An Unusual Cause of a Cystic Lesion with an Osteochondral Defect in the Talus

2011 ◽  
Vol 101 (3) ◽  
pp. 269-274 ◽  
Author(s):  
Evren Fehmi Atay ◽  
Melih Güven ◽  
Murat Çakar ◽  
Cumhur Ibrahim Başsorgun ◽  
Budak Akman ◽  
...  
Keyword(s):  
Osteochondral Defect ◽  
Bone Cyst ◽  
Bone Lesion ◽  
Treatment Method ◽  
Unicameral Bone Cyst ◽  
Bone Lesions ◽  
Osteochondral Graft ◽  
Intraosseous Lipoma ◽  
Benign Bone Lesion ◽  
Rare Lesion

An intraosseous lipoma is a rare benign bone lesion that proliferates from mature lipocytes. It occurs most frequently in the lower limb, particularly in the calcaneus. The talus is an unusual location for this rare lesion. A review of the literature produced only two reports with talar intraosseous lipomas under the name of intraosseous lipomatosis, which described multiple lipomas in different areas. We describe a 38-year-old male patient who had an isolated intraosseous lipoma with an osteochondral defect in the talus and was treated with autologous osteochondral graft transplantation by medial malleolar osteotomy. He could walk with full weightbearing without any assistance at the end of 12 months. Intraosseous lipoma localized in the talus may be confused radiologically with other bone lesions, especially with unicameral bone cyst, if it is associated with an osteochondral defect. Autologous osteochondral graft transplantation is a successful treatment method for talar intraosseous lipoma. (J Am Podiatr Med Assoc 101(3): 269–274, 2011)

scholarly journals A Suspected Pelvic Aneurysmal Bone Cyst in Pregnancy

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Rayan Elkattah ◽  
Brooke Foulk
Keyword(s):  
Clinical Outcomes ◽  
Aneurysmal Bone Cyst ◽  
Bone Fractures ◽  
Bone Cyst ◽  
Bone Lesion ◽  
Pelvic Bone ◽  
Bone Lesions ◽  
Bone Changes ◽  
Challenging Situation ◽  
In Pregnancy

Albeit rare, the majority of identified bone lesions in pregnancy spare the pelvis. Once encountered with a pelvic bone lesion in pregnancy, the obstetrician may face a challenging situation as it is difficult to determine and predict the effects that labor and parturition impart on the pelvic bones. Bone changes and pelvic bone fractures have been well documented during childbirth. The data regarding clinical outcomes and management of pregnancies complicated by pelvic ABCs is scant. Highly suspected to represent an aneurysmal bone cyst, the clinical evaluation of a pelvic lesion in the ilium of a pregnant individual is presented, and modes of delivery in such a scenario are discussed.

scholarly journals Intraosseous lipoma - A rare cause of ‘cystic’ lesion of calcaneum

2016 ◽  
Vol 6 (12) ◽  
pp. 1040-1042
Author(s):  
P Vijayan ◽  
AM Babitha ◽  
LM Ilias ◽  
A Ponniah
Keyword(s):  
Cystic Lesion ◽  
Histopathological Examination ◽  
Multimodality Imaging ◽  
Bone Cyst ◽  
Bone Lesions ◽  
Diagnostic Challenge ◽  
Recurrence Rates ◽  
Intraosseous Lipoma ◽  
Asymptomatic Patients ◽  
Mri Features

Intraosseous lipoma is an uncommon benign bone neoplasm with most of them detected incidentally on multimodality imaging while being evaluated for an unrelated pathology. Long and cancellous bones are commonly involved. This lesion can present a diagnostic challenge to those uninitiated in its appearence because they can be often mistaken for other benign or malignant bone lesions such as enchondroma, fibrous dysplasia, osteoblastoma, bone infarct, bone cyst and chondrosarcoma.   Here we report a case of symptomatic calcaneal lipoma in a 50 year old lady who presented with heel pain. Plain X-ray suggested cystic lesion of calcaneum. MRI revealed the presence of intralesional fat and histopathological examination confirmed the diagnosis. We present this report for its rarity and  the clinching MRI features of this lesion, the excellent prognosis and near negligible recurrence rates, so that misdiagnosis leading to unnecessary workup, biopsy and treatment may be avoided, especially in asymptomatic patients.

scholarly journals Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae Assessed Using Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions

