scholarly journals CDK inhibitors for muscle stem cell differentiation and self-renewal

2017 ◽  
Vol 6 (2) ◽  
pp. 65-74 ◽  
Author(s):  
Amrudha Mohan ◽  
Atsushi Asakura
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Cdk Inhibitors ◽  
Self Renewal ◽  
Muscle Stem Cell

scholarly journals PDH‐mediated metabolic flow is critical for skeletal muscle stem cell differentiation and myotube formation during regeneration in mice

2019 ◽  
Vol 33 (7) ◽  
pp. 8094-8109 ◽  
Author(s):  
Shimpei Hori ◽  
Yosuke Hiramuki ◽  
Daigo Nishimura ◽  
Fuminori Sato ◽  
Atsuko Sehara-Fujisawa
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Muscle Stem Cell ◽  
Myotube Formation

scholarly journals Regulation of Gene Expression in Neural Stem Cell Differentiation and Self-Renewal

2015 ◽  
Vol 3 (4) ◽  
pp. 87-98
Author(s):  
Mohammad Reza Hashemzadeh ◽  
Zahra Seyedi ◽  
Mohammad Amin Edalatmanesh ◽  
Samaneh Rafiei ◽  
◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Neural Stem Cell ◽  
Regulation Of Gene Expression ◽  
Stem Cell Differentiation ◽  
Self Renewal

scholarly journals Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Augusto Ducati Luchessi ◽  
Sandro Massao Hirabara ◽  
Rafael Herling Lambertucci ◽  
Tavane David Cambiaghi ◽  
Claudio Miguel Costa Neto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Translation Initiation ◽  
Stem Cell Differentiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Muscle Stem Cell ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation

scholarly journals Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes

2017 ◽  
Vol 6 (7) ◽  
pp. 770-779 ◽  
Author(s):  
Tora I. Henriksen ◽  
Peter K. Davidsen ◽  
Maria Pedersen ◽  
Heidi S. Schultz ◽  
Ninna S. Hansen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Muscle Stem Cell

scholarly journals mTORC1 activates PASK-Wdr5 signaling to epigenetically connect the nutrient status with myogenesis

2017 ◽  
Author(s):  
Chintan K. Kikani ◽  
Xiaoying Wu ◽  
Sarah Fogarty ◽  
Seong Anthony Woo Kang ◽  
Noah Dephoure ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Nutrient Status ◽  
Stem Cell Differentiation ◽  
Self Renewal ◽  
Muscle Stem Cell ◽  
Downstream Target ◽  
Cell Functions ◽  
Dietary Nutrients

SummaryIn the tissue microenvironment, stem cell functions are modulated by extrinsic signaling cues such as peptide hormones and dietary nutrients. These signaling cues maintain the balance between self-renewal and differentiation of its resident stem cells. The mechanistic Target of Rapamycin Complex 1 (mTORC1) is implicated to play an important role in regulating this balance, although its downstream effectors in stem cells have been elusive. We have recently shown that the PASK protein kinase phosphorylates Wdr5 to stimulate muscle stem cell differentiation by epigenetically activating the Myogenin promoter. Here, we show that the PASK-Wdr5 signaling pathway is a nutrient-sensitive downstream target of mTORC1 in muscle stem cells. We show that phosphorylation of PASK, and in turn of Wdr5, by mTORC1 is required for the activation of Myogenin transcription, exit from the self-renewal and induction of the myogenesis program. Thus, mTOR connects the diverse extrinsic signaling cues to a central epigenetic process to regulate the muscle stem cell fate between self-renewal and differentiation.

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