scholarly journals Intravoxel incoherent motion diffusion MR and diffusion kurtosis imaging for discriminating atypical bone metastasis from benign bone lesion

2019 ◽  
Vol 92 (1100) ◽  
pp. 20190119 ◽  
Author(s):  
Gang Wu ◽  
Ruyi Xie ◽  
Xuanlin Liu ◽  
Bowen Hou ◽  
Yitong Li ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Benign Lesion ◽  
Intraclass Correlation ◽  
Bone Lesion ◽  
Intravoxel Incoherent Motion ◽  
Diffusion Kurtosis Imaging ◽  
Bone Lesions ◽  
Diffusion Mr ◽  
Benign Bone Lesion ◽  
Diffusion Kurtosis

Objectives: To investigate the feasibility of intravoxel incoherent motion (IVIM) diffusion MR and diffusion kurtosis imaging (DKI) in discriminating atypical bone metastasis from benign bone lesion in patients with tumors. Methods: Patients with bone lesions in lower extremity suspected of metastases were enrolled in this prospective study. IVIM diffusion MR and DKI were performed before biopsy. Apparent diffusion coefficient (ADC), true diffusion (D), perfusion fraction (f) and perfusion-related pseudodiffusion (D*) were generated with IVIM, while mean kurtosis (MK) and mean diffusion (MD) generated with DKI. Two radiologists blinded to pathology results separately measured these parameters for each lesion through drawing region of interest. Intraclass correlation coefficient was used to determine the inter-reader viability in measurement. The patients with pathology-confirmed metastasis or benign lesion were analyzed. The Mann–Whitney test was used to compare IVIM and DKI parameters between metastasis group and benign lesion group. Receiver operating characteristic curves were constructed to evaluate the ability of discrimination. Results: Bone lesions from 28 patients (metastasis, n = 15; benign lesion, n = 13; mean age = 55 years; age range, 34~77) were analyzed with IVIM and DKI. Intraclass correlation coefficient was greater than 0.8 for all parameters. ADC, D and MD were significantly lower in metastases versus benign lesions (p <0.05). MK and f value were significantly higher in metastases versus benign lesions (p<0.05). D* was not significantly different between the two groups (p>0.05). Areas under curve for ADC, D, f, MK and MD were 0.935, 0.939, 0.891, 0.840 and 0.844 respectively. Conclusions: IVIM and DKI derived parameters distinguish between atypical bone metastasis and benign bone lesion in selected patients with tumors. Advances in knowledge: Bone metastasis and benign bone lesion differ in water molecular diffusion. Intravoxel incoherent motion derived true diffusion distinguishes between atypical bone metastasis and benign lesion.

scholarly journals Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae Assessed Using Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions

2020 ◽  
Author(s):  
Na Qi ◽  
Qingyuan Meng ◽  
Zhiwen You ◽  
Huiqian Chen ◽  
Yi Shou ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Bone Lesion ◽  
Lumbar Vertebrae ◽  
Standardized Uptake Value ◽  
Lesion Group ◽  
Bone Lesions ◽  
Sample Population ◽  
Quantitative Spect ◽  
Benign Bone Lesion ◽  
Males And Females

Abstract Background: Quantitative bone SPECT/CT is useful for disease follow up and inter-patient comparison. For bone metastatic malignant lesions, spine is the most commonly invaded site. However, Quantitative studies with large samples size investigating all the segments of normal cervical, thoracic and lumbar vertebrae are seldom reported. This study was to evaluate the quantitative tomography of normal vertebrae using 99mTc-MDP with SPECT/CT to investigate the feasibility of standardized uptake value (SUV) for differential diagnosis of benign and malignant bone lesions. Methods: A retrospective study was carried out involving 221 patients (116 males and 105 female) who underwent SPECT/CT scan using 99mTc-MDP. The maximum SUV (SUVmax), mean SUV (SUVmean) and CT values (Hounsfield Unit, HU) of 2416 normal vertebrae bodies, 157 benign bone lesions and 118 malignant bone metastasis foci were obtained. The correlations between SUVmax and CT values, age, height, weight of normal vertebrae were analyzed. Statistical analysis was performed with data of normal, benign and malignant groups corresponding to same sites and gender. Results: The SUVmax and SUVmean of vertebrae in males were markedly higher than those in females (P<0.0009). The SUVmax of each vertebral segment showed a strong negative correlation with CT values in both males and females (r=-0.89 and -0.92, respectively; P<0.0009). The SUVmax of vertebrae also showed significant correlation with weight and height in males (r=0.4, P<0.0009; r=0.28, P=0.005), and significant correlation with weight in females (r=0.32, P=0.009). The SUVmax of normal group, benign bone lesion group and malignant bone metastasis foci group showed statistical differences in both males and females. Conclusion: Our study evaluated SUVmax and SUVmean of normal vertebrae, benign bone lesion and malignant bone metastasis foci with a large sample population. Preliminary results proved the potential value of SUVmax in differentiation benign and malignant bone lesions. The results may provide a quantitative reference for clinical diagnosis and the evaluation of therapeutic response in vertebral lesions.