2020 ◽  
Author(s):  
Na Qi ◽  
Qingyuan Meng ◽  
Zhiwen You ◽  
Huiqian Chen ◽  
Yi Shou ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Bone Lesion ◽  
Lumbar Vertebrae ◽  
Standardized Uptake Value ◽  
Lesion Group ◽  
Bone Lesions ◽  
Sample Population ◽  
Quantitative Spect ◽  
Benign Bone Lesion ◽  
Males And Females

Abstract Background: Quantitative bone SPECT/CT is useful for disease follow up and inter-patient comparison. For bone metastatic malignant lesions, spine is the most commonly invaded site. However, Quantitative studies with large samples size investigating all the segments of normal cervical, thoracic and lumbar vertebrae are seldom reported. This study was to evaluate the quantitative tomography of normal vertebrae using 99mTc-MDP with SPECT/CT to investigate the feasibility of standardized uptake value (SUV) for differential diagnosis of benign and malignant bone lesions. Methods: A retrospective study was carried out involving 221 patients (116 males and 105 female) who underwent SPECT/CT scan using 99mTc-MDP. The maximum SUV (SUVmax), mean SUV (SUVmean) and CT values (Hounsfield Unit, HU) of 2416 normal vertebrae bodies, 157 benign bone lesions and 118 malignant bone metastasis foci were obtained. The correlations between SUVmax and CT values, age, height, weight of normal vertebrae were analyzed. Statistical analysis was performed with data of normal, benign and malignant groups corresponding to same sites and gender. Results: The SUVmax and SUVmean of vertebrae in males were markedly higher than those in females (P<0.0009). The SUVmax of each vertebral segment showed a strong negative correlation with CT values in both males and females (r=-0.89 and -0.92, respectively; P<0.0009). The SUVmax of vertebrae also showed significant correlation with weight and height in males (r=0.4, P<0.0009; r=0.28, P=0.005), and significant correlation with weight in females (r=0.32, P=0.009). The SUVmax of normal group, benign bone lesion group and malignant bone metastasis foci group showed statistical differences in both males and females. Conclusion: Our study evaluated SUVmax and SUVmean of normal vertebrae, benign bone lesion and malignant bone metastasis foci with a large sample population. Preliminary results proved the potential value of SUVmax in differentiation benign and malignant bone lesions. The results may provide a quantitative reference for clinical diagnosis and the evaluation of therapeutic response in vertebral lesions.

scholarly journals Standardized uptake values of 99mTc-MDP in normal vertebrae assessed using quantitative SPECT/CT for differentiation diagnosis of benign and malignant bone lesions

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Na Qi ◽  
Qingyuan Meng ◽  
Zhiwen You ◽  
Huiqian Chen ◽  
Yi Shou ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Bone Lesion ◽  
Lesion Group ◽  
Bone Lesions ◽  
Sample Population ◽  
Large Sample Size ◽  
Quantitative Spect ◽  
Large Sample ◽  
Benign Bone Lesion ◽  
Males And Females

Abstract Background Quantitative bone SPECT/CT is useful for disease follow up and inter-patient comparison. For bone metastatic malignant lesions, spine is the most commonly invaded site. However, Quantitative studies with large sample size investigating all the segments of normal cervical, thoracic and lumbar vertebrae are seldom reported. This study was to evaluate the quantitative tomography of normal vertebrae using 99mTc-MDP with SPECT/CT to investigate the feasibility of standardized uptake value (SUV) for differential diagnosis of benign and malignant bone lesions. Methods A retrospective study was carried out involving 221 patients (116 males and 105 females) who underwent SPECT/CT scan using 99mTc-MDP. The maximum SUV (SUVmax), mean SUV (SUVmean) and CT values (Hounsfield Unit, HU) of 2416 normal vertebrae bodies, 157 benign bone lesions and 118 malignant bone metastasis foci were obtained. The correlations between SUVmax of normal vertebrae and CT values of normal vertebrae, age, height, weight, BMI of patients were analyzed. Statistical analysis was performed with data of normal, benign and malignant groups corresponding to same sites and gender. Results The SUVmax and SUVmean of normal vertebrae in males were markedly higher than those in females (P < 0.0009). The SUVmax of each normal vertebral segment showed a strong negative correlation with CT values in both males and females (r = − 0.89 and − 0.92, respectively; P < 0.0009). The SUVmax of normal vertebrae also showed significant correlation with weight, height, and BMI in males (r = 0.4, P < 0.0009; r = 0.28, P = 0.005; r = 0.22, P = 0.026), and significant correlation with weight and BMI in females (r = 0.32, P = 0.009; r = 0.23, P = 0.031). The SUVmax of normal group, benign bone lesion group and malignant bone metastasis foci group showed statistical differences in both males and females. Conclusion Our study evaluated SUVmax and SUVmean of normal vertebrae, benign bone lesion and malignant bone metastasis foci with a large sample population. Preliminary results proved the potential value of SUVmax in differentiation benign and malignant bone lesions. The results may provide a quantitative reference for clinical diagnosis and the evaluation of therapeutic response in vertebral lesions.

