Heparin-binding protein as a biomarker of acute kidney injury in critical illness

2017 ◽  
Vol 61 (7) ◽  
pp. 797-803 ◽  
Author(s):  
J. Tydén ◽  
H. Herwald ◽  
M. Hultin ◽  
J. Walldén ◽  
J. Johansson
Keyword(s):  
Acute Kidney Injury ◽  
Critical Illness ◽  
Binding Protein ◽  
Kidney Injury ◽  
Heparin Binding ◽  
Heparin Binding Protein

scholarly journals Heparin-binding protein (HBP) improves prediction of sepsis-related acute kidney injury

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jonas Tverring ◽  
◽  
Suvi T. Vaara ◽  
Jane Fisher ◽  
Meri Poukkanen ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Binding Protein ◽  
Kidney Injury ◽  
Heparin Binding ◽  
Heparin Binding Protein

scholarly journals Activation of M1 macrophages in sepsis-induced acute kidney injury in response to heparin-binding protein

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0196423 ◽  
Author(s):  
Li Xing ◽  
Lu Zhongqian ◽  
Song Chunmei ◽  
Chen Pingfa ◽  
He Lei ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Binding Protein ◽  
Kidney Injury ◽  
Heparin Binding ◽  
M1 Macrophages ◽  
Heparin Binding Protein

scholarly journals Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10122
Author(s):  
Sahra Pajenda ◽  
Andreja Figurek ◽  
Ludwig Wagner ◽  
Daniela Gerges ◽  
Alice Schmidt ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Plasma Levels ◽  
Binding Protein ◽  
Kidney Injury ◽  
Fluid Loss ◽  
Interstitial Tissue ◽  
High Morbidity ◽  
Heparin Binding ◽  
Granzyme A ◽  
Heparin Binding Protein

Background Sepsis-related acute kidney injury (AKI) is associated with high morbidity and mortality among patients. Underlying pathomechanisms include capillary leakage and fluid loss into the interstitial tissue and constant exposure to pathogens results in activation of inflammatory cascades, organ dysfunction and subsequently organ damage. Methods To identify novel factors that trigger sepsis-related acute kidney injury, plasma levels of Granzyme A, as representative of a lymphocyte-derived protease, and heparin-binding protein as indicator for neutrophil-derived mediators, were investigated retrospectively in 60 sepsis patients. Results While no association was found between plasma levels of lymphocyte-derived Granzyme A and the incidence of sepsis-related AKI, sepsis patients with AKI had significantly higher plasma levels of heparin-binding protein compared to those without AKI. This applies both to heparin-binding protein peak values (43.30 ±  23.34 vs. 30.25 ±  15.63 pg/mL; p = 0.005) as well as mean values (27.93 ±  14.39 vs. 22.02 ±  7.65 pg/mL; p = 0.021). Furthermore, a heparin-binding protein cut-off value of 23.89 pg/mL was established for AKI diagnosis. Conclusion This study identifies the neutrophil-derived heparin-binding protein as a valuable new biomarker for AKI in sepsis. Beyond the diagnostic perspective, this offers prospect for further research on pathogenesis of AKI and novel therapeutic approaches.

scholarly journals Heparin-binding protein: An early indicator of critical illness and predictor of outcome in cardiac arrest

Resuscitation ◽  
2013 ◽  
Vol 84 (7) ◽  
pp. 935-939 ◽  
Author(s):  
Josef Dankiewicz ◽  
Adam Linder ◽  
Martin Annborn ◽  
Malin Rundgren ◽  
Hans Friberg
Keyword(s):  
Cardiac Arrest ◽  
Critical Illness ◽  
Binding Protein ◽  
Heparin Binding ◽  
Early Indicator ◽  
Heparin Binding Protein

scholarly journals TNFR1, TNFR2, neutrophil gelatinase-associated lipocalin and heparin binding protein in identifying sepsis and predicting outcome in an intensive care cohort

