scholarly journals Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome

Critical Care ◽  
2013 ◽  
Vol 17 (4) ◽  
pp. R155 ◽  
Author(s):  
Qionghua Lin ◽  
Jie Shen ◽  
Lihua Shen ◽  
Zhongwei Zhang ◽  
Fengming Fu
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Plasma Levels ◽  
Distress Syndrome ◽  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein

scholarly journals Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome

2021 ◽  
Vol 17 (11) ◽  
pp. e1010114
Author(s):  
Hendrik Possemiers ◽  
Thao-Thy Pham ◽  
Marion Coens ◽  
Emilie Pollenus ◽  
Sofie Knoops ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Early Stage ◽  
Binding Protein ◽  
Parasite Load ◽  
Lung Pathology ◽  
Lethal Complications ◽  
Continuous Presence

Malaria is a hazardous disease caused by Plasmodium parasites and often results in lethal complications, including malaria-associated acute respiratory distress syndrome (MA-ARDS). Parasite sequestration in the microvasculature is often observed, but its role in malaria pathogenesis and complications is still incompletely understood. We used skeleton binding protein-1 (SBP-1) KO parasites to study the role of sequestration in experimental MA-ARDS. The sequestration-deficiency of these SBP-1 KO parasites was confirmed with bioluminescence imaging and by measuring parasite accumulation in the lungs with RT-qPCR. The SBP-1 KO parasites induced similar lung pathology in the early stage of experimental MA-ARDS compared to wildtype (WT) parasites. Strikingly, the lung pathology resolved subsequently in more than 60% of the SBP-1 KO infected mice, resulting in prolonged survival despite the continuous presence of the parasite. This spontaneous disease resolution was associated with decreased inflammatory cytokine expression measured by RT-qPCR and lower expression of cytotoxic markers in pathogenic CD8+ T cells in the lungs of SBP-1 KO infected mice. These data suggest that SBP-1-mediated parasite sequestration and subsequent high parasite load are not essential for the development of experimental MA-ARDS but inhibit the resolution of the disease.

scholarly journals High Levels of Soluble Triggering Receptor Expressed on Myeloid Cells–Like Transcript (TLT)-1 Are Associated With Acute Respiratory Distress Syndrome

2018 ◽  
Vol 24 (7) ◽  
pp. 1122-1127 ◽  
Author(s):  
Jessica Morales-Ortíz ◽  
Matthew T. Rondina ◽  
Samuel M. Brown ◽  
Colin Grissom ◽  
A. Valance Washington
Keyword(s):  
Septic Shock ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Plasma Levels ◽  
Distress Syndrome ◽  
White Blood Cells ◽  
Myeloid Cells ◽  
Control Group ◽  
Healthy Controls

We have previously demonstrated that elevated levels of soluble triggering receptor expressed on myeloid cells–like transcript 1 (sTLT-1) modulate sepsis-induced inflammation and positively correlate with disseminated intravascular coagulation (DIC). Here, we evaluate the clinical implications of plasma sTLT-1 in acute respiratory distress syndrome (ARDS), which is common in sepsis patients. Soluble TLT-1 levels in the plasma of ARDS patients (n = 20) were determined by slot blot analysis and were compared with clinical parameters to identify significant associations. For comparisons to ARDS, we also measured sTLT-1 levels in matched healthy controls (n = 20). Of the 20 plasma samples evaluated from patients with ARDS, 60% were diagnosed with sepsis and 40% were diagnosed with septic shock. The white blood cells (WBCs) of patients with ARDS were found to be significantly elevated over healthy controls with a mean of 13 k/µL over 6.2 k/µL, respectively. The mean plasma levels of sTLT-1 were 148.4 pg/mL ± 16.52 in the patient cohort and 92.45 pg/mL ± 17.12 in the control group ( P = .02). No statistically significant correlations were found between plasma levels of sTLT-1 and WBCs, sepsis, septic shock or acute physiologic, and chronic health evaluation II scores. A statistically significant inverse correlation (r2 = .25, P < .05) was found between plasma sTLT-1 and peripheral platelet counts in patients with ARDS. Increased levels of sTLT-1 in ARDS patients suggest that TLT-1 may mediate the pathobiology of ARDS. Moreover, our data are the first to demonstrate a specific platelet marker in the development of ARDS due to sepsis.