scholarly journals Intravoxel incoherent motion diffusion MR and diffusion kurtosis imaging for discriminating atypical bone metastasis from benign bone lesion

2019 ◽  
Vol 92 (1100) ◽  
pp. 20190119 ◽  
Author(s):  
Gang Wu ◽  
Ruyi Xie ◽  
Xuanlin Liu ◽  
Bowen Hou ◽  
Yitong Li ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Benign Lesion ◽  
Intraclass Correlation ◽  
Bone Lesion ◽  
Intravoxel Incoherent Motion ◽  
Diffusion Kurtosis Imaging ◽  
Bone Lesions ◽  
Diffusion Mr ◽  
Benign Bone Lesion ◽  
Diffusion Kurtosis

Objectives: To investigate the feasibility of intravoxel incoherent motion (IVIM) diffusion MR and diffusion kurtosis imaging (DKI) in discriminating atypical bone metastasis from benign bone lesion in patients with tumors. Methods: Patients with bone lesions in lower extremity suspected of metastases were enrolled in this prospective study. IVIM diffusion MR and DKI were performed before biopsy. Apparent diffusion coefficient (ADC), true diffusion (D), perfusion fraction (f) and perfusion-related pseudodiffusion (D*) were generated with IVIM, while mean kurtosis (MK) and mean diffusion (MD) generated with DKI. Two radiologists blinded to pathology results separately measured these parameters for each lesion through drawing region of interest. Intraclass correlation coefficient was used to determine the inter-reader viability in measurement. The patients with pathology-confirmed metastasis or benign lesion were analyzed. The Mann–Whitney test was used to compare IVIM and DKI parameters between metastasis group and benign lesion group. Receiver operating characteristic curves were constructed to evaluate the ability of discrimination. Results: Bone lesions from 28 patients (metastasis, n = 15; benign lesion, n = 13; mean age = 55 years; age range, 34~77) were analyzed with IVIM and DKI. Intraclass correlation coefficient was greater than 0.8 for all parameters. ADC, D and MD were significantly lower in metastases versus benign lesions (p <0.05). MK and f value were significantly higher in metastases versus benign lesions (p<0.05). D* was not significantly different between the two groups (p>0.05). Areas under curve for ADC, D, f, MK and MD were 0.935, 0.939, 0.891, 0.840 and 0.844 respectively. Conclusions: IVIM and DKI derived parameters distinguish between atypical bone metastasis and benign bone lesion in selected patients with tumors. Advances in knowledge: Bone metastasis and benign bone lesion differ in water molecular diffusion. Intravoxel incoherent motion derived true diffusion distinguishes between atypical bone metastasis and benign lesion.

scholarly journals Diagnostic Value of Whole-Body MRI Short Protocols in Bone Lesion Detection in Multiple Myeloma Patients

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1053
Author(s):  
Davide Ippolito ◽  
Teresa Giandola ◽  
Cesare Maino ◽  
Davide Gandola ◽  
Maria Ragusi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow Involvement ◽  
Bone Lesion ◽  
Diagnostic Value ◽  
Lesion Detection ◽  
Lower Limbs ◽  
Whole Body ◽  
Bone Lesions ◽  
Whole Body Mri ◽  
Mri Protocol

The aim of the study is to evaluate the effectiveness of short whole-body magnetic resonance imaging (WBMRI) protocols for the overall assessment of bone marrow involvement in patients with multiple myeloma (MM), in comparison with standard whole-body MRI protocol. Patients with biopsy-proven MM, who underwent a WBMRI with full-body coverage (from vertex to feet) were retrospectively enrolled. WBMRI images were independently evaluated by two expert radiologists, in terms of infiltration patterns (normal, focal, diffuse, and combined), according to location (the whole skeleton was divided into six anatomic districts: skull, spine, sternum and ribs, upper limbs, pelvis and proximal two-thirds of the femur, remaining parts of lower limbs) and lytic lesions number (<5, 5–20, and >20). The majority of patients showed focal and combined infiltration patterns with bone lesions predominantly distributed in the spine and pelvis. As skull and lower limbs are less frequently involved by focal bone lesions, excluding them from the standard MRI protocol allows to obtain a shorter protocol, maintaining a good diagnostic value.

