scholarly journals The Role of Unknown Risk Factors in Myocardial Infarction

2013 ◽  
Vol 4 (6) ◽  
pp. 430
Author(s):  
Nita A Tanna ◽  
Rakesh Siyaram Srivastava ◽  
Vilpa Arvindbhai Tanna ◽  
Hetal Vithalbhai Vaishnani
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Unknown Risk

MS306 THE ROLE OF UNKNOWN RISK FACTORS IN THE MYOCARDIAL INFARCTION

2010 ◽  
Vol 11 (2) ◽  
pp. 171
Author(s):  
A.A. Rafighdoust ◽  
A.H. Rafighdoust ◽  
M. Haghmoradi ◽  
S. Hoorzad
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Unknown Risk

scholarly journals AB0407 CARDIOVASCULAR BURDEN IN SYSTEMIC SCLEROSIS: QRISK3 VERSUS FRAMINGHAM FOR RISK ESTIMATION

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1232.1-1232
Author(s):  
M. Di Battista ◽  
S. Barsotti ◽  
A. Della Rossa ◽  
M. Mosca
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Systemic Sclerosis ◽  
High Risk ◽  
General Population ◽  
Risk Score ◽  
Predictive Accuracy ◽  
Risk Estimation ◽  
Cross Sectional

Background:Cardiovascular (CV) diseases, namely myocardial infarction and stroke, are not among the most known and frequent complications of systemic sclerosis (SSc), but there is growing evidence that SSc patients have a higher prevalence of CV diseases than the general population [1].Objectives:To compare two algorithms for CV risk estimation in a cohort of patients with SSc, finding any correlation with clinical characteristics of the disease.Methods:SSc patients without previous myocardial infarction or stroke were enrolled. Traditional CV risk factors, SSc-specific characteristics and ongoing therapies were assessed. Framingham and QRISK3 algorithms were then used to estimate the risk of develop a CV disease over the next 10 years.Results:Fifty-six SSc patients were enrolled. Framingham reported a median risk score of 9.6% (IQR 8.5), classifying 24 (42.9%) subjects at high risk, with a two-fold increase of the mean relative risk in comparison to general population. QRISK3 showed a median risk score of 15.8% (IQR 19.4), with 36 (64.3%) patients considered at high-risk. Both algorithms revealed a significant role of some traditional risk factors and a noteworthy potential protective role of endothelin receptor antagonists (p=0.003). QRISK3 was also significantly influenced by some SSc-specific characteristics, as limited cutaneous subset (p=0.01), interstitial lung disease (p=0.04) and non-ischemic heart involvement (p=0.03), with the first two that maintain statistically significance in the multivariate analysis (p=0.02 for both).Conclusion:QRISK3 classifies more SSc patients at high-risk to develop CV diseases than Framingham, and it seems to be influenced by some SSc-specific characteristics. If its predictive accuracy were prospectively verified, the use of QRISK3 as a tool in the early detection of SSc patients at high CV risk should be recommended.References:[1]Ngian GS, Sahhar J, Proudman SM, Stevens W, Wicks IP, Van Doornum S. Prevalence of coronary heart disease and cardiovascular risk factors in a national cross-sectional cohort study of systemic sclerosis. Ann Rheum Dis. 2012;71:1980-3.Disclosure of Interests:None declared

Apolipoprotein E gene polymorphisms in patients with premature myocardial infarction: a case-controlled study in Asian Indians in North India

2003 ◽  
Vol 40 (4) ◽  
pp. 382-387 ◽  
Author(s):  
Prabhat Kumar ◽  
Kalpana Luthra ◽  
Manjari Dwivedi ◽  
Vinay K Behl ◽  
Ravinder M. Pandey ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Gene Polymorphisms ◽  
Asian Indians ◽  
E Gene ◽  
Apo E ◽  
Premature Myocardial Infarction ◽  
E4 Allele ◽  
Conventional Risk Factors

