
Study Population

Objective: To evaluate complete blood count (CBC) changes that suggest coronavirus disease-2019 (COVID-19) among asymptomatic pregnant women attending routine antenatal care Methods: A cross-sectional study included 187 healthy pregnant women who were attending the antenatal care clinic of a tertiary University hospital between March and June 2020. After a thorough history and examinations, a venous blood sample was taken from each participant for complete and differential blood counts. Those who showed CBC findings suggestive of COVID-19 were further scheduled for a nasopharyngeal swab for detection of SARS-CoV-2 specific antigens through polymerase chain reaction (PCR). Results: We found 5.3% (n=10) of the study population showed CBC changes that are suggestive of COVID-19. When they were scheduled for nasopharyngeal swab for a PCR confirmatory test, 30% (n=3) of them were PCR positive (which represented 1.6% of the entire study population). The most frequently encountered COVID-19-suggestive change in peripheral blood leukocyte differential counts was leucopenia (100%), followed by decreased eosinophil count (50%), then neutropenia and lymphocytopenia (30%). Conclusions: Certain differential leucocyte count changes (leucopenia, neutropenia, lymphocytopenia and decreased eosinophil count) among asymptomatic pregnant women might be related to COVID-19 infection and may indicate a need for further testing.

scholarly journals Asymptomatic Bacteriuria in Pregnant Women in Jeddah, Western Region of Saudi Arabia: Call for Assessment

2010 ◽  
Vol 17 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Sharifa A. Al Sibiani
Keyword(s):  
Saudi Arabia ◽  
Pregnant Women ◽  
Asymptomatic Bacteriuria ◽  
Clinic Visit ◽  
University Hospital ◽  
National Scale ◽  
Lack Of Information ◽  
King Abdulaziz University ◽  
Nation Wide Survey ◽  
Low Prevalence

To determine the prevalence and the causative organisms of asymptomatic bacteriuria among pregnant women attending their first prenatal visit at King Abdulaziz University Hospital and in a private clinic at Dr. Erfan and Bagedo Hospital, Jeddah, Saudi Arabia. A retrospective analysis was performed of the routine prenatal screening (urine culture tests) of 9,698 women attending their first prenatal clinic visit between 1 January 2004 to 31 December 2007. They were reviewed, analyzed, and correlated with data on patients’ age, nationality, gravidity, and number of previous abortions. Of 9,698 women, only 166 (1.7%) showed significant bacterial growth, and 1,918 patients (19.8%) were reported as heavy mixed growth. The most common bacterium isolated was Escherichia coli on 88 patients (53%). In this study, low prevalence of bacteriuria among pregnant women was compared to the only two available published studies conducted in the 80's in Saudi Arabia. In view of the lack of information regarding asymptomatic bacteriuria in pregnancy, and the findings of this study, the importance of a conducting a nation-wide survey to guide the revision of practice on a national scale in Saudi Arabia has increased.

INTESTINAL PARASITE INFECTION, CHANGE OF COMPLETE BLOOD COUNT BEFORE AND AFTER TREATMENT, RELATED FACTORS OF PATIENT IN HUE UNIVERSITY HOSPITAL

2017 ◽  
pp. 62-68
Author(s):  
Xuan Tuan Anh Dinh ◽  
Nu Phuong Anh Ton
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Intestinal Parasite ◽  
Clonorchis Sinensis ◽  
Parasite Infection ◽  
Trichuris Trichiura ◽  
University Hospital ◽  
Intestinal Helminth ◽  
Mild Anemia ◽  
Parasite Infections

Introduction: Intestinal parasite infections still are very common in Vietnam and have special cause serious consequences for human health. Mastery on the prevalence of them should be done. Materials and methods: A cross session with monitoring study were carried out to use the wet mount direct examination, Kato technique and the complete blood count for evaluation the rate of intestinal parasite infections in 590 patients attending to the Parasitology Department in Hue University Hospital. We also interviewed them to reveal their life’s hygienic condition, knowledge and risk behaviour of intestinal parasite infections. Result: The rate of soil transmitted intestinal helminth was 14.1%. Primarily, patients were infected: hookworm (8.5%), Trichiuris trichiura (4.3%) and then Clonorchis sinensis 0.9%. Being 100% of patients infected with Clonorchis sinensis had eosinophile increased and decreased significantly after 1 month of treatment response. Being 53% of patients infected with hookworm and/or Trichuris trichiura had eosinophils increased, and decrease to the normal after 1 month of treatment response. Only patients, who were infected with hookworm and/or Trichiuris trichiura, had a mild anemia, the rate of cases had mild anemia: hookworm 18.8%, Trichuris trichiura 13.3%. The rate of risk behavior of intesstinal parasite infection were: no hand washing before eating and after defecation, unregular anthelmintic treatment, eating raw beef, pork, and fish. Conclusion: Intestinal parasite infections in patients attending to the Hue University Hospital were mainly hookworm, Trichuris trichiura and Clonorchis sinensis. Increasing the eosinophils or decreasing the hemoglobin values or mild anemia is the signs of intestinal parasitic diseases. To prevention of intestinal helminth infection, it should be eating well cooking dishes, washing hands totally and regular anthelmintic treatment. Key words: Nematodes, trematodes, eosinophilia, anemia

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