scholarly journals Influence of dosimetry method on bone lesion absorbed dose estimates in PSMA therapy: application to mCRPC patients receiving Lu-177-PSMA-I&T

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Julia Brosch-Lenz ◽  
Carlos Uribe ◽  
Astrid Gosewisch ◽  
Lena Kaiser ◽  
Andrei Todica ◽  
...  
Keyword(s):  
Organs At Risk ◽  
Bone Lesion ◽  
Absorbed Dose ◽  
Hounsfield Unit ◽  
Outcome Data ◽  
Computational Effort ◽  
Bone Lesions ◽  
Castration Resistant Prostate Cancer ◽  
Percentage Difference ◽  
Density Weighting

Abstract Background Patients with metastatic, castration-resistant prostate cancer (mCRPC) present with an increased tumor burden in the skeleton. For these patients, Lutetium-177 (Lu-177) radioligand therapy targeting the prostate-specific membrane antigen (PSMA) has gained increasing interest with promising outcome data. Patient-individualized dosimetry enables improvement of therapy success with the aim of minimizing absorbed dose to organs at risk while maximizing absorbed dose to tumors. Different dosimetric approaches with varying complexity and accuracy exist for this purpose. The Medical Internal Radiation Dose (MIRD) formalism applied to tumors assumes a homogeneous activity distribution in a sphere with unit density for derivation of tumor S values (TSV). Voxel S value (VSV) approaches can account for heterogeneous activities but are simulated for a specific tissue. Full patient-individual Monte Carlo (MC) absorbed dose simulation addresses both, heterogeneous activity and density distributions. Subsequent CT-based density weighting has the potential to overcome the assumption of homogeneous density in the MIRD formalism with TSV and VSV methods, which could be a major limitation for the application in bone metastases with heterogeneous density. The aim of this investigation is a comparison of these methods for bone lesion dosimetry in mCRPC patients receiving Lu-177-PSMA therapy. Results In total, 289 bone lesions in 15 mCRPC patients were analyzed. Percentage difference (PD) of average absorbed dose per lesion compared to MC, averaged over all lesions, was + 14 ± 10% (min: − 21%; max: + 56%) for TSVs. With lesion-individual density weighting using Hounsfield Unit (HU)-to-density conversion on the patient’s CT image, PD was reduced to − 8 ± 1% (min: − 10%; max: − 3%). PD on a voxel level for three-dimensional (3D) voxel-wise dosimetry methods, averaged per lesion, revealed large PDs of + 18 ± 11% (min: − 27%; max: + 58%) for a soft tissue VSV approach compared to MC; after voxel-wise density correction, this was reduced to − 5 ± 1% (min: − 12%; max: − 2%). Conclusion Patient-individual MC absorbed dose simulation is capable to account for heterogeneous densities in bone lesions. Since the computational effort prevents its routine clinical application, TSV or VSV dosimetry approaches are used. This study showed the necessity of lesion-individual density weighting for TSV or VSV in Lu-177-PSMA therapy bone lesion dosimetry.

scholarly journals Recurrence of a Unicameral Bone Cyst in the Femoral Diaphysis

2016 ◽  
Vol 8 (4) ◽  
pp. 484
Author(s):  
Hyun Se Kim ◽  
Kyung Sup Lim ◽  
Sung Wook Seo ◽  
Seung Pil Jang ◽  
Jong Sup Shim
Keyword(s):  
Bone Cyst ◽  
Unicameral Bone Cyst ◽  
Femoral Diaphysis

scholarly journals Fracture of phalanx from simple bone cyst: A rare bone lesion in the hand

2016 ◽  
Vol 5 (2) ◽  
pp. 100
Author(s):  
Emre Inozu ◽  
Ugur Horoz ◽  
Ergin Seven ◽  
Hulda Ozakpinar ◽  
Ali Tellioglu
Keyword(s):  
Bone Cyst ◽  
Bone Lesion ◽  
Simple Bone Cyst
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