scholarly journals Standardized uptake values of 99mTc-MDP in normal vertebrae assessed using quantitative SPECT/CT for differentiation diagnosis of benign and malignant bone lesions

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Na Qi ◽  
Qingyuan Meng ◽  
Zhiwen You ◽  
Huiqian Chen ◽  
Yi Shou ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Bone Lesion ◽  
Lesion Group ◽  
Bone Lesions ◽  
Sample Population ◽  
Large Sample Size ◽  
Quantitative Spect ◽  
Large Sample ◽  
Benign Bone Lesion ◽  
Males And Females

Abstract Background Quantitative bone SPECT/CT is useful for disease follow up and inter-patient comparison. For bone metastatic malignant lesions, spine is the most commonly invaded site. However, Quantitative studies with large sample size investigating all the segments of normal cervical, thoracic and lumbar vertebrae are seldom reported. This study was to evaluate the quantitative tomography of normal vertebrae using 99mTc-MDP with SPECT/CT to investigate the feasibility of standardized uptake value (SUV) for differential diagnosis of benign and malignant bone lesions. Methods A retrospective study was carried out involving 221 patients (116 males and 105 females) who underwent SPECT/CT scan using 99mTc-MDP. The maximum SUV (SUVmax), mean SUV (SUVmean) and CT values (Hounsfield Unit, HU) of 2416 normal vertebrae bodies, 157 benign bone lesions and 118 malignant bone metastasis foci were obtained. The correlations between SUVmax of normal vertebrae and CT values of normal vertebrae, age, height, weight, BMI of patients were analyzed. Statistical analysis was performed with data of normal, benign and malignant groups corresponding to same sites and gender. Results The SUVmax and SUVmean of normal vertebrae in males were markedly higher than those in females (P < 0.0009). The SUVmax of each normal vertebral segment showed a strong negative correlation with CT values in both males and females (r = − 0.89 and − 0.92, respectively; P < 0.0009). The SUVmax of normal vertebrae also showed significant correlation with weight, height, and BMI in males (r = 0.4, P < 0.0009; r = 0.28, P = 0.005; r = 0.22, P = 0.026), and significant correlation with weight and BMI in females (r = 0.32, P = 0.009; r = 0.23, P = 0.031). The SUVmax of normal group, benign bone lesion group and malignant bone metastasis foci group showed statistical differences in both males and females. Conclusion Our study evaluated SUVmax and SUVmean of normal vertebrae, benign bone lesion and malignant bone metastasis foci with a large sample population. Preliminary results proved the potential value of SUVmax in differentiation benign and malignant bone lesions. The results may provide a quantitative reference for clinical diagnosis and the evaluation of therapeutic response in vertebral lesions.

Micro-imaging characterization of mouse models of metastasis

2005 ◽  
Author(s):  
◽  
Christopher Todd Winkelmann
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Mouse Models ◽  
Bone Lesion ◽  
Receptor Expression ◽  
Bone Lesions ◽  
Micro Ct ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide ◽  
Models Of Disease

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Non-invasive imaging techniques have been recently developed to characterize animal models of disease. The overarching hypothesis of this work explores the use of three micro-imaging modalities, including Micro-CT, PET and SPECT, to characterize tumor anatomical progression, metabolism, bone lesion remodeling, and/or gastrin releasing peptide receptor expression in mouse models of metastatic melanoma and prostate and breast cancer bone metastasis. Micro-CT was shown to provide excellent anatomical information about tumor progression in several different tissues including lung, bone, and subcutaneous tissues. Micro-PET imaging demonstrated increased tumor metabolism in melanoma tumors, but was not able to discern bone remodeling in breast cancer bone lesions. Micro-SPECT imaging demonstrated gastrin-releasing peptide receptor expression in a prostate cancer bone metastasis model. The results from this work demonstrate the ability of micro-imaging technologies to non-invasively probe mouse models of disease to obtain information in vivo that is not possible with ex vivo experimental techniques.