scholarly journals A longitudinal change of syndecan-1 predicts risk of acute respiratory distress syndrome and cumulative fluid balance in patients with septic shock: a preliminary study

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Yuka Kajita ◽  
Tsuguaki Terashima ◽  
Hisatake Mori ◽  
Md. Monirul Islam ◽  
Takayuki Irahara ◽  
...  
Keyword(s):  
Septic Shock ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Fluid Balance ◽  
Plasma Levels ◽  
Distress Syndrome ◽  
Organ Damage ◽  
Apache Ii Score ◽  
Cumulative Fluid Balance

Abstract Background The purpose of this study is to investigate the time course of syndecan-1 (Syn-1) plasma levels, the correlation between Syn-1 and organ damage development, and the associations of Syn-1 level with cumulative fluid balance and ventilator-free days (VFD) in patients with septic shock. Methods We collected blood samples from 38 patients with septic shock upon their admission to ICU and for the first 7 days of their stay. Syn-1 plasma level, acute respiratory distress syndrome (ARDS), other organ damage, VFD, and cumulative fluid balance were assessed daily. Results Over the course of 7 days, Syn-1 plasma levels increased significantly more in patients with ARDS than in those without ARDS. Patients with high levels of Syn-1 in the 72 h after ICU admission had significantly higher cumulative fluid balance, lower PaO2/FiO2, and fewer VFD than patients with low levels of Syn-1. Syn-1 levels did not correlate with sequential organ failure assessment score or with APACHE II score. Conclusions In our cohort of patients with septic shock, higher circulating level of Syn-1 of cardinal glycocalyx component is associated with more ARDS, cumulative positive fluid balance, and fewer VFD. Measurement of Syn-1 levels in patients with septic shock might be useful for predicting patients at high risk of ARDS.

scholarly journals IGF1 and IGFBP3 in acute respiratory distress syndrome

2012 ◽  
Vol 166 (1) ◽  
pp. 121-129 ◽  
Author(s):  
Amy M Ahasic ◽  
Rihong Zhai ◽  
Li Su ◽  
Yang Zhao ◽  
Konstantinos N Aronis ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Binding Protein ◽  
Severity Of Illness ◽  
Patients At Risk ◽  
Igf Binding ◽  
Fibrotic Lung Diseases ◽  
Circulating Levels

ObjectiveIGF1 and its most abundant binding protein, IGF-binding protein 3 (IGFBP3), have been implicated in fibrotic lung diseases and persistent acute respiratory distress syndrome (ARDS) due to profibrogenic and antiapoptotic activity. Whether circulating levels of IGF1 and IGFBP3 are altered in ARDS and whether they predict progression of and survival from ARDS remains unknown. This study aims to characterize the circulating levels of IGF1 and IGFBP3 in patients at risk for ARDS in relation to i) development of ARDS and ii) mortality among ARDS cases.DesignIn this case–cohort study, consecutive patients with risk factors for ARDS admitted to the intensive care unit were enrolled and followed prospectively for the development of ARDS. Cases were followed for all-cause mortality through day 60. Of the 2397 patients enrolled in the parent study, plasma samples were available in 531 (22%) patients (356 controls and 175 cases) from early in presentation. Total plasma IGF1 and IGFBP3 levels were measured.ResultsAfter adjusting for relevant clinical covariates including severity of illness, IGF1 and IGFBP3 levels were significantly lower in ARDS cases than in controls (odds ratio (OR), 0.58;P=0.006; OR, 0.57;P=0.0015 respectively). Among the ARDS cases, IGF1 and IGFBP3 levels were significantly lower in the 78 (45%) non-survivors (hazard ratio (HR), 0.70;P=0.024; HR, 0.69;P=0.021 respectively).ConclusionsLower circulating levels of IGF1 and IGFBP3 were independently associated with ARDS case status. Furthermore, lower levels were associated with mortality among the ARDS cases. These data support the role of the IGF pathway in ARDS.

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