scholarly journals Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10122
Author(s):  
Sahra Pajenda ◽  
Andreja Figurek ◽  
Ludwig Wagner ◽  
Daniela Gerges ◽  
Alice Schmidt ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Plasma Levels ◽  
Binding Protein ◽  
Kidney Injury ◽  
Fluid Loss ◽  
Interstitial Tissue ◽  
High Morbidity ◽  
Heparin Binding ◽  
Granzyme A ◽  
Heparin Binding Protein

Background Sepsis-related acute kidney injury (AKI) is associated with high morbidity and mortality among patients. Underlying pathomechanisms include capillary leakage and fluid loss into the interstitial tissue and constant exposure to pathogens results in activation of inflammatory cascades, organ dysfunction and subsequently organ damage. Methods To identify novel factors that trigger sepsis-related acute kidney injury, plasma levels of Granzyme A, as representative of a lymphocyte-derived protease, and heparin-binding protein as indicator for neutrophil-derived mediators, were investigated retrospectively in 60 sepsis patients. Results While no association was found between plasma levels of lymphocyte-derived Granzyme A and the incidence of sepsis-related AKI, sepsis patients with AKI had significantly higher plasma levels of heparin-binding protein compared to those without AKI. This applies both to heparin-binding protein peak values (43.30 ±  23.34 vs. 30.25 ±  15.63 pg/mL; p = 0.005) as well as mean values (27.93 ±  14.39 vs. 22.02 ±  7.65 pg/mL; p = 0.021). Furthermore, a heparin-binding protein cut-off value of 23.89 pg/mL was established for AKI diagnosis. Conclusion This study identifies the neutrophil-derived heparin-binding protein as a valuable new biomarker for AKI in sepsis. Beyond the diagnostic perspective, this offers prospect for further research on pathogenesis of AKI and novel therapeutic approaches.

scholarly journals Heparin-binding protein (HBP) improves prediction of sepsis-related acute kidney injury

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jonas Tverring ◽  
◽  
Suvi T. Vaara ◽  
Jane Fisher ◽  
Meri Poukkanen ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Binding Protein ◽  
Kidney Injury ◽  
Heparin Binding ◽  
Heparin Binding Protein

scholarly journals Activation of M1 macrophages in sepsis-induced acute kidney injury in response to heparin-binding protein

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0196423 ◽  
Author(s):  
Li Xing ◽  
Lu Zhongqian ◽  
Song Chunmei ◽  
Chen Pingfa ◽  
He Lei ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Binding Protein ◽  
Kidney Injury ◽  
Heparin Binding ◽  
M1 Macrophages ◽  
Heparin Binding Protein

Heparin-binding protein as a biomarker of acute kidney injury in critical illness

2017 ◽  
Vol 61 (7) ◽  
pp. 797-803 ◽  
Author(s):  
J. Tydén ◽  
H. Herwald ◽  
M. Hultin ◽  
J. Walldén ◽  
J. Johansson
Keyword(s):  
Acute Kidney Injury ◽  
Critical Illness ◽  
Binding Protein ◽  
Kidney Injury ◽  
Heparin Binding ◽  
Heparin Binding Protein

scholarly journals A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Yang Yang ◽  
Guihuan Liu ◽  
Qingnan He ◽  
Jie Shen ◽  
Linyong Xu ◽  
...  
Keyword(s):  
Binding Protein ◽  
Research Progress ◽  
Noncommunicable Diseases ◽  
Acute Bacterial Meningitis ◽  
High Morbidity ◽  
Heparin Binding ◽  
Clinical Prediction ◽  
Heparin Binding Protein ◽  
Detection And Diagnosis ◽  
Effective Diagnosis

Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from polynuclear neutrophils. The biosynthetic HBP in neutrophils is rapidly released under the stimulation of bacteria, resulting in increased vascular permeability and edema. It is reasonable to speculate that the HBP in plasma may serve as a novel diagnostic marker for sepsis, bacterial skin infection, acute bacterial meningitis, leptospirosis, protozoan parasites, and even some noncommunicable diseases. It implies that in the detection and diagnosis of sepsis, it will be possible to make relevant diagnosis through this new indicator in the future. In this review, we summarize the typical biological function of HBP and its latest research progress to provide theoretical basis for clinical prediction and diagnosis of sepsis.

scholarly journals Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock

Critical Care ◽  
2012 ◽  
Vol 16 (3) ◽  
pp. R90 ◽  
Author(s):  
Adam Linder ◽  
Per Åkesson ◽  
Malin Inghammar ◽  
Carl-Johan Treutiger ◽  
Anna Linnér ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Intensive Care ◽  
Plasma Levels ◽  
Binding Protein ◽  
Heparin Binding ◽  
Elevated Plasma ◽  
Heparin Binding Protein ◽  
Sepsis And Septic Shock

Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study

2011 ◽  
Vol 61 (4) ◽  
pp. 375-379 ◽  
Author(s):  
Michelle S. Chew ◽  
Adam Linder ◽  
Stefan Santen ◽  
Anders Ersson ◽  
Heiko Herwald ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Plasma Levels ◽  
Prospective Cohort ◽  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein

scholarly journals TNFR1, TNFR2, neutrophil gelatinase-associated lipocalin and heparin binding protein in identifying sepsis and predicting outcome in an intensive care cohort

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maria Bergquist ◽  
Line Samuelsson ◽  
Anders Larsson ◽  
Jonas Tydén ◽  
Joakim Johansson ◽  
...  
Keyword(s):  
Binding Protein ◽  
Tumor Necrosis Factor Receptor ◽  
Kidney Injury ◽  
Heparin Binding ◽  
Logistic Regression Models ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Heparin Binding Protein ◽  
Predicting Outcome ◽  
Neutrophil Gelatinase ◽  
Necrosis Factor

Abstract To date no biomarkers can aid diagnosing sepsis with adequate accuracy. We set out to assess the ability of Tumor necrosis factor receptor (TNFR) 1 and 2, Neutrophil gelatinase-associated lipocalin (NGAL) and Heparin binding protein (HBP) to discriminate sepsis from non-infected critically ill patients in a large ICU cohort, and to evaluate their value to predict mortality at 30 days. Adult patients admitted to the ICU with an arterial catheter were included. Clinical data and blood samples were prospectively recorded daily. Diagnoses were set retrospectively. Descriptive statistics and logistic regression models were used. NGAL, TNFR1 and TNFR2 were higher in sepsis patients compared to other diagnoses, as well as in non-survivors compared to survivors. In addition, these biomarkers increased with increasing stages of acute kidney injury. TNFR1 and TNFR2 performed similarly to NGAL and CRP in identifying sepsis patients, but they performed better than CRP in predicting 30-day mortality in this ICU cohort. Thus, TNFR1 and TNFR2 may be particularly useful in identifying high risk sepsis patients and facilitate relevant health care actions in this group of sepsis patients.

scholarly journals Heparin-binding protein is significantly increased in acute pancreatitis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Martina Sjöbeck ◽  
Hanna Sternby ◽  
Heiko Herwald ◽  
Henrik Thorlacius ◽  
Sara Regnér
Keyword(s):  
Acute Pancreatitis ◽  
Disease Severity ◽  
Fluid Balance ◽  
Binding Protein ◽  
Pearson Correlation ◽  
University Hospital ◽  
High Morbidity ◽  
Heparin Binding ◽  
Significant Group ◽  
Heparin Binding Protein

Abstract Background Most patients with acute pancreatitis (AP) experience mild, self-limiting disease with little or no need for hospital care. However, 20–25% of patients develop a more severe and potentially life-threatening condition with progressive systemic inflammatory response syndrome (SIRS) and multiorgan failure, resulting in high morbidity and mortality rates. Predicting disease severity at an early stage is important, as immediate supportive care has been demonstrated to reduce the incidence of SIRS and organ failure, improving patient outcome. Several studies have demonstrated elevated levels of heparin-binding protein (HBP) in patients with sepsis and septic shock, and HBP is believed to play a part in endothelial dysfunction leading to vascular leakage. As HBP levels increase prior to other known biomarkers, HBP has emerged as a promising early predictor of severe sepsis with organ dysfunction. Methods Patients admitted to Skåne University Hospital in Malmö between 2010 and 2013 fulfilling the criteria for AP were identified in the emergency department and prospectively enrolled in this study. The primary outcome was measured levels of HBP upon hospital admission in patients with confirmed AP. Correlations among HBP concentrations, disease severity and fluid balance were considered secondary endpoints. The correlation between HBP levels and fluid balance were analysed using Pearson correlation, and the ability of HBP to predict moderately severe/severe AP was assessed using a receiver operating characteristic (ROC) curve. Results The overall median HBP level in this study was 529 (307–898) ng/ml. There were no significant group differences in HBP levels based on AP severity. Fluid balance differed significantly between patients with mild versus moderately severe and severe pancreatitis, but we found no correlation between HBP concentration and fluid balance. Conclusions HBP levels are dramatically increased in patients with AP, and these levels far exceed those previously reported in other conditions. In this study, we did not observe any significant correlation between HBP levels and disease severity or the need for intravenous fluid. Additional studies on HBP are needed to further explore the role of HBP in the pathogenesis of AP and its possible clinical implications.

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