Objectives: Several factors, including abdominal obesity, insulin resistance, diabetes mellitus and low levels of high-density lipoprotein cholesterol have been implicated in the high prevalence and early onset of coronary heart disease in Asian Indians. However, there are no reports regarding the role of apolipoprotein E (apo E) gene polymorphisms in premature myocardial infarction (MI) in this population. This study aimed to study the role of apo E gene polymorphisms in premature MI patients and their relation to serum lipid levels. Design and methods: Apo E gene polymorphisms were analysed in 35 patients with MI aged <40 years and in 45 age- and sex-matched controls using polymerase chain reaction-restriction fragment length polymorphism. Levels of serum lipids were measured in addition to the evaluation of conventional risk factors. Results: Higher frequencies of the apo E4 allele (P<0·0001) and of genotypes E3/E4 (P<0·005) and E4/E4 (P<0·005) were recorded in the premature MI group compared with the controls. Multivariate regression analysis revealed that, after adjusting for other covariates, individuals with the E4 allele were at ~46 times higher odds to develop premature MI compared with individuals without the E4 allele [adjusted odds ratio, OR (95% confidence interval, CI): 45·7 (4·9-421·3)]. Among conventional risk factors, higher risk was observed in those having dyslipidaemia [OR (95% CI): 8·7 (0·9-86·6)] and those with a high waist : hip ratio [OR (95% CI): 5·6 (1·4-21·2)]. Conclusion: Based on the robust association, the apo E4 allele should be considered as an independent risk factor for premature MI in Asian Indians.

scholarly journals The Role of Prediabetes as a Predictive Factor for the Outcomes in Patients with STEMI. Which Is the Right Range of Glycated Hemoglobin to Adopt in This Setting?

2021 ◽  
Vol 11 (12) ◽  
pp. 5518
Author(s):  
Kyriazoula Chatzianagnostou ◽  
Letizia Guiducci ◽  
Umberto Paradossi ◽  
Alberto Ranieri De Caterina ◽  
Annamaria Mazzone ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Risk Factor ◽  
Prognostic Value ◽  
Glycated Hemoglobin ◽  
Who Guidelines ◽  
One Year ◽  
The Right

Background: Prediabetes (preT2D) is considered a subtle adverse cardiovascular (CV) risk factor after acute myocardial infarction. Glycated hemoglobin (HbA1c) ranges to identify preT2D are different between ADA and WHO guidelines (5.7–6.4 vs. 6.0–6.4%, respectively). Aim: To evaluate the prognostic value of HbA1c different preT2D-ranges and their correlation with demographic, instrumental, and laboratory parameters in STEMI. Methods: A total of 1681 patients (mean age 67 ± 13 years; 1217 males) were enrolled. Admission HbA1c was used to identify patients with no-T2D (<5.7%), HbA1c 5.70–5.99%, and WHO-preT2D with HbA1c 6–6.49%, and T2D (HbA1c ≥ 6.5). Results: HbA1c 5.7–5.99, WHO-preT2D, and T2D progressively correlated with an increasing number of CV risk factors. However, only T2D, but not preT2D, was significantly associated with adverse prognosis (in-hospital and one-year death). Conclusions: PreT2D is correlated with CV risk factors, but not with adverse prognosis as compared to no-T2D. Nonetheless, routine HbA1c testing in the STEMI population and HbA1c-5.7–5.99 patient inclusion in the preT2D category may help to identify those who may benefit from intervention and lifestyle strategies to early prevent preT2D progression.

scholarly journals Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4176
Author(s):  
Dorota Drozdz ◽  
Julio Alvarez-Pitti ◽  
Małgorzata Wójcik ◽  
Claudio Borghi ◽  
Rosita Gabbianelli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Preventive Strategies ◽  
Prevention Strategies ◽  
Perinatal Factors ◽  
The Metabolic Syndrome

Obesity has become a major epidemic in the 21st century. It increases the risk of dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk factors and components of the metabolic syndrome. Although overt cardiovascular (CV) diseases such as stroke or myocardial infarction are the domain of adulthood, it is evident that the CV continuum begins very early in life. Recognition of risk factors and early stages of CV damage, at a time when these processes are still reversible, and the development of prevention strategies are major pillars in reducing CV morbidity and mortality in the general population. In this review, we will discuss the role of well-known but also novel risk factors linking obesity and increased CV risk from prenatal age to adulthood, including the role of perinatal factors, diet, nutrigenomics, and nutri-epigenetics, hyperuricemia, dyslipidemia, hypertension, and cardiorespiratory fitness. The importance of ‘tracking’ of these risk factors on adult CV health is highlighted and the economic impact of childhood obesity as well as preventive strategies are discussed.