Early evaluation of radiation-induced parotid damage with diffusion kurtosis imaging: a preliminary study

2017 ◽  
Vol 59 (2) ◽  
pp. 212-220 ◽  
Author(s):  
Nan Zhou ◽  
Weibo Chen ◽  
Xia Pan ◽  
Jian He ◽  
Jing Yan ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Radiation Dose ◽  
Early Stage ◽  
Intraclass Correlation ◽  
Observer Agreement ◽  
Diffusion Kurtosis Imaging ◽  
Parotid Glands ◽  
Early Evaluation ◽  
Radiation Induced ◽  
Diffusion Kurtosis

Background Radiation-induced parotid gland damage is a common complication of radiotherapy (RT) in patients with nasopharyngeal carcinoma (NPC), which always causes xerostomia, dysphagia, dental caries, and even sleep disorders. Early evaluation of radiation-induced parotid damage is required to facilitate early interventions. Purpose To early-evaluate radiation-induced parotid damage using diffusion kurtosis imaging (DKI) in patients with NPC undergoing RT. Material and Methods Thirty-two patients with NPC underwent DKI for parotid glands pre-RT (two weeks before RT), mid-RT (five weeks after RT began), and post-RT (four weeks after RT). Parotid volume, apparent diffusion coefficient (ADC), corrected diffusion coefficient (D), excess diffusion kurtosis coefficient (K) values, mean radiation dose, and xerostomia degrees were recorded and analyzed. Results During RT, parotid ADC (change rates = 41.3 ± 25.2% at mid-RT, 70.8 ± 34.3% at post-RT) and D (change rates = 41.9 ± 25.2% at mid-RT, 63.2 ± 30.2% at post-RT) increased, while parotid volume (atrophy rates = 31.5 ± 7.9% at mid-RT, 30.6 ± 10.3% at post-RT) and K (change rates = –17.8 ± 11.0% at mid-RT, –29.8 ± 9.0% at post-RT) decreased significantly (all P < 0.001). At post-RT, the change rate of parotid D values was significantly positively correlated with the mean radiation dose ( r = 0.455, P < 0.001). Parotid ADC, D, and K values showed excellent intra- and inter-observer agreement (intraclass correlation coefficient = 0.946-0.985). Conclusion Radiation-induced parotid damage in patients with NPC undergoing RT could be effectively evaluated by DKI in the early stage.

An Unusual Cause of a Cystic Lesion with an Osteochondral Defect in the Talus

2011 ◽  
Vol 101 (3) ◽  
pp. 269-274 ◽  
Author(s):  
Evren Fehmi Atay ◽  
Melih Güven ◽  
Murat Çakar ◽  
Cumhur Ibrahim Başsorgun ◽  
Budak Akman ◽  
...  
Keyword(s):  
Osteochondral Defect ◽  
Bone Cyst ◽  
Bone Lesion ◽  
Treatment Method ◽  
Unicameral Bone Cyst ◽  
Bone Lesions ◽  
Osteochondral Graft ◽  
Intraosseous Lipoma ◽  
Benign Bone Lesion ◽  
Rare Lesion

An intraosseous lipoma is a rare benign bone lesion that proliferates from mature lipocytes. It occurs most frequently in the lower limb, particularly in the calcaneus. The talus is an unusual location for this rare lesion. A review of the literature produced only two reports with talar intraosseous lipomas under the name of intraosseous lipomatosis, which described multiple lipomas in different areas. We describe a 38-year-old male patient who had an isolated intraosseous lipoma with an osteochondral defect in the talus and was treated with autologous osteochondral graft transplantation by medial malleolar osteotomy. He could walk with full weightbearing without any assistance at the end of 12 months. Intraosseous lipoma localized in the talus may be confused radiologically with other bone lesions, especially with unicameral bone cyst, if it is associated with an osteochondral defect. Autologous osteochondral graft transplantation is a successful treatment method for talar intraosseous lipoma. (J Am Podiatr Med Assoc 101(3): 269–274, 2011)

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