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maria Bergquist ◽  
Line Samuelsson ◽  
Anders Larsson ◽  
Jonas Tydén ◽  
Joakim Johansson ◽  
...  
Keyword(s):  
Binding Protein ◽  
Tumor Necrosis Factor Receptor ◽  
Kidney Injury ◽  
Heparin Binding ◽  
Logistic Regression Models ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Heparin Binding Protein ◽  
Predicting Outcome ◽  
Neutrophil Gelatinase ◽  
Necrosis Factor

Abstract To date no biomarkers can aid diagnosing sepsis with adequate accuracy. We set out to assess the ability of Tumor necrosis factor receptor (TNFR) 1 and 2, Neutrophil gelatinase-associated lipocalin (NGAL) and Heparin binding protein (HBP) to discriminate sepsis from non-infected critically ill patients in a large ICU cohort, and to evaluate their value to predict mortality at 30 days. Adult patients admitted to the ICU with an arterial catheter were included. Clinical data and blood samples were prospectively recorded daily. Diagnoses were set retrospectively. Descriptive statistics and logistic regression models were used. NGAL, TNFR1 and TNFR2 were higher in sepsis patients compared to other diagnoses, as well as in non-survivors compared to survivors. In addition, these biomarkers increased with increasing stages of acute kidney injury. TNFR1 and TNFR2 performed similarly to NGAL and CRP in identifying sepsis patients, but they performed better than CRP in predicting 30-day mortality in this ICU cohort. Thus, TNFR1 and TNFR2 may be particularly useful in identifying high risk sepsis patients and facilitate relevant health care actions in this group of sepsis patients.

The Clinical Utility and Assessment of Renal Biomarkers in Acute Kidney Injury After Abdominal Endovascular Aneurysm Repair. A Systematic Review

2020 ◽  
Vol 25 (44) ◽  
pp. 4695-4701 ◽  
Author(s):  
Georgios Karaolanis ◽  
Zachary F. Williams ◽  
Chris Bakoyiannis ◽  
Dimitrios Hadjis ◽  
Mitchell W. Cox ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Kidney Injury ◽  
Systematic Reviews ◽  
Clinical Utility ◽  
Binding Protein ◽  
Endovascular Aneurysm Repair ◽  
Kidney Injury ◽  
Aortic Aneurysms ◽  
Renal Biomarkers ◽  
Aneurysm Repair

: The widespread adoption of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA) is due to the obvious advantages of the procedure compared to the traditional open repair. However, these advantages have to be weighed against the increased risk of renal dysfunction with EVAR. The evaluation of the perioperative renal function after EVAR has been hampered by the lack of sensitive and specific biochemical markers of acute kidney injury (AKI). The purpose of this study was to summarize all novel renal biomarkers and to evaluate their clinical utility for the assessment of the kidney function after EVAR. A systematic review of the current literature, as the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines, was performed to identify relevant studies with novel renal biomarkers and EVAR. Pubmed and Scopus databases were systemically searched. Studies reporting on thoracic endovascular aortic repair (TEVAR), case reports, case series, letters to the editor, and systematic reviews were excluded. Neutrophil-Gelatinase-Associated Lipocalin, Cystatin C, Liver-type fatty-acid-binding protein were the most common among the eligible studies while Interleukin-18, Retinol binding protein, N-acetyle-b-D-glucosaminidase and microalbumin have a sparse appearance in the literature. These biomarkers have been assessed in plasma as well as urine samples with each sample material having its own advantages and drawbacks. Which of these biomarkers has the most potential for assessing postoperative renal failure after EVAR, remains to be proved. The few studies presented in the literature show the potential clinical utility of these biomarkers, but larger studies with longer follow-up are required to determine the precise relationship between these biomarkers and postoperative acute kidney injury.

The heparin-binding protein interactome in pancreatic diseases

Pancreatology ◽  
2013 ◽  
Vol 13 (6) ◽  
pp. 598-604 ◽  
Author(s):  
Q.M. Nunes ◽  
V. Mournetas ◽  
B. Lane ◽  
R. Sutton ◽  
D.G. Fernig ◽  
...  
Keyword(s):  
Binding Protein ◽  
Heparin Binding ◽  
Pancreatic Diseases ◽  
Heparin Binding Protein ◽  
Protein Interactome
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