scholarly journals Pre-infarction angina – a problem more common than one might think. Role of general practitioners according to the 2019 ESC Clinical Practice Guidelines

2020 ◽  
Vol 16 (4) ◽  
pp. 389-395
Author(s):  
Małgorzata Wojciechowska ◽  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Artery Disease ◽  
Test Probability

Background and aims: Some patients present with stenocardial pain long before the onset of myocardial infarction. The aim of the study was to evaluate the mean frequency and duration of typical angina pectoris preceding ST-segment elevation myocardial infarction. In addition, the article addresses the role of general practitioners in the diagnosis of patients with suspected coronary artery disease. Material and methods: The study included a total of 120 patients without prior diagnosis of coronary artery disease who were admitted to the invasive cardiology department with ST-segment elevation myocardial infarction. All patients were assessed to determine symptoms preceding myocardial infarction and risk factors for coronary artery disease. In addition, their pre-test probability of disease was estimated. Results: Out of 120 patients, 43 (35.8%) presented with typical angina symptoms preceding myocardial infarction. The median duration of symptoms was 45 days (min 4, max 2,190 days!), and symptoms recurring for ≥2 weeks were found in 35 patients. The estimated pre-test probability of coronary artery disease was >15% in 40 (93%) patients, and the risk factors for coronary artery disease were prevalent. Conclusions: Typical exertional angina preceding myocardial infarction occurred in over 35% of patients. In some of them, it persisted for a number of months. The estimated probability of coronary artery disease in nearly all patients was >15%. Based on the collected data, the authors conclude that there is a need for broadly understood education so as to improve the understanding of typical anginal symptoms. Correct recognition of symptoms by physicians and patients can significantly reduce the incidence of myocardial infarction and, consequently, bring down the prevalence of heart failure, and decrease mortality rates in patients with coronary artery disease.

scholarly journals Prognostic Role of CMR and Conventional Risk Factors in Myocardial Infarction With Nonobstructed Coronary Arteries

2019 ◽  
Vol 12 (10) ◽  
pp. 1973-1982 ◽  
Author(s):  
Amardeep Ghosh Dastidar ◽  
Anna Baritussio ◽  
Estefania De Garate ◽  
Zsofia Drobni ◽  
Giovanni Biglino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Arteries ◽  
Prognostic Role ◽  
Conventional Risk Factors

scholarly journals Myocardial infarction risk in relation to zinc concentration in toenails

2003 ◽  
Vol 89 (5) ◽  
pp. 673-678 ◽  
Author(s):  
J. M. Martin-Moreno ◽  
L. Gorgojo ◽  
R. A. Riemersma ◽  
J. Gomez-Aracen ◽  
J. D. Kark ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Study Centre ◽  
First Myocardial Infarction ◽  
Control Study

Zn is an essential mineral. The role of Zn in atherosclerosis is not clear. Epidemiological studies, which have reported contradictory results, are limited by the use of serum Zn levels as a marker of intake. We assessed the association of toenail Zn, which integrates dietary Zn intake over 3 to 12 months, with the risk of a first myocardial infarction. Toenail Zn concentrations were determined by neutron activation analysis in the European multi-centre case–control study on antioxidants, myocardial infarction and breast cancer. This multi-centre case–control study included 684 cases and 724 controls from eight European countries and Israel. Toenail Zn levels of controls (adjusted for age and study centre) were positively associated with age, α-tocopherol and Se, but not with additional dietary variables or with classical risk factors for CHD. Average toenail Zn was 106·0 mg/kg in cases (95 % CI 103·1, 108·9) and 107·5 mg/kg in controls (95 % CI 104·5, 110·7). After controlling for cardiovascular risk factors and for centre, the adjusted odds ratios of myocardial infarction for quintiles 2–5 of toenail Zn with respect to the first quintile were 0·97 (95 % CI 0·59, 1·58), 1·15 (95 % CI 0·72, 1·85), 0·91 (95 % CI 0·56, 1·50), and 0·85 (95 % CI 0·52, 1·39). ThePfor trend was 0·45. In conclusion toenail Zn levels (reflecting long-term dietary intake) were not significantly associated with acute myocardial infarction.

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