scholarly journals PDH‐mediated metabolic flow is critical for skeletal muscle stem cell differentiation and myotube formation during regeneration in mice

2019 ◽  
Vol 33 (7) ◽  
pp. 8094-8109 ◽  
Author(s):  
Shimpei Hori ◽  
Yosuke Hiramuki ◽  
Daigo Nishimura ◽  
Fuminori Sato ◽  
Atsuko Sehara-Fujisawa
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Muscle Stem Cell ◽  
Myotube Formation

scholarly journals Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Augusto Ducati Luchessi ◽  
Sandro Massao Hirabara ◽  
Rafael Herling Lambertucci ◽  
Tavane David Cambiaghi ◽  
Claudio Miguel Costa Neto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Translation Initiation ◽  
Stem Cell Differentiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Muscle Stem Cell ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation

Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation

2009 ◽  
Vol 218 (3) ◽  
pp. 480-489 ◽  
Author(s):  
Augusto D. Luchessi ◽  
Tavane D. Cambiaghi ◽  
Sandro M. Hirabara ◽  
Rafael H. Lambertucci ◽  
Leonardo R. Silveira ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Translation Initiation ◽  
Stem Cell Differentiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Muscle Stem Cell ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation

scholarly journals TRIM32 Regulates Skeletal Muscle Stem Cell Differentiation and Is Necessary for Normal Adult Muscle Regeneration

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30445 ◽  
Author(s):  
Sarah Nicklas ◽  
Anthony Otto ◽  
Xiaoli Wu ◽  
Pamela Miller ◽  
Sandra Stelzer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Muscle Regeneration ◽  
Stem Cell Differentiation ◽  
Normal Adult ◽  
Muscle Stem Cell ◽  
Adult Muscle

scholarly journals Multiscale 3D Genome Reorganization during Skeletal Muscle Stem Cell Lineage Progression and Muscle Aging

2021 ◽  
Author(s):  
Huating WANG ◽  
Yu Zhao ◽  
Yingzhe Ding ◽  
Liangqiang He ◽  
Yuying Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Differentiation ◽  
Regulatory Elements ◽  
Specific Gene ◽  
Muscle Stem Cell ◽  
3D Genome ◽  
Chromatin Looping ◽  
Early Activation

Abstract 3D genome rewiring is known to influence spatiotemporal expression of lineage-specific genes and cell fate transition during stem cell differentiation and aging processes. Yet it is unknown how 3D architecture remodels and orchestrates transcriptional changes during skeletal muscle stem cell (also called satellite cell, SC) activation, proliferation and differentiation course. Here, using in situ Hi-C we comprehensively map the 3D genome topology reorganization at multiscale levels during mouse SC lineage progression and integrate with transcriptional and chromatin signatures to elucidate how 3D genome rewiring dictates gene expression program. Specifically, rewiring at compartment level is most pronounced when SC becomes activated. Striking loss in TAD border insulation and chromatin looping also occurs during early activation process. Meanwhile, TADs can also form TAD clusters and super-enhancer containing TAD clusters orchestrate stage-specific gene expression during SC early activation. Furthermore, we elucidate 3D chromatin regulation of key transcription factor, PAX7 and identify cis-regulatory elements that are crucial for local chromatin architecture and Pax7 expression. Lastly, 3D genome remodeling is profiled in SCs isolated from naturally aging mice, unveiling that geriatric SCs display a prominent gain in long-range contacts and loss of TAD border insulation. Genome compartmentalization and chromatin looping are evidently altered in aged SC while geriatric SC display a more prominent loss in strength of TAD borders. Together, our results implicate 3D chromatin extensively reorganizes at multiple architectural levels and underpin the transcriptome remodeling during SC lineage development and SC aging.

scholarly journals Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes

2017 ◽  
Vol 6 (7) ◽  
pp. 770-779 ◽  
Author(s):  
Tora I. Henriksen ◽  
Peter K. Davidsen ◽  
Maria Pedersen ◽  
Heidi S. Schultz ◽  
Ninna S. Hansen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Muscle Stem Cell

scholarly journals Multiscale 3D Genome Reorganization during Skeletal Muscle Stem Cell Lineage Progression and Muscle Aging

2021 ◽  
Author(s):  
Yu Zhao ◽  
YINGZHE DING ◽  
Liangqiang HE ◽  
Yuying Li ◽  
Xiaona Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Differentiation ◽  
Regulatory Elements ◽  
Specific Gene ◽  
Muscle Stem Cell ◽  
3D Genome ◽  
Chromatin Looping ◽  
Early Activation

3D genome rewiring is known to influence spatiotemporal expression of lineage-specific genes and cell fate transition during stem cell differentiation and aging processes. Yet it is unknown how 3D architecture remodels and orchestrates transcriptional changes during skeletal muscle stem cell (also called satellite cell, SC) activation, proliferation and differentiation course. Here, using in situ Hi-C we comprehensively map the 3D genome topology reorganization at multiscale levels during mouse SC lineage progression and integrate with transcriptional and chromatin signatures to elucidate how 3D genome rewiring dictates gene expression program. Specifically, rewiring at compartment level is most pronounced when SC becomes activated. Striking loss in TAD border insulation and chromatin looping also occurs during early activation process. Meanwhile, TADs can also form TAD clusters and super-enhancer containing TAD clusters orchestrate stage-specific gene expression during SC early activation. Furthermore, we elucidate 3D chromatin regulation of key transcription factor, PAX7 and identify cis-regulatory elements that are crucial for local chromatin architecture and Pax7 expression. Lastly, 3D genome remodeling is profiled in SCs isolated from naturally aging mice, unveiling that geriatric SCs display a prominent gain in long-range contacts and loss of TAD border insulation. Genome compartmentalization and chromatin looping are evidently altered in aged SC while geriatric SC display a more prominent loss in strength of TAD borders. Together, our results implicate 3D chromatin extensively reorganizes at multiple architectural levels and underpin the transcriptome remodeling during SC lineage development and SC aging.

scholarly journals Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster

2018 ◽  
Vol 27 (5) ◽  
pp. 1026-1039.e6 ◽  
Author(s):  
Stas Wüst ◽  
Stefan Dröse ◽  
Juliana Heidler ◽  
Ilka Wittig ◽  
Ina Klockner ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Gene Cluster ◽  
Stem Cell Differentiation ◽  
Muscle Stem Cell

STAT3 induces muscle stem cell differentiation by interaction with myoD

Cytokine ◽  
2009 ◽  
Vol 46 (1) ◽  
pp. 137-141 ◽  
Author(s):  
Yanping Yang ◽  
Ying Xu ◽  
Wei Li ◽  
Guanjun Wang ◽  
Yanqiu Song ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Muscle Stem Cell
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