scholarly journals KDM5B decommissions the H3K4 methylation landscape of self-renewal genes during trophoblast stem cell differentiation

Biology Open ◽  
2018 ◽  
Vol 7 (5) ◽  
pp. bio031245 ◽  
Author(s):  
Jian Xu ◽  
Benjamin L. Kidder
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
H3k4 Methylation ◽  
Self Renewal ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell

scholarly journals Connexin31.1 (Gjb5) Deficiency Blocks Trophoblast Stem Cell Differentiation and Delays Placental Development

2014 ◽  
Vol 23 (21) ◽  
pp. 2649-2660 ◽  
Author(s):  
Mark Kibschull ◽  
Keith Colaco ◽  
Elzbieta Matysiak-Zablocki ◽  
Elke Winterhager ◽  
Stephen J. Lye
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Placental Development ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell

Impact of Galectin-1 on Trophoblast Stem Cell Differentiation and Invasion in In Vitro Implantation Model

2017 ◽  
Vol 25 (5) ◽  
pp. 700-711 ◽  
Author(s):  
Minyue Tang ◽  
Jiali You ◽  
Wei Wang ◽  
Yongchao Lu ◽  
Xiaoling Hu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell ◽  
Implantation Model

scholarly journals A potential role of galectin-1 in promoting mouse trophoblast stem cell differentiation

2018 ◽  
Vol 470 ◽  
pp. 228-239 ◽  
Author(s):  
Jia-Li You ◽  
Wei Wang ◽  
Min-Yue Tang ◽  
Ying-Hui Ye ◽  
Ai-Xia Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Potential Role ◽  
Stem Cell Differentiation ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell

Decreased Lin28 Expression Is Required for Mouse Trophoblast Stem Cell Differentiation.

2010 ◽  
Vol 83 (Suppl_1) ◽  
pp. 451-451
Author(s):  
Quinton A. Winger ◽  
Brittany A. Fromme ◽  
Vanessa A. Enriquez ◽  
Russell V. Anthony ◽  
Gerrit J. Bouma
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell

scholarly journals Transcriptional Repressor Erf Determines Extraembryonic Ectoderm Differentiation

2007 ◽  
Vol 27 (14) ◽  
pp. 5201-5213 ◽  
Author(s):  
Chara Papadaki ◽  
Maria Alexiou ◽  
Grace Cecena ◽  
Mihalis Verykokakis ◽  
Aikaterini Bilitou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transcriptional Repressor ◽  
Stem Cell Differentiation ◽  
Maternal Circulation ◽  
Trophoblast Stem ◽  
Trophoblast Stem Cell ◽  
Ectoplacental Cone

ABSTRACT Extraembryonic ectoderm differentiation and chorioallantoic attachment are fibroblast growth factor (FGF)- and transforming growth factor β-regulated processes that are the first steps in the development of the placenta labyrinth and the establishment of the fetal-maternal circulation in the developing embryo. Only a small number of genes have been demonstrated to be important in trophoblast stem cell differentiation. Erf is a ubiquitously expressed Erk-regulated, ets domain transcriptional repressor expressed throughout embryonic development and adulthood. However, in the developing placenta, after 7.5 days postcoitum (dpc) its expression is restricted to the extraembryonic ectoderm, and its expression is restricted after 9.5 dpc in a subpopulation of labyrinth cells. Homozygous deletion of Erf in mice leads to a block of chorionic cell differentiation before chorioallantoic attachment, resulting in a persisting chorion layer, a persisting ectoplacental cone cavity, failure of chorioallantoic attachment, and absence of labyrinth. These defects result in embryo death by 10.5 dpc. Trophoblast stem cell lines derived from Erf dl1/dl1 knockout blastocysts exhibit delayed differentiation and decreased expression of spongiotrophoblast markers, consistent with the persisting chorion layer, the expanded giant cell layer, and the diminished spongiotrophoblast layer observed in vivo. Our data suggest that attenuation of FGF/Erk signaling and consecutive Erf nuclear localization and function is required